Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Renal transplantation"”.
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The significance of antibody production in human renal transplantation
… is an important part of laboratory testing for transplantation. The conventional technique for screening is complement dependent lymphocytotoxicity. The development and increasing use of the sensitive flow cytometric crossmatch technique has meant that this conventional screening method is often …
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MicroRNAs as biomarkers of injury and drug response in renal transplantation
Renal transplantation remains the optimal treatment for many patients with end stage renal disease. To meet the shortfall of organs available for transplantation, increasingly organs that have both endured and are more susceptible to ischaemia reperfusion injury (IRI), are being utilised for …
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Time-Related Centile Ranges for Quality of Life Outcomes in Renal Transplantation
… quality of life (QoL) following kidney transplantation. QoL is commonly viewed as an important indicator of successful outcomes in chronic disease including kidney transplantation. Despite extensive research documenting the value of QoL, routine measurement of QoL outcomes in clinical …
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Extended electrocardiographic monitoring in patients on chronic haemodialysis and after renal transplantation
… implanted in twenty patients with CKD on the Renal Replacement Programme at Groote Schuur Hospital in Cape Town. Clinical, electrocardiographic and echocardiographic parameters were collected. We reviewed ILR recordings obtained between August 2015 and July 2018 and analysed arrhythmic events …
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Delayed graft function in renal transplantation : aetiology and impact on graft outcome
… optimal therapy for most patients with end stage renal disease is renal transplantation. This form of therapy results in improved quality of life, decreased medical expense, and perhaps a survival advantage for the recipient. Renal transplantation is however a complex form of therapy which may be …
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Evaluation of a novel mitochondria‐targeted anti-oxidant therapy for ischaemia-reperfusion injury in renal transplantation
… major contribution to graft damage during kidney transplantation and increases the risks of primary non-function, delayed graft function and rejection. Oxidative damage to mitochondria is a key early event in IR injury. The aim of this project was to examine the safety and efficacy of the …
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Outcomes of renal transplantation in patients with lupus nephritis: a single centre study in Cape Town
… Although most LN patients are suitable for renal transplantation when they develop end stage renal disease (ESRD), the risk of recurrence of LN post-transplantation can be as high as 30%. Since the outcomes of renal transplantation in ESRD-LN patients has not been adequately studied in South …
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Análise da efetividade do transplante renal na qualidade de vida dos receptores no estado do Rio Grande do Norte
… with the aim of analyzing the effectiveness of renal transplantation on quality of life of kidney recipients in the Rio Grande do Norte State. This is a descriptive study with longitudinal design, panel type with quantitative approach to data analysis. The Quality of Life (QoL) of chronic …
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Evaluation of alterations in cardiovascular structure and function in end-stage renal failure.
Background: Chronic renal dysfunction is associated with myriad alterations in cardiovascular structure and function, resulting in markedly elevated rates of cardiac and vascular morbidity and mortality. Utilising advances in cardiovascular magnetic resonance imaging (CMR), we evaluated the …
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Effects of GH on the IGFs and IGFBPs in children with chronic renal failure and transplantation
… proteins in the serum of children with chronic renal failure (CRF) and transplantation, before and after treatment with recombinant human growth hormone (rhGH). IGF-IGFBP complexes in pooled serum from prepubertal and pubertal children of both sexes with CRF and renal transplantation, before and …
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A retrospective review with prospective follow up of renal function, blood pressure and proteinuria post living donor nephrectomy at Groote Schuur Hospital, Cape Town South Africa
Introduction: Renal transplantation is the treatment of choice for patients with end stage renal disease [ESRD]. An increased risk of ESRD has been demonstrated when comparing donors to age matched healthy non-donors. There are no outcome data in Africa on long term donor renal function or …
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Renal Transplant Survey: how standardised is a standard kidney transplant?
… discover if there are international standards in renal transplantation. Method: A questionnaire was created using an online survey tool (Qualtrics ®), and distributed to a list of email addresses supplied by the unit's senior transplant surgeon. A literature review was performed on the questions …
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Characteristics of Donor-Specific anti-HLA Antibodies (DSA) Impacting different Renal Allograft Outcomes
AMR is the major complication of renal transplantation that significantly affects the allograft survival. Complement fixation of Donor specific anti-HLA antibodies is the hallmark of AMR. Different methods have been developed to detect harmful DSAs. However, not all DSAs have the same detrimental …
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Investigating the role of HLA class I derived peptide in alloreactivity.
… alloresponses, within the context of clinical transplantation.This research describes the creation of a database of HLA class I derived peptides predicted to bind to HLA-A*02 molecules, and then utilises this database to identify HLA class I derived peptides which are bound by the HLA-A*02 …
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Investigating the cerebral/pulmonary axis following traumatic brain injury in a preclinical model
… following other distant organ injury such as renal ischemia-reperfusion injury (IRI) and renal transplantation were assessed. Significant pulmonary interstitial neutrophil accumulation was seen following both models and was associated with significant pulmonary haemorrhage. Inducing HSP70 …
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Effects of exercise, renal disease, and digoxin on skeletal muscle Na+,K+-ATPase and related effects on plasma K+ and muscle performance
… skeletal muscle Na+,K+-ATPase – acute exercise, renal disease and digoxin. The related effects on plasma [K+] during exercise and on muscle performance were also examined. This thesis firstly investigated the acute effects of brief intense exercise on muscle Na+,K+-ATPase content and maximal …
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Kidney Compatibility Score Generation for a Donor - Recipient pair using Fuzzy Logic
… is one of the major problems encountered in Renal Transplantation. Kidney Paired Donation is a barter system where the pairs exchange the donor organs to overcome the disadvantage of incompatibility. Identification of such pairs requires a Kidney Transplant Surgeon to evaluate the …
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Examining the regional physiology of the transplant kidney during normothermic machine perfusion.
… unavoidable consequence of deceased-donor kidney transplantation that has a profound effect upon both immediate and long-term graft function. Disruption to microvascular perfusion (MVP) and tissue oxygenation (PtO2) are central to the development of IRI, but detailed regional pathophysiology …
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