Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Repressor Proteins"”.
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A synthetic biology platform for malaria parasites based on orthogonal transcriptional control
… parasite Plasmodium falciparum using bacterial repressor proteins. These are the first tools to reliably control malaria parasite transcription and offer the most robust method of conditional gene expression in Plasmodium parasites to date. We develop automated DNA design software to apply this …
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Genome-wide analysis of transcription factors and chromatin in S. cerevisiae
… phenomenon, involving DNA-binding activator and repressor proteins, histones and chromatin factors, histone-modifying enzymes, and the general transcription apparatus. Though many of the genes encoding these factors have been identified in yeast, the role they play in regulating the expression of …
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Functional dissection of ParB homologue and global regulatory protein KorB of RK2
… in RK2 is controlled by cooperativity among four repressors (i.e. KorA, KorB, KorC and TrbA) to tightly regulate replication, stable inheritance and conjugative transfer functions. KorB (358 aa) has dual roles as a global regulator and as an active partitioning protein. This study focuses on its …
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The Role of Cyp33 in MLL Mediated Gene Repression
… repression domain, although the role these co-repressor proteins play in suppression of MLL target gene activation has not been elucidated (Xia, Z 2003). In this study, the co-repressor proteins (HDAC and BMI1) that bind to MLL RD were examined to determine if CYP33 leads to the recruitment of …
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Exploiting Bacteriophages to Tackle Clostridium difficile Infection
… altered phenotype included the action of ФCD27 repressor proteins on the promoter regions of C. diffiicle toxin genes or regulatory elements, but affinity of a candidate repressor, ORF44, to PaLoc constituents was not demonstrated. Studies have also demonstrated the ability of ФCD27 to prevent …
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Transcriptional Regulation of Adult Neurogenesis by NRSF/REST and NeuroD1
… and NeuroD1. NRSF/REST, a transcriptional repressor that binds a specific NRSE site and recruits corepressors and chromatin remodeling machinery to repress its target genes, is critical for maintenance of the neural stem cell pool and for proper pacing of neuronal differentiation. NeuroD1, …
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Cell Type-Specific Contributions of FOXP1 to Human Cortical Development
Pages vi-xv are misnumbered as pages v-xiv, pages 89-129 are misnumbered as pages 87-127, and pages 130-174 are misnumbered as pages 124-168.
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Combinatorial Regulation of Signal-Induced CD45 Exon Repression by hnRNP L and PSF
CD45 is a hematopoetic-specific tyrosine phoshatase. In resting T cells three variable exons are partially repressed, and following antigen challenge, these exons are more highly repressed. Previous work identified the ESS1 silencer element that functions to mediate exon 4 silencing under resting …
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The Functional Characterization of the LysR-Type Transcriptional Regulator QseD and the SorC-Type Transcriptional Regulator LsrR in Enterohemorrhagic Escherichia coli
… that often involve intracellular regulatory proteins, such as the lysine regulator (LysR) type transcriptional (LTTR) family member QseA, EHEC is able to coordinate the expression of its multiple virulence factors [4]. These factors include the production of flagella that confer bacterial …
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MeCP2 and the Epigenetic Regulation of Excitatory Synaptic Transmission
… Mutations in one such gene, the transcriptional repressor methyl-CpG-binding protein 2 (MeCP2), lead to a form of mental retardation called Rett Syndrome (RTT). Though the MeCP2 protein is expressed ubiquitously, symptoms of RTT patients are primarily neurological, which include reduced mental …
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Delineating Mechanisms of Signal-Induced RNA Polymerase II-Transcription
Signal-induced transcriptional programs regulate critical biological processes through the precise spatio-temporal activation of inducible gene programs. Understanding the dynamics by which RNA Polymerase II precisely induces transcription to activate these programs is important for dissecting the …
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Compensation Between Foxp Transcription Factors Maintains Proper Striatal Function
Spiny projection neurons (SPNs) of the striatum are critical in integrating neurochemical information to coordinate motor and reward-based behavior. Mutations in the regulatory transcription factors expressed in SPNs can result in neurodevelopmental disorders (NDDs). Paralogous transcription …
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The Role of Polyploidy in the Liver and Its Implications for Cancer Therapy
The description of liver polyploidy dates back to the 1940s, but its functional roles are still largely unknown. Numerous observations and studies have suggested that liver polyploidy may participate in multiple biological processes, including regeneration, stress response, and cancer. However, …
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The Role of Twist2 in Physiologic and Pathologic Myogenesis
The file named "LI-DISSERTATION-2019.pdf" is the primary dissertation file. Two (2) supplemental video files are also available and may be viewed individually.