Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Replication restart."”.
-
Characterization of two Bacillus subtilis proteins required for the initiation, restart, and control of DNA replication
… These abnormalities may result from a defect in replication restart at damaged or stalled replication forks. Thus, whereas dnaBS3 71P suppresses the defects of mutant cells that cannot initiate or restart replication, expressing DnaBS371P in wild-type cells causes defects in initiation and …
-
DDI1/2 and RTF2-Dependent Regulation of RNASE H2 at the Replisome Ensures Genome Stability
… DNA Damage Inducible 2 (DDI2), are active in the replication stress response (Kottemann et al., 2018). Under conditions of replication stress, DDI1/2 function to remove Replication Termination Factor 2 (RTF2) from the replisome. Persistence of RTF2 at the replisome compromises the replication …
-
Uncovering Phosphorylation Circuitries that Control DNA Replication Fork Dynamics
… genetic information to the daughter cell. DNA replication is a fundamental process that frequently encounters challenges from exogenous and endogenous sources. Barriers to replication slow down DNA synthesis and threaten the genetic integrity and viability of the cell. Cells are equipped with …
-
Uncovering vital molecular contacts within the replisome and characterizing fail-safe mechanisms ensuring genomic stability in E. coli.
… α-Pol III to the DnaB helicase for efficient DNA replication in E. coli. Therefore, disrupting interactions between τ-CLC and α-Pol III also disrupts coordination with the DnaB helicase. To probe this phenomenon, we initiated our study through in vitro investigations by using site-directed …
-
Cloning, Expression and Purification of the Different Human Haptoglobin Chains and Initial Characterization by Mass Spectrometry
… that is an essential component of the PriA replication restart pathway. Very little is known about this protein, its structure, and its actual mode of function. Several attempts to crystallize this protein have been met with inconclusive results thought to be due to regions of intrinsic …
-
Functions of RTF2 in DNA Replication and Checkpoint Control
… has uncovered one such dynamic process at replication forks experiencing replication stress, by which proteasome shuttle proteins DNA damage inducible 1 and DNA damage inducible 2 (DDI1/2) regulate the level of replication termination factor 2 (RTF2) at the replisome. When RTF2 is retained …