Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Replication Cycle"”.
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RESISTANCE TO VESICULAR STOMATITIS VIRUS IS INTRINSIC TO PC3 PROSTATE CANCER CELLS AND CAUSES INHIBITION OF EARLY STEPS OF THE VIRUS REPLICATION CYCLE
… the timing of the different steps of the virus replication cycle in PC3 prostate cancer cells (VSV-resistant cells) to LNCaP prostate cancer cells (VSV-sensitive cells). My experiments revealed that several early steps of the viral replication cycle are delayed in PC3 cells, including virus …
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A comparison study of efficacy of food sanitizers with fresh leafy vegetables with different surface properties and analysis of the rotavirus replication cycle after inactivation by food sanitizers
… effects of the sanitizers on the rotavirus replication cycle at a molecular level. As a result, while differences of sanitation efficacy on rotaviruses on the three cultivars were observed by Tsunami® 100, malic acid + TDS had similar disinfection efficacies on rotaviruses attached onto the …
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Multiscale Modelling of Environmentally Transmitted Infectious Diseases
… study represent infectious disease systems with replication-cycle at microscale (i.e. ruminant paratuberculosis) and infectious disease systems without replication cycle at the microscale (i.e. human ascariasis). Firstly, the author develop a single-scale model at the host-level that we …
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An investigation of post-translational modification of human papillomavirus E4 and the role of modified E4 proteins during the virus life cycle
… proposed to be a major regulator of the HPV life cycle and the multiple and diverse activities associated with E1^E4 suggest that it is a multi-functional protein. This thesis has sought to address the hypothesis that phosphorylation and proteolysis contribute towards the pleiotrophic functions of …
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X-ray diffraction analysis of gene V protein encoded by filamentous bacteriophage Ff
… protein and it plays an important role in the replication cycle of the phage. The crystal structure of the gene V protein was determined using multiwavelength anomalous diffraction on the selenomethionine-containing wild-type and isoleucine-47 $\to$ methionine mutant proteins with x-ray …
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Using Altered Fidelity Viruses to Study Viral Attenuation and Population Genetics During Vertebrate Host Infection
… arthropod and vertebrate hosts for the host life cycle of an arbovirus constrains its evolution. For the viral population to survive in two hosts, the ability to produce genetic diversity within the population is essential. RNA viruses contain an RNA dependent RNA polymerase (RdRp) that creates a …
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Investigations of the molecular determinants of maize streak virus replication
… mechanism, which initiates at the origin of replication located within the long intergenic region (LIR). The viral replication associated-protein (Rep) in conjunction with the host's DNA replication machinery is responsible for the initiation and termination of the replication cycle from a …
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Mechanisms of retroviral replication
… of viral RNA is an essential step of retroviral replication cycle. Extensive biochemical and genetic analyses suggest that majority of retroviruses employ similar mechanisms for specific RNA packaging. Better understanding of mechanisms of this process may help to develop new anti-retroviral …
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Investigation of azithromycin analogues and proteasome-like inhibitors as quick-killing antimalarials
… death’, where the parasite dies in the second replication cycle (4 days). Azithromycin has also been shown to inhibit invading merozoites and kill blood stages within the first replication cycle (2 days) via an unidentified mechanism, proposed to be independent of delayed death. Thus, we …
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Characterization of 5 UTR splicing and the CGI in HIV-2 RNA
<p>HIV-2 tightly regulates several steps of its replication cycle via regulatory elements found within the 5 untranslated region of HIV-2 genomic RNA. Two elements of interest are the 5 UTR intron and the proposed long distance base pairing interaction between the C-box and G-box termed the CGI. …
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Characterization of 5 UTR splicing and the CGI in HIV-2 RNA
<p>HIV-2 tightly regulates several steps of its replication cycle via regulatory elements found within the 5 untranslated region of HIV-2 genomic RNA. Two elements of interest are the 5 UTR intron and the proposed long distance base pairing interaction between the C-box and G-box termed the CGI. …
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Structural Basis For Poliovirus Cloverleaf-Mediated Regulation Of Genome Replication
… single-stranded RNA genomes. During the viral replication cycle, it is critical that the virus generates the appropriate amounts of viral proteins and genomic RNA. Upon entry in the cell, the viral genome is first used as a template for translation of viral genes and then as a template for …
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Kinetics and mechanisms of bacteriophage PR772 inactivation by monochloramine
… Molecular analyses at various stages of the replication cycle were used to determine which viral replication step was hindered by monochloramine disinfection at pH 8.0-30.0℃ (baseline condition) and pH 10.5-30.0℃ (high pH and high temperature condition). The results showed that early mRNA …
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Investigation of the Vesicular Stomatitis Virus Matrix Protein: Uncoating and Assembly
… rhabdovirus to study viral entry, transcription, replication, and assembly. The matrix protein (M) of VSV is a central component of the viral replication cycle. While being the smallest of the viral proteins it is multifunctional and is involved in uncoating, cytopathic effects (CPE), and assembly …
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Regulation of late and very late gene expression in both lytic and persistent baculovirus infections
… is an insect-specific pathogen, with a biphasic replication cycle generating both budded viruses (BVs) and occlusion bodies (OBs). While BVs are released from the cell membrane mainly in the late phase of infection, OBs are produced in the subsequent very late phase and released after cell lysis. …
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Characterisation and expression of ORF2 in genome segment 10 of African horse sickness virus
… functional analysis of this protein in the AHSV replication cycle.
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Isolation, identification, and in silico analysis of mycobacteriophage OKCentral2016.
… below 55??C and under neutral pH conditions. The replication cycle took approximately 4 hours to complete under ideal growing conditions. I also examined the effect of OKCentral2016 on biofilms. OKCentral2016 did not infect any pathogenic mycobacteria tested (M. avium, M. abscessus, M. …
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Structural and biophysical studies of HIV-1 Rev protein
… early phase\r\nto the late phase of the viral replication cycle. Because it is prone to form filaments at\r\nvery low concentration, the X-ray crystallography or NMR approaches to solving Rev\r\nstructure are very difficult. In my dissertation studies, I have designed several …
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Defining the Influence of Host Cell Proteostasis Networks and Temperature on Influenza Evolution
… their evolution. Furthermore, the entire viral replication cycle takes place within the host cell. Therefore, the environment of the host, including factors such as temperature, can influence the evolutionary trajectory of viral proteins. The overarching goal of my thesis work is to better …
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The Intracellular Kinetics of HIV-1 Replication
The rate of HIV-1 replication has an impact on the viral loads patients have and the time it takes for an infection to progress to AIDS. This replication rate is defined partly by the time it takes an infected cell to begin producing new infectious virus, and this, in turn, is defined by the time …
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