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Showing 1 to 20 of 136 for “"Reperfusion injury"”.
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Mitochondrial Metabolism in Ischaemia Reperfusion Injury
Ischaemia reperfusion (IR) injury is caused by the re-introduction of oxygenated blood flow to tissues after a period of ischaemia. It is an inevitable consequence of organ transplantation, where its severity contributes to reduced levels of graft function and survival. There are no clinically …
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Treatment of Ischemia Reperfusion Injury with RNA Interference
Ischemia reperfusion injury (IRI) occurs during transplantation and causes apoptosis and inflammation. The purpose of this research was to determine the effect of caspase-3, complement 3, and RelB gene silencing in the reduction of IRI using an in vitro model. LLC-PK1 cells were used along with …
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Novel Strategies in Cardioprotection against Ischemia/Reperfusion Injury
… where it plays an important role in ischemia-reperfusion (I/R) injury. Considerable progress has been made towards identifying physiological and pharmacological agents that play a key role in myocardial preconditioning against I/R injury and also elucidating the molecular changes leading to …
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Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… anti-apoptotic properties on cerebral ischemia injury. HNG reduced infarct volume after ischemia/reperfusion injury with pre-treatment or post-treatment (i.c.v. and i.p.) in a middle cerebral artery occlusion model in mice and decreased neurological deficits induced by ischemia. The protection …
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Flavonoid protection of cardiac cells against ischemia-reperfusion injury
Myocardial ischemia-reperfusion injury occurs following the majority of cardiac events including myocardial stenosis and heart surgeries. As reactive oxygen species are one of the major contributors to ischemia-reperfusion injury, strategies to prevent their effects may be directed towards …
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Improvement of liver transplantation by reducing preservation-reperfusion injury
… artery and venous blood via the portal vein. The reperfusion injury which occurs after ischemia, has been studied to only a limited extent in the liver. In particular, the relative contribution of the portal venous blood and the hepatic arterial blood to the reperfusion injury has not been …
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Early Mediators of Cutaneous Ischemia Reperfusion Injury: A Mouse Model
… to be the repetitive incidence of ischemia reperfusion injury.A mouse model of cyclic ischemia reperfusion was employed to examine the initiation events in the pathology of chronic wounds. Mice were subjected to eight hours of magnetic skin compression via four cycles of two-hours ischemia …
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Cardiovascular Risk, Remote Ischemic Postconditioning, and Endothelial Ischemia-Reperfusion Injury
… stimulus that is thought to reduce reperfusion injury associated with heart disease. However, certain animal models of cardiometabolic risk factors such as dyslipidemia, diabetes, and hypertension suggest the beneficial effects of rIpost to lessen reperfusion injury may be …
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The central role of the neutrophil in ischaemic/reperfusion injury
… may lead to both local and remote tissue injury characterized by oedema, increased microvascular permeability to protein and degradation of connective tissue components. This damage is probably caused by the accumulation and inappropriate activation of neutrophils which occurs when the …
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Mitochondrial Dynamics: Exploring A Novel Target Against Myocardial Ischemia-Reperfusion Injury
… mediator of cell fate in the setting of ischemia-reperfusion (IR) injury, and, ii) inhibition of DRP1 and mitochondrial fission provides cardioprotection against IR injury. However, the precise role of DRP1 translocation to mitochondria in the pathogenesis of myocardial ischemia-reperfusion injury …
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Investigation Of Posttranscriptional Regulation After Global Brain Ischemia And Reperfusion Injury
… revived after cardiac arrest is ischemia and reperfusion (I/R) injury in the brain. Survival after brain I/R injury depends on the expression of new stress response proteins such as heat shock protein 70 (HSP70). Little is known about why recovering neurons are able to express new stress …
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Proteomic Discovery of Functionally Important Pathways in Myocardial Ischemia-Reperfusion Injury
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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α-Lipoic Acid Attenuates Ischemia Reperfusion Injury of the Rat Liver
107 Ischemia reperfusion injury (IRI) represents a major clinical problem in liver transplantation and resection. Main pathophysiological events during this injury comprise depletion of ATP, Kupffer cell activation with subsequent formation of reactive oxygen species and inflammatory response. …
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Mitochondrial dysfunction during ischaemia reperfusion injury in models of organ transplantation
… during this surgical procedure, ischaemia reperfusion injury (IRI), is still a major contributor causing poor outcome. Ischaemia arises due to the lack of blood supply, leaving the tissue without oxygen and substrates, which are crucial for energy generation. Upon reperfusion with …
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Investigating complex I dynamics and ROS production in ischaemia-reperfusion injury
Ischaemia-reperfusion (IR) injury is caused paradoxically when the flow of oxygenated blood to an organ is restored after a period of restricted blood supply (ischaemia) in the course of a heart attack, stroke or organ transplantation. Mitochondria play a central role in the pathology of IR injury …
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Apoptosis in the equine small intestine following experimental ischemia-reperfusion injury
… intestine subjected to experimental ischemia-reperfusion injury and determining if use of an angiotensin converting enzyme inhibitor (enalaprilat) would ameliorate the apoptotic response. It was designed to determine if mucosal epithelial cells undergo apoptosis during the ischemia phase and …
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