Global ETD Search
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Showing 1 to 4 of 4 for “"Replicative aging"”.
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Understanding The Mechanism of Genomic Instability During Replicative Aging In Budding Yeast
<p>Aging brings a gradual decline in molecular fidelity and biological functionality, resulting in age related phenotypes and diseases. Despite continued efforts to uncover the conserved aging pathways among eukaryotes, exact molecular causes of aging are still poorly understood. One of the most …
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Machine Learning for Lifespan Inference from Time-Lapse Microfluidic Images of Dividing Yeast Cells
… increase the speed and quality of yeast replicative lifespan measurements that are related to aging. One major challenge is to efficiently convert large volumes of time-lapse images into quantitative measurements of yeast cell lifespan measurements. To address these issues, we developed …
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Tvorba proteinových granulí v diferencovaných buňkách kvasinkových kolonií
… state of the cell (e.g. chronological and replicative aging), but also to changing environmental conditions and to cellular responses to stress factors. A relatively large fraction of proteins relocalizes to some type of protein granule during the lifespan of the cell. Granule formation can …
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DNA repair and genomic instability in yeast aging
Aging is a universal process that occurs in eukaryotic organisms. Many features of aging, including the genetic pathways involved in aging, appear to be evolutionarily conserved. Extrachromosomal rDNA circles (ERCs) have been identified to be a cause of replicative aging in budding yeast S. …