Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Replication timing"”.
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Role of DNA replication timing in gene expression and chromatin organisation
… conserved temporal pattern. This pattern of DNA replication is altered during development and differentiation and can be dysregulated in cancers. While temporal changes in genome duplication are associated with altered transcription and chromatin organisation, it is still unknown whether DNA …
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DNA Replication of the Male X Chromosome Is Influenced by the Dosage Compensation Complex in Drosophila melanogaster
<p>Abstract</p><p>DNA replication is an integral part of the cell cycle. Every time a cell divides, the entire genome has to be copied once and only once in a timely manner. In order to accomplish this, DNA replication begins at many points throughout the genome. These start sites are called …
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UNCOVERING STRUCTURE-FUNCTION RELATIONSHIPS IN CHROMATIN ARCHITECTURE
… processes such as gene expression and DNA replication, which are crucial to establishment and maintenance of cell identity in human development. Recent technological advances have enabled the creation of high-resolution maps of chromatin architecture genome-wide from which to test new …
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Consequences of partial chromosome re-replication in mammalian cells
To prevent re-replication of DNA in a single cell cycle, the licensing of<br/>replication origins by Mcm2-7 is prevented during S and G2 phases. Metazoans<br/>achieve this by cell cycle regulated proteolysis of the essential licensing factor<br/>Cdt1 and formation of an inhibitory heterohexameric …
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Chromosome dynamics of the early meiotic cell cycle in S. cerevisiae
… between pre-mitotic and pre-meiotic DNA replication, pre-meiotic S phase is longer than pre-mitotic S phase, suggesting that meiosis-specific events regulate the rate of DNA replication. Additionally, after DNA replication, homologous recombination is initiated by the introduction of …
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The role of Cdc7 and cyclin-dependent kinases in DNA replication and S phase
… and processes ensure genomic stability. DNA replication takes place during S phase to faithfully duplicate a cell’s genetic material. In eukaryotes, S phase onset involves the initiation of numerous licensed replication origins across the genome and requires the activities of two protein …
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Patterns of somatic genome rearrangement in human cancer
… delineated by structural class, size, and replication timing. In Chapter 5, I move on to the complex SV clusters (largely set aside throughout Chapters 2—4) , and develop an improved breakpoint clustering method to subdivide the complex rearrangement landscape. I propose a raft of summary …
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Pathogenicity and selective constraint in the non-coding genome
… germline features including recombination rate, replication timing, sequence context, and histone marks which greatly outperforms models based on sequence-context alone. - I find evidence for widespread purifying selection in the non-coding genome that is correlated with nucleotide-level …
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Re-replication in the Absence of Replication Licensing Mechanisms in Drosophila Melanogaster
… once and only once per cell division. DNA replication is tightly regulated by replication licensing mechanisms which ensure that origins only initiate replication once per cell cycle. Disruption of replication licensing mechanisms may lead to re-replication and genomic instability. …
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Role of ORCA and ORC in chromatin organization and DNA replication
… and this is essential for the initiation of DNA replication. In human cells, ORC is a highly dynamic complex with many separate functions attributed to sub-complexes or individual subunits of ORC including heterochromatin organization, telomere and centromere function, centrosome duplication and …
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Advancements in genome engineering and applications in mammalian systems
… which had approximately an hour delay in replication timing. Moreover, fewer doublets were observed from CRISPR-Cas9 labeling over the live imaging acquisition, implying a possibility that CRISPR-Cas9 perturbed sister locus separation. Generally, these imaging methodologies can efficiently …