Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"Repopulation"”.
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Cell senescence and aging in carcinogenesis and liver repopulation
… of an experimental model of massive liver repopulation through hepatocyte transplantation. This approach was set up in our laboratory and is based on the administration of retrorsine (RS), a naturally occurring alkaloid, as a preconditioning treatment. Rat liver exposed to RS and then …
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The Impact of Clinically Relevant Culture on Human Haematopoietic Stem Cells: A Kinetic Analysis at Single Cell Resolution
… a purified LT-HSC subset. Importantly, long-term repopulation capacity is lost over culture, although the kinetics and molecular drivers of this process remain unclear. To address these questions, I perform single cell RNA-Seq, in vitro functional assays and in vivo transplantation in a time …
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Insulin-Like Growth Factor-Binding Protein 2 Supports Hematopoietic Stem Cell Expansion: From In Vitro to In Vivo
… of mouse HSCs. As measured by competitive repopulation analyses, there was a 48-fold increase in numbers of long-term repopulating mouse HSCs after 21 days of culture. This is the first demonstration that IGFBP2 stimulates expansion or proliferation of murine stem cells. Our finding also …
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Dynamic optimization of fractionation schedules in radiation therapy
… part of the thesis, we analyze the effect of repopulation on the optimal fractionation scheme. A dynamic programming framework is developed to determine an optimal fractionation scheme based on a model of cell kill due to radiation and tumor growth in between treatment days. We prove that the …
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Intravital Imaging of Dynamic Behaviors of Leukocytes in UVB-induced Skin Inflammation
… radiation, but rather promoted LC precursors’ repopulation to the epidermis after UVB treatment. In addition, depletion of neutrophils greatly diminished the magnitude of UVB-induced ear swelling, suggesting that neutrophils are crucial for UVB induced skin inflammation. Not only do our data …
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Studying the Clonal Origins of Drug Resistance in Human Breast Cancers
… by cell-cycle regulation and/or quiescent repopulation dynamics, drug induced chromatin remodelling or differential transcription factor binding, that can be transient or permanent in nature. This thesis will outline experiments using high complexity molecular barcodes to trace the fate of …
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Extending The Lifetime of Optically Stimulated Dosimeters For Use In Output Checks At Iroc- Houston
… a greater accumulated dose history. For charge repopulation, we find that the degree of charge repopulation is related to dose, time, and bleaching light though this effect is nonsignificant with the IROC the newly analyzed dose limit of ~15-20 Gy. We find that fractionations at 5 Gy and higher …
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Development of a Human Immune System from Hematopoietic Stem Cells in a Human/Mouse Xenogeneic Model
… organoid implant, there is minimal systemic repopulation with human T cells. Here I present evidence that transplantation of autologous human hematopoietic fetal liver CD34+ cells into NOD/SCID mice previously implanted with fetal thymic and liver tissues results in long-term, systemic human …
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PRE-CLINICAL MODELING OF CELL AND GENE THERAPY OF FANCONI ANEMIA
… normal levels of precursor cells despite repopulation defects post-transplantation. The only exception was in recipients transplanted with bone marrow from aging Fancc-/- mice, which displayed slightly reduced lymphocyte precursor cell numbers. Consequently, the repopulation defects of …
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Analysis of nerve terminal dysfunction in autoimmune neuropathy
… within 20 minutes of complement exposure. Repopulation of the NMJs with GFP-positive cell bodies is first evident at day 2. The origin of these returning Schwann cells is discussed, and three possible sources are considered – the last myelinating Schwann cell, non-myelinating Schwann cells …
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EFFECTS OF THE LIVER MICROENVIRONMENT ON HUMAN LIVER SINUSOIDAL ENDOTHELIAL CELLS DURING IN VITRO CULTURE
… human LSECs (hLSECs) in vitro for eventual repopulation of the liver sinusoidal endothelium of a clinically relevant liver scaffold. We examined the effects of three specific aspects of the liver microenvironment on expansion and maintenance of hLSECs in vitro: (1.) extracellular matrix …
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Ultraviolet Radiation and Carotenoid Pigmentation in Symbiotic Anthozoans
… radiation (UVR) photoprotectants and 2) the repopulation and photoadaptive response of symbiotic algae (i.e., zooxanthellae) after bleaching. An experiment was conducted to partition the effects of UVA (320 - 400nm), photosynthetically active radiation (PAR; 400-700nm) and host feeding on the …
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Characterisation of human Haematopoietic Stem Cell differentiation and exit from quiescence at single cell resolution
… and display infrequent but durable repopulation capacity. Second, I demonstrate that a drastic transcriptional remodelling reflective of the fast metabolic activation seen in ex-vivo cultured HSCs occurs during quiescence exit, and independently of cell cycle progression. In-vivo …
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The Role of Merlin and Apicobasal Polarity In Endometrial Development and Homeostasis
… tissues like the epidermis. The continual repopulation of the endometrium after each menstrual cycle requires a constant reorganization of cell polarity and adhesion. The endometrium consists of a luminal epithelium that postnatally gives rise to the distinct glandular epithelium. …
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Music, Video and Perception: An investigation into shaping attitudes toward fish and their natural habitat
… questions about ocean conservation and fish-repopulation, their knowledge about non-native species, and a series of questions assessing their attitudes toward the marine environment, which consisted of seven different categories (i.e., naturalistic, moralistic, ecologistic, or humanistic, …
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Misura della connettività e della dispersione dell’aragosta rossa Palinurus elephas (Fabricius, 1787) in Sardegna con l’uso di marcatori genetici STRs e mitocondriali
… 1998. This results enforces the success of the repopulation action. Moreover, mitochondrial marker did not reveal any significant structure among sampling sites, whereas the individuals seem to belong to the same unique population. From a demographic point of view, Su Pallosu sample seems to be …
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Granulocyte Colony-Stimulating Factor Minimizes Negative Remodeling of Decellularized Small Diameter Vascular Graft Conduits but Not Medial Degeneration
… layer was also examined for signs of cellular repopulation and changes in the elastic fiber morphology. RESULTS: Intergroup comparison of the intimal composition showed relatively sparse collagen content and predominance of α –actin staining cells in the +G-CSF group. The medial layer in the 2 …
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Influence of mitochondrial membrane potential on the cryopreservation survival of hepatocytes
… studies, bioartificial liver devices, and repopulation of damaged livers as an alternative to transplantation. However, these cells are scarce and difficult to maintain in culture for prolonged periods of time. Banks of cryopreserved liver cells would significantly alleviate issues of …
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Investigating the Reconstitution and Function of Peritoneal Cavity Macrophages after LPS-induced Peritonitis
… reporter mouse were used to illustrate the repopulation of endogenous LPMs and newly recruited monocytes that contribute to the macrophage pool upon resolution of inflammation. My findings suggest that LPMs concentrate and localize at ‘milky spots’ of the omentum. Upon resolution of …
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Regulation of cell cycle and differentiation by ASCL1 in Glioblastoma
… as this would cause them to lose their long-term repopulation potential and would therefore limit tumour growth. In this study, I investigated if the transcription factor ASCL1 could drive neuronal differentiation in GSCs. ASCL1 is a key regulator of neurogenesis in the developing CNS and is …
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