Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Renal damage"”.
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Factors Regulating the Intrarenal Renin-Angiotensin System and Renal Damage During Aging
… not entirely known. The activation of the intrarenal RAS and onset of renal dysfunction occurs over the same time span as many of the features of the MetS, while the systemic RAS declines. This suggests that suppression of the intrarenal RAS may be partly responsible for the salutary effects of …
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Urinary tract infection in small children: aspects of bacteriology, vesicoureteral reflux and renal damage
… of UTI, long-term consequences associated with renal damage may occur. Research questions: What is the relation between UTI, VUR and renal damage? How has bacterial resistance to oral antimicrobials changed over time? What is the significance of a low bacterial count? How does renal damage …
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Renal Cannabinoid Receptor Expression and Function: Their Role in Obesity and Diabetes
… clearly established independent risk factors for renal disease. Therapeutic targets have been investigated for their role in treating obesity and diabetic associated renal damage. The endocannabinoid system is an important endogenous lipid signalling system known to mediate glucose and lipid …
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Characterization of severe and complicated hypertension in Mozambican adults
… been described. However, data on target-organ damage and associated clinical conditions is lacking. We therefore aimed at characterising the clinical profile of patients with severe hypertension, describing the pattern of target organ damage and determining the outcomes at 6-month follow-up. …
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Ruolo delle cellule staminali mesenchimali in modelli cellulari e animali di nefropatia
… cells (MSC) may be of value in regeneration of renal tissue after damage, however lack of biological knowledge and variability of results in animal models limit their utilization. Methods. We studied the effects of MSC on podocytes ‘in vitro’ and ‘in vivo’ utilizing adriamycin (ADR) as a model …
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Biochemische und funktionelle Charakterisierung einer gerichteten Gendeletion (Knockout) von Fetuin-A in Mäusen
… in arteries and soft tissues, as seen in chronic renal failure. However, recent studies show that proteins also low molecular weight compounds act as inhibitiors of unwanted mineral precipitation. The serum protein fetuin-A/a2-HS glycoprotein (Ahsg) can transiently inhibit the calcium phosphate …
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Valutazione del rapporto urinario proteine totali/creatinina e albumina/creatinina in cani affetti da iperadrenocorticismo e da diabete mellito
… and effective therapy in the early phase of renal damage. Conversely, in dogs, these relationships were not fully investigated, even though hypertension has been associated with many diseases (Bodey and Michell, 1996). In a previous study, 20% of diabetic dogs were found proteinuric based on …
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Consequences and Prevention of Elevated Circulating Tyrosine during Nitisinone Therapy in Alkaptonuria.
… to debilitating early onset osteoarthropathy, renal damage and aortic valve disease. As a multisystem disorder, AKU results in progressive and chronic pain and severe morbidity. Most management approaches for AKU are palliative and rely largely on analgesia and arthroplasty. Several therapeutic …
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The Omental Fat Band as an Immunomodulatory Microenvironment for Ovarian Cancer
… reported side effects, such as hepatic and renal damage, cardiotoxicity and death. Targeted IL-12 delivery to the OFB resulted in delayed disease development, although not protection from subsequent challenge. This was also associated with a reduction tumor-associated macrophages (TAMs) and …
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An analysis of the mechanisms of acute kidney injury and novel biomarkers
… is that cystatin C has the potential to indicate damage to glomerular filtration while KIM-1 and NGAL have the ability to indicate damage to the proximal tubule. Along with the ability to provide information as to the specific site of renal injury, the levels of cystatin C, KIM-1, and NGAL …
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Effetti dell'acido urico sulle cellule glomerulari mesangiali: meccanismi intracellulari di trasduzione del segnale e possibili implicazioni nella progressione del danno renale e nella sindrome infiammatoria in corso di nefropatie croniche
Uric acid is a major inducer of inflammation in renal interstitium and may play a role in the progression of renal damage in hyperuricemic subjects with primary nephropathies, renal vascular disease, and essential hypertension. At the same time, UA also acts as a water-soluble scavenger of reactive …
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Estimation of Kidney injury molecule-1 and microalbuminuria levels in hypertensive patients at the University Teaching Hospital,Lusaka
… specific intervention that may avert permanent renal damage and progression of CKD to End Stage renal Disease (ESRD) can also be delayed with early diagnosis and intervention. Hypertension is a major public health problem and the most important cause of renal failure and dialysis all over the …
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Estimation of Kidney injury molecule-1 and microalbuminuria levels in hypertensive patients at the University Teaching Hospital,Lusaka
… specific intervention that may avert permanent renal damage and progression of CKD to End Stage renal Disease (ESRD) can also be delayed with early diagnosis and intervention. Hypertension is a major public health problem and the most important cause of renal failure and dialysis all over the …
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Studies on the Epidemiology and Outcome of Primary Systemic Vasculitis
… to be 97%. (II) The extent of irreversible organ damage, on the date of p.p., was measured using the Vasculitis Damage Index (VDI), for all the 86 patients from Paper I. Organ damage was very common in our patients, the medium VDI score was 3 and only 9% had not been assigned any item of damage. …
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Establishing a Murine Model of Malaria-Associated Acute Kidney Injury and Demonstrating the Contribution of Extrinsic Apoptosis to Tubular Necrosis
… conjunction with in vitro assays utilizing human renal cells and Plasmodium falciparum-infected red blood cells (PfiRBCs), to identify molecular pathways of tubular epithelial cell death in the context of MAKI. Lateral nephrectomies were performed on wild-type mice prior to infection with …
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Characterization of Novel CB2 Agonist SMM-295 and Its Effects in Ischemia/Reperfusion Injury
… AKI include tubular cell death and a decrease in renal perfusion which leads to decreases in renal function following injury. For 20 years the pathophysiology of AKI has been well established. However, therapies for AKI have shown minimal to no success clinically. The work here describes our …
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Langfristige Entwicklung Zytostatika-induzierter Nierenfunktionsstörungen bei pädiatrisch-onkologischen Patienten
… 55.7% of the patients show a normal