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Showing 1 to 3 of 3 for “"RepliVAX"”.
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Using the single-cycle flavivirus particle replivax to study flavivirus replication and immune response
RepliVAX is a novel single-cycle flavivirus (SCFV) vaccine platform, which contains a deletion in the capsid (C) gene of West Nile virus (WNV) that prevents the formation of infectious particles, unless the C gene is trans-complemented by a WNV C-expressing cell line. RepliVAX immunization results …
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Characterization of single-cycle flavivirus particles for use as a vaccine to prevent West Nile disease and to examine immune responses to flavivirus infection
… To address these needs we have developed RepliVAX WN, a single-cycle flavivirus (SCFV)-based vaccine to prevent West Nile disease. RepliVAX WN contains a C-deleted WNV genome, and is produced in trans-complementing cell lines that express WNV C. When used for vaccination, RepliVAX WN …
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The role of TLR3- and MyD88-dependent signaling in the development of anti-West Nile virus adaptive immune responses induced by a vaccine candidate, RepliVAX WN.
… ultimately shape the adaptive immune response. RepliVAX WN, a single-cycle flavivirus (SCFV) vaccine candidate derived from West Nile virus (WNV), is intrinsically adjuvanted with multiple PAMPs and induces vigorous anti-WNV T and B cell responses. However, the innate mechanisms that link …