Global ETD Search
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Showing 1 to 2 of 2 for “"Renal drug transporters"”.
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Renal Drug Transporters – Clinical Significance and Role in Drug-Drug Interactions
Drug transporters play an important role in drug disposition and can be major determinants of drug pharmacokinetics, pharmacodynamics and toxicity. In contrast to drug metabolizing enzymes, which mainly concentrate in the liver and small intestine, drug transporters are expressed ubiquitously …
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Regulation of Human Renal Drug Transporters by Inflammatory Cytokines and Pregnancy-related Hormones in Primary Proximal Tubular Epithelial Cells
Systemic inflammation and pregnancy both alter drug pharmacokinetics by changing physiology and modulating drug-metabolizing enzymes and transporters in eliminating organs. Regulation of hepatic enzymes in these states is relatively well described. However, the magnitude, direction, and mechanisms …