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Showing 1 to 20 of 36 for “"Renin-Angiotensin System (RAS)"”.

  1. The Brain Renin-Angiotensin System: Biochemical Characterization and Possible Role in Hypertension

    Meyer, Joan MarieUniversity of Illinois at Urbana-Champaign2015

    A renin-angiotensin system (RAS) endogenous to the brain has been proposed on the basis of immunochemical, biochemical and pharmacological evidence. Angiotensin II exerts potent effects in CNS tissues and appears to be involved fluid balance homestasis and blood pressure regulation. The data in …

    uiuc Repository record

  2. The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380

    Chitapi, ItaiDepartment of Molecular and Cell Biology2006

    Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin II, a potent vasoconstrictor. By the same enzymatic mechanism, ACE also …

    cape-town Repository record

  3. Persistent (>6 months) Neuropsychiatric symptoms in a cohort of SARS- CoV-2 PCR positive patients in Cape Town, South Africa

    Van Niekerk, InetteDepartment of Psychiatry and Mental Health2024

    … outcomes with clinical illness severity, systemic inflammation, cardiovascular and renin-angiotensin system (RAS) biomarkers. Methodology: SARS-CoV-2 PCR positive patients were recruited prospectively from Cape Town, South Africa, including hospitalized patients from ancestral, beta and …

    cape-town Repository record

  4. Prorenin, its maturation and the (pro)renin receptor

    L'Huillier, NathalieThe University of Edinburgh2007

    The renin-angiotensin system (RAS) is a key biochemical pathway controlling homeostasis and blood pressure. The initial step of the RAS is carried out by renin to produce angiotensin (Ang) I which is converted to Angll by the angiotensin-converting enzyme (ACE). Renin is synthesized as a pro-enzyme …

    edinburgh Repository record

  5. RADIATION-INDUCED BRAIN INJURY: NOT JUST A MICROGLIA AND HIPPOCAMPUS STORY ANYMORE

    Moore, Elizabeth DianaWake Forest University2013

    … to play a role. However, cognitive studies with renin-angiotensin system (RAS) blockers which increase Ang-(1-7), indicate that microglia and the hippocampus may not be the complete story. Thus, we hypothesized that radiation-induced brain injury may be prevented by i] targeting neuroinflammation …

    wfu Repository record

  6. The Effect of 1,25-Dihydroxy Vitamin D3 on AT1 Cell Receptor Expression in Human Iliac Artery Endothelial Cells (HIAEC)

    Thomas, Jenny2015

    <p>The renin-angiotensin system (RAS) plays an important part in homeostasis through angiotensin IPs role as a vasoconstrictor. Defects in the renin angiotensin system can lead to hypertension, heart attack, and stroke (Weir, 1999). Studies have shown an inverse relationship between Vitamin D3 and …

    columbus-state Repository record

  7. The Angiotensin Receptor (AT₁) Inhibitor, Losartan, Slows Post-Natal Thickening of the Left Ventricle

    Javadi, FaribaSouthwest Texas State University1994

    … study was to test the hypothesis that a local renin angiotensin system (RAS) in the mammalian left ventricle regulates growth of heart tissue in response to pressure-overload. Upon parturition, the mammalian left ventricle (LV) experiences pressure overload to which it responds by rapid growth, …

    texas-state Repository record

  8. Effect of Thyroid Hormones on AT1R MRNA Levels in HEK 293 Cells: Implications for Early-Onset Hypertension in Children Born of Preeclamptic Women

    Eddins, Amanda2015

    … the effect of thyroid hormones, T3 or T4, on angiotensin II type 1 receptor mRNA levels in human embryonic kidney cells (HEK). Maternal preeclampsia is a prediction of higher ambulatory blood pressure (ABP) in the exposed offspring. The mother's blood pressure affects the blood pressure of the …

    columbus-state Repository record

  9. STUDIES ON ANGIOTENSIN-(1-7) AND MITOCHONDRIA: THE ROLE OF AN INTRACELLULAR RENIN-ANGIOTENSIN SYSTEM WITHIN THE KIDNEY

    Wilson, Bryan AnthonyWake Forest University2016

    … failure target a classic circulating hormonal system - the renin-angiotensin System (RAS), and specifically, the ACE-Ang II-AT1 receptor axis. We have focused strategically on investigating novel intracellular pathways by which Ang-(1-7) is generated and degraded since this alternative pathway …

    wfu Repository record

  10. Expression of myofibroblasts and identification of angiotensin receptors in capsular contracture disease around mammary implants

