Global ETD Search

Genome-wide microscopy screening identifies links across processes including a conserved connection between DNA damage control and the microtubule cytoskeleton

Lawson, Jonathan Luke DoneUniversity of Cambridge2015

… high-content microscopy screening of a cell library consisting of over 3000 single mutant strains of the fission yeast, Schizosaccharomyces pombe. Each strain has one nonessential gene knocked-out, allowing investigation of the resulting phenotypes. I report the implementation and …

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Formalist features determining the tempo and mode of evolution in Pseudomonas fluorescens SBW25 : a thesis submitted in partial fulfilment of the requirements for the degree of Ph.D. in Evolutionary Genetics at Massey University, Auckland, New Zealand

Farr, Andrew David2015

massey

Regulation of Tubulin dynamics by the +Tip tracking protein Mal3

des Georges, AmédéeUniversity of Cambridge2008

… network is a central component of the eukaryotic cell cytoskeleton. In the fission yeast S. pombe, a complex of three proteins specifically tracks MT +ends and stabilizes MTs in the cell. It is composed of the proteins Mal3, Tip1 and Tea2. Mal3, the S. pombe homologue of EB1, is a highly conserved …

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Computational methods for multi-omic models of cell metabolism and their importance for theoretical computer science

Angione, ClaudioUniversity of Cambridge2015

… science can help biologists, but also on how biology can inspire computer scientists. On one hand, computer science provides powerful abstraction tools for metabolic networks. Cell metabolism is the set of chemical reactions taking place in a cell, with the aim of maintaining the living state …

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Quantitative genetics of gene expression during fruit fly development

Kölling, NilsUniversity of Cambridge2016

… well as quantitative phenotypes, by exploiting naturally occurring genetic variation in large cohorts of individuals. More recently, the GWAS approach has also been applied to highthroughput RNA sequencing (RNA-seq) data in order to find loci associated with different levels of gene expression, …

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