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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Reovirus"”.
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Cellular determinants of reovirus entry and infection
Efficient entry is a critical determinant of reovirus oncolysis. While a model for the entry of reovirus virions has been described, the method by which partially uncoated intermediate subviral particles (ISVPs) enter host cells remains unknown. Biochemical studies have suggested that ISVPs can …
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A MODEL SYSTEM FOR THE CONCENTRATION OF REOVIRUS FROM AQUEOUS ENVIRONMENTS
… method for the routine isolation of reovirus from model aqueous systems was developed. Reovirus was found to be stable within a pH range of 3 to 10, with a minimum loss of viability. A slight hydrogen ion excess minimized virus aggregation phenomena and promoted efficient adsorption …
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Animal and Plant Viruses with Double-Stranded Ribonucleic Acid
<p>Reoviruses occur widely in the respiratory and enteric tracts of man and animals, but their relation to disease is not clear. The present study concerns the physical-chemical characteristics and interaction with cells of reovirus type 3. A main objective of the study is to relate some of the …
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Predicting the triple beta-spiral fold from primary sequence data
… - one from Adenovirus and the other from Reovirus. There is evidence that the fold also occurs in Bacteriophage SF6. In this thesis, we present a computational analysis of the Triple β-Spiral fold. Our goal is to discover new instances of the fold in protein sequence databases. In Chapter …
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Characterizing the RNA Editing Specificityof ADAR Isoforms and Deaminase Domains In Vitro
… was also performed, using HEK 293T total RNA and reovirus T1L RNA as substrates for the purified ADAR constructs. An adapted sequencing library preparation was successfully used to identify and count individual editing events in reovirus T1L RNA, and further improvements are required to generate …
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Viral Inhibition of Mammalian Cell DNA Synthesis
… mengovirus, Newcastle disease virus, and reovirus type 3. The general method of analysis used and the results obtained are discussed within the framework of the model presented in the Introduction.</p>
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Molecular characterization of economically important poultry viruses in western Canada
Avian Reovirus (ARV), Chicken Astrovirus (CAstV), and Hemorrhagic Enteritis Virus (HEV) are important enteric pathogens affecting poultry production around the world. These agents are the causative agents of Viral Arthritis (VA), White Chick Syndrome (WCS), and Hemorrhagic Enteritis (HE), …
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Increased Apoptosis in the Host By Guanidine Hydrochloride Treatment of Infectious Pancreatic Necrosis Virus
… capsid induced apoptosis. Different strains of Reovirus, a naked double stranded RNA virus similar to Infectious Pancreatic Necrosis Virus (IPNV), have also been treated with GuHCI to show inactivation of ơ1 protein, responsible for haemagglutinin, without disrupting other capsid proteins. …
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THE ADENOVIRUS E1B-55K AND E4ORF6 PROTEINS LIMIT PKR-MEDIATED EIF2A PHOSPHORYLATION DURING THE LATE PHASE OF INFECTION
… In support of these findings, expression of the reovirus σ3 dsRNA-binding protein prevented PKR activation, blocked eIF2α phosphorylation, and restored late viral protein synthesis in cells infected with an E1B-55K or E4orf6-mutant adenovirus. This newly described function of the E1B-55K and …
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Structure and Function Studies of the Orsay Virus δ Protein
… between the Orsay CP-δ fiber and the fibers from reovirus and adenovirus, we propose that CP-δ may interact with the host cellular receptors via its C-terminal head to mediate Orsay entry into worm intestine cells. Therefore, my study suggested that the Orsay δ protein likely has two independent …
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Biochemical characterization of the nucleic acids of some human and animal viruses
… published, although it was known they resembled reovirus in consisting of segmented double-stranded RNA. Such pictures were obtained, and molecular weight estimations made by comparison with dsRNA markers of known MW from a cytoplasmic polyhedrosis virus (CPV) from Heliothis armigera (Harley, …