Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 221 for “"Repositioning"”.
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Nucleosome repositioning in glioblastoma
… regions that underwent GBM-specific nucleosome repositioning and showed that Principal Component Analysis (PCA) based on nucleosome occupancy values in these regions could be used for patient diagnosis. The results of my work have implications for future development of liquid biopsy assays for …
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Repositioning Manhattan office buildings
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 1989.
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Repositioning of astemizole for malaria
… activity). This Ph.D. project pursued a drug repositioning approach on Astemizole (AST, Figure 1), a second-generation antihistamine drug which was previously identified as an antimalarial agent by Chong et al., at the Johns Hopkins University School of Medicine through via a high-throughput …
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Accelerating antimalarial drug discovery through repositioning
… One possible short-term solution is drug repositioning, via screening existing FDA-approved (Food and Drug Administration agency) drug libraries for antimalarial activity. Towards this goal, two, fast, simple, and reliable in vitro SYBR Green-based drug susceptibility assays were …
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Drug discovery against malaria parasite: drug repositioning strategy
… to drug resistance. In this work, I used drug-repositioning strategy with bisphosphonates to discover a lead that is active against malaria in vivo. The developmental procedures include, in vitro high throughput screening, x-ray crystallography and other biophysical techniques. First, a …
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Drug repositioning and indication discovery using description logics
Drug repositioning is the discovery of new indications for approved or failed drugs. This practice is commonly done within the drug discovery process in order to adjust or expand the application line of an active molecule. Nowadays, an increasing number of computational methodologies aim at …
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Phased repositioning of a 1960's conference center
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Architecture, 1992.
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Empty Railcar Repositioning Subject to Travel Time Uncertainty
The empty railcars repositioning strategy generates no income but is crucial for a good service quality, it should then satisfy two main objectives: fullling the customer demand and generating as little expense as possible. Moreover, because of breakdown or heavy traffic, variation on travel times …
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Repositioning within indigenous discourses of transformation and self-determination
… of Education). Our research work has involved repositioning ourselves from dependence on Western research methodologies to a better understanding and application of kaupapa Māori conceptualisations of research. The thesis begins by identifying mainstream and kaupapa Māori events that have …
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An examination of hotel repositioning strategies : three case studies
… owner has the option to reposition the property. Repositioning is often triggered when a property is under-performing, suffering from financial distress and/or experiencing changes in ownership. The primary objective of repositioning is to improve the property's performance. The objective of this …
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Optimizing empty container repositioning in a truck-rail intermodal network
… moved by the transportation industry requires repositioning of empty containers. Empty container repositioning (ECR) describes the strategy for empty container relocation to reduce cost and satisfy demand. ECR costs the transportation industry billions of dollars per year worldwide, so the …
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Ontology-based methods for disease similarity estimation and drug repositioning
Human genome sequencing and new biological data generation techniques have provided an opportunity to uncover mechanisms in human disease. Using gene-disease data, recent research has increasingly shown that many seemingly dissimilar diseases have similar/common molecular mechanisms. Understanding …
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Analysing hotel repositioning through property renovation in the hospitality industry
This study addresses the renovation and repositioning activities of the hotel industry. Specifically, the primary focus of this study is to explore to what extent hoteliers deal with renovation as a repositioning tool, to explore the perception and practice of hoteliers, architects and interior …
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Repositioning teachers and learners in senior science for 21st century learning
This thesis explores how the turn towards ‘21st century learning’ might influence senior secondary science education in the context of high stakes summative assessment in Aotearoa New Zealand. Significant in the set of assumptions and ideals associated with 21st century learning is the expectation …
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The Impact Of Social Capital On Women’s Career Repositioning In Business
… and improves the understanding of women’s career repositioning with consideration of their social capital measures and behaviors, career satisfaction measures, and family life stage. The research question is: To what degree does social capital impact women’s ability to reposition their careers in …
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Exploring patient pressure relief, repositioning and transfer while in a bed
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-15 without embargo terms
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Repositioning real estate companies : from development to asset and property management
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Architecture, 1996.
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Repositioning Chinatown Las Vegas : theming authenticity and theory of boring architecture
China's surging economy compels cities worldwide to employ an extreme form of reverse colonization. A race is in progress to build the world's largest Chinatown. St. Petersburg and Dubai's are under construction and London is talking about it. Las Vegas belatedly joins the competition. The city …
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Design of an assist device for automated rolling and repositioning bedridden patients
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2002.
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