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Showing 1 to 1 of 1 for “"Replication Repair Deficiency"”.
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Studies of Replication Repair Deficient Brain Tumorigenesis Using Mouse Modeling
Replication repair deficiency (RRD) is a pan-cancer mechanism caused by germline and/or somatically acquired deficiency in the replication repair machinery – DNA polymerase proofreading and the mismatch repair (MMR) system. Germline monoallelic (Lynch Syndrome, LS) or biallelic (Constitutional …