Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Replication Fork Protection"”.
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Keeping It Together and Taking It Apart: Structural Investigations of Replisome Complexes Involved in DNA Replication Fork Protection and Termination
DNA replication is an essential cellular process whose dysregulation is implicated in severe human disease, including cancer. Broadly, DNA replication involves the unwinding of the DNA double-helix, allowing DNA polymerases to use each unwound strand as a template for nascent DNA synthesis; the …
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Mechanisms of human RAD51 regulation by RAD52 and BRCA2
… to mediate homologous DNA recombination (HR) and replication fork protection, processes vital in human cells for the maintenance of genome stability. RAD51 assembly is controlled by two key mediator proteins in eukaryotic organisms – the tumour suppressor, BRCA2, and RAD52. Recent evidence …
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Transcriptional and Chromatin Disorientation Associated with BRCA2 Inactivation
… via homologous recombination repair, DNA replication fork protection, and R-loop resolution. However, the mechanism by which BRCA2 inactivation causes cancer remains unclear. In this study, using RNA-seq and ATAC-seq I investigated whether BRCA2 acts as a tumour suppressor via regulating …
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Molecular Characterization of Novel Mutations in Fanconi Anemia Patients
… revealed that this domain is important for replication fork protection, and to a lesser extent canonical homologous recombination. FA is a very heterogeneous disorder and as a consequence of overlapping clinical features, patients may be misdiagnosed with FA in lieu of another DNA repair or …