Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Replication licensing"”.
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Re-replication in the Absence of Replication Licensing Mechanisms in Drosophila Melanogaster
… once and only once per cell division. DNA replication is tightly regulated by replication licensing mechanisms which ensure that origins only initiate replication once per cell cycle. Disruption of replication licensing mechanisms may lead to re-replication and genomic instability. …
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A study of the relationship of the internal endocrine environment to the p53 network, cyclin D1 and replication licensing proteins in breast cancer
… and prognostic association of cyclin D1 and replication licensing proteins (mcm2 and geminin) in invasive breast cancer. Hypothesis The endocrine environment may be critical in the development and efficacy of treatment in breast cancer. Oestrogen has the potential to modulate the function of …
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Investigating the Mechanism of Geminin Inactivation
DNA replication is regulated throughout the cell cycle to ensure that the entire genome is replicated once per cell cycle. Replication licensing is a key process required for the initiation of DNA replication. Replication licensing refers to the chromatin loading of an essential replication factor, …
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KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
… maintenance proteins (MCMs), a complex of DNA replication licensing factor required for cellular DNA replication.
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ORCA/LRWD1, a novel player in the initiation of eukaryotic DNA replication
Accurate DNA replication is key to maintaining genome stability in all living species. In eukaryotes, the duplication process starts with the formation of the pre-replicative complex (pre-RC) prior to S phase, followed by the transition to the pre-initiation complex (pre-IC) that is required for …
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Proteomic profiling of matched normal and tumour tongue biopsies from smokers and non-smokers. Oncoproteomic applications for oral tongue squamous cell carcinoma biomarker discovery
… 8 (KRT8), Lipocalin-1 (LCN1) and DNA replication licensing factor MCM2 (MCM2) were identified as biologically associated with smoking compared to non-smoking, providing viable targets for verification by immunochemical methods which further supported the proteomic data. Overall, the …
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Proteomic profiling of matched normal and tumour tongue biopsies from smokers and non-smokers. Oncoproteomic applications for oral tongue squamous cell carcinoma biomarker discovery
… 8 (KRT8), Lipocalin-1 (LCN1) and DNA replication licensing factor MCM2 (MCM2) were identified as biologically associated with smoking compared to non-smoking, providing viable targets for verification by immunochemical methods which further supported the proteomic data. Overall, the …
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Proteomic profiling of matched normal and tumour tongue biopsies from smokers and non-smokers. Oncoproteomic applications for oral tongue squamous cell carcinoma biomarker discovery
… 8 (KRT8), Lipocalin-1 (LCN1) and DNA replication licensing factor MCM2 (MCM2) were identified as biologically associated with smoking compared to non-smoking, providing viable targets for verification by immunochemical methods which further supported the proteomic data. Overall, the …
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Spatiotemporal dynamics of cell division in intestinal homeostasis
… crypt compartments by investigating the DNA Replication Licensing System. The licensing system is a master regulator of proliferative fate in all cells in adult tissue. At its core is the regulated loading of the Mcm2-7 protein complex onto origins of replication exactly once per cell cycle. …
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Mechanisms of genomic stability maintenance in fission yeast
DNA replication consists of two distinct steps: the licensing step during the G1 phase and the initiation step at the G1 to S transition point. During licensing, two inactive complexes of the replicative helicases, MCMs, are loaded onto all the potential origins of replication (ORIs), through the …
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Μελέτη της έκφρασης δεικτών του κυτταρικού κύκλου καθώς και αγγειογενετικών παραγόντων σε ασθενείς με ηπατοκυτταρικό καρκίνωμα, οι οποίοι υπέστησαν μερική ηπατεκτομή για θεραπευτικούς λόγους. Συσχέτιση με την μετεγχειρητική επιβίωση των ασθενών και τους κλασσικούς προγνωστικούς δείκτες της νόσου
Το ΗΚΚ αποτελεί ένα πολύ συχνό και συνάμα εξαιρετικά επιθετικό νεόπλασμα με χαμηλά ποσοστά επιβίωσης. Ως αποτέλεσμα, η καλύτερη κατανόηση της βιολογίας της νόσου και η εύρεση προγνωστικών-προβλεπτικών βιοδεικτών και νέων θεραπευτικών στόχων έχει ιδιαίτερο ερευνητικό ενδιαφέρον. Το ΗΚΚ αναπτύσσεται …