Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Repair pathway choice"”.
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53BP1 and double-strand break repair pathway choice in cancer
… (DSB) is principally the result of two competing repair pathways. The Tumour Protein P53 Binding Protein 1 (TP53BP1) gene product plays a central role in DSB repair pathway choice, promoting non-homologous end-joining (NHEJ) and counteracting homologous recombination (HR). As with all DNA damage …
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ROLE OF POLO KINASE CDC5 IN DNA DAMAGE PROCESSING AND REPAIR PATHWAY CHOICE.
Le Polo-chinasi (Polo-Like Kinases; PLK) sono regolatori del ciclo cellulare in tutti gli eucarioti e sono state implicate nel mantenimento della stabilità genomica. La scelta ed efficienza dei meccanismi di riparazione del DNA dipendono dalla progressione nel ciclo cellulare, ma i meccanismi …
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Evaluating Chemical Crosslinking as a Tool for Enhancing DNA Damage Repair Interactome Analysis
Eukaryotic cells can repair DNA Double-Strand Breaks (DSBs) through a number of mechanisms, including end resection-mediated pathways and non-homologous end joining (NHEJ). An End-Bridging Complex (EBC) comprised of elements from both end resection and NHEJ may be the first complex recruited to DSB …
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53BP1/Shieldin Counteract DSB Resection Through Fill-In Synthesis
… The role of 53BP1 in double strand break (DSB) repair outside of these three well-studied contexts is less clear, though it has been proposed that 53BP1 acts as a master regulator of so-called "DSB repair pathway choice," promoting classical non-homologous end-joining (cNHEJ) at the expense of …
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The Development of Novel Apurinic/Aprymidinic Endonuclease/Redox-factor 1 Inhibitors for the Treatment of Human Melanoma
<p>Apurinic/apyrimidinic DNA repair endonuclease-1 (APE1), first recognized as an important DNA excision repair enzyme, is also known as Redox Factor-1 (Ref-1) involved in the activation of many nuclear transcription factors in both redox-dependent and independent manner. It has been …
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Investigation of replication fork progression and re-replication fork instability at the Drosophila follicle cell amplicons
… all subsequent forks, suggesting efficient break repair is required for continued fork movement at the amplicons. To define the pathways responsible for maintaining re-replication fork elongation, we developed the half-maximum distance analysis to measure global fork progression at each site of …