    Touil, LeilaUniversity of Central Lancashire2013

    … in women with implants. There is evidence that Angiotensin-II (Ang-II) is implicated in pathological wound healing and that blockers of Ang-II may prevent fibrosis. Capsules from 12 breasts excised from eight patients undergoing surgery for capsular contracture in the Department of Plastic …

    cent-lancashire Repository record

  11. Myocardial fibrosis and pathological hypertrophy in the rat with aorta-constricted hypertension

    Chang, Kevin ChijengUniversity of Illinois at Urbana-Champaign1992

    … hypertension resulted from the activation of the renin-angiotensin system (RAS) due to renal ischemia. Microscopically, marked interstitial fibrosis with focal necrosis and diffuse perivascular fibrosis in the myocardium were observed. Myocardial fibrosis appears before myocyte necrosis and its …

    uiuc Repository record

  12. Effect of Blood Volume Manipulations and Warm Acclimation on Cortisol Levels in the Antarctic Teleost Trematomus bernacchii

    Hudson, Hilary AnnCreighton University2007

    … and increase gill Na+, K+-ATPase activity. The renin-angiotensin system (RAS) and cortisol have been shown to increase drinking rate and gill Na+, K+-ATPase activity in fish, therefore regulating water and ion balance. Moreover, the RAS has been shown to increase cortisol levels in fish. …

    creighton Repository record

  13. Lesioni degenerative e meccanismi di riparo della superficie oculare: lo pterigio e le deficienze delle cellule staminali del limbo (LSCD). Studio immunoistochimico e tecniche di coltura cellulare

    CORRIAS, MICHELAUniversità degli Studi di Cagliari2014

    … and extracellular matrix remodeling. The Angiotensin converting enzyme (ACE or ACE I) is the major component of the Renin-angiotensin system (RAS) converting the inactive decapeptide Angiotensin I (Ang I) to the active octapeptide Angiotensin II (Ang II). Besides this “classical role”, it …

    cagliari Repository record

  14. Investigating the role of the Renin Angiotensin System in cancer

    Dunn, CheriseDivision of Medical Microbiology2017

    … diseases as possible anti-cancer agents. The renin-angiotensin system (RAS) regulates blood pressure and cardiovascular homeostasis through Angiotensin Converting Enzyme-1 (ACE-1) and its homolog ACE-2. RAS has also been implicated in the progression of various cancers due to the increased …

    cape-town Repository record

  15. New Advances on the Biochemical Pathways in the Reninangiotensin System in Hypertension and their role in Cardiac Structure and Function

    Trask, AaronWake Forest University2009

    … are actually controlled. Because the renin‐angiotensin system (RAS) plays a major contributing role to the pathophysiology of hypertension and heart disease, the studies outlined in this dissertation traverse the complexities of the biochemical pathways within the cardiac …

    wfu Repository record

  16. EFFECTS OF AT1R ANTAGONIST L-158,809 ON NORMAL BRAIN TISSUE INJURY FOLLOWING WHOLE-BRAIN IRRADIATION

    Conner, Kelly R.Wake Forest University2009

    … WBI-induced cognitive deficits. Blockade of the renin-angiotensin system (RAS) is an attractive target since: (1) RAS blockade ameliorates radiation-induced injury to normal lung, kidney, and optic nerve tissue, (2) angiotensin II (Ang II) can act as a pro-inflammatory cytokine via its Ang II …

    wfu Repository record

  17. Revealing the Mechanism Underlying the Beneficial Effects of Angiotensin-Converting Enzyme Inhibitors in a Drosophila Alzheimer’s Disease Model

    Ghalayini, Judy2024

    … Recently, several studies have implicated the renin-angiotensin system (RAS), known to regulate blood pressure, as a possible therapeutic target for AD. RAS inhibiting drugs, including angiotensin-converting enzyme inhibitors (ACE- Is), have been shown to reduce the incidence and progression of …

    toronto-retro Repository record

  18. Regulation of Substrate Metabolism and Renin-Angiotensin System with Dietary and Pharmacological Interventions: Implications for Obesity and Related Disorders

    Da Eira, Daniel Pereira2024

    … diet (KD) on adipose tissue (AT) metabolism and renin-angiotensin system (RAS) function and potential implications for other tissues, including lung, heart and skeletal muscle. In the first study, it was demonstrated that despite increasing fat mass, a KD enhanced energy-dissipating mechanisms in …

    york Repository record

  19. Mechanisms by Which Exercise Training Attenuates Blood Pressure in Animals: Roles of Cytokines, Oxidative Stress, and Glycogen Synthase Kinase-3â

    Agarwal, DeepmalaBiomedical and Veterinary Medical Sciences - Comparative Biomedical Sciences2022

    … PICs and vasoconstrictor components of the renin-angiotensin system (RAS) but also improved anti-inflammatory cytokines (AIC) and vasodilatory axis of the RAS within the brain of SHRs. In the third study, we explored the effects of cessation of exercise (physical detraining) on these …

    lsu-thes Repository record

  20. Angiotensin II receptor blockade and insulin sensitivity in overweight and obese adults with elevated blood pressure

    Marinik, ElainaVirginia Tech2012

    … to insulin resistance in obesity hypertension is renin-angiotensin system (RAS) overactivation. The RAS exhibits vasocontricting and sodium-retaining properties, yet in vivo and in vitro animal experiments suggest impairment of whole-body insulin sensitivity with increased angiotensin II (Ang II) …

    vt Repository record

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