Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Repair complex"”.
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DNA double-strand break repair studied by atomic force microscopy
… of DNA damage. The conserved Mre11-Rad50 DNA repair complex enables the catalytic activities of the Mre11 nuclease and the Rad50 ATPase to function together to coordinate the recognition and processing of DSBs prior to the recruitment of long-range end-resection machinery required to trigger …
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Light-induced modulation of DNA recognition by the Rad4/XPC damage sensor protein.
… come together to form specific biological complexes and how the assembly/disassembly of such complexes are regulated are key to understanding any biological process. Characterization of such dynamical processes is challenging as it necessitates means to rapidly and specifically spark the …
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Investigating the protein targets of the neuroprotective E3 ligase, CHIP
… proteins that are required for membrane repair and maintenance of membrane homeostasis. Given these functions, several types of membrane damage assays were conducted and suggested that CHIP KO cells are more sensitive to damage, despite retaining the ability to repair. This impairment in …
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Restriction-Modification and CRISPR-Cas Systems: Cooperation Between Innate and Adaptive Immunity in Prokaryotes
… Additionally, I show that the host DNA repair complex, AddAB, can process these breaks, which further enhances spacer acquisition. Finally, I follow the dynamics between RM and CRISPR-Cas during the chain of events that occur upon viral infection. I demonstrate that although the RM …
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Understanding The Repair Mechanisms at Ionizing Radiation-induced Damage in The Human Genome
… and homologous recombination are major DSB repair pathways which have been extensively characterized over the past decades, contribution of error-prone alternative end joining (Alt-EJ) at X-ray-induced DNA damage is poorly characterized and underestimated. Moreover, how repair of oxidative …
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Mechanisms and regulation of dsDNA break repair in the Sulfolobus genus of thermophilic archaea
… chemical and mechanical damage. The ability to repair the lesions sustained is essential for all life. Double stranded DNA (dsDNA) breaks are especially toxic as both antiparallel strands of DNA are severed. The most high fidelity mechanism available to repair this damage is homologous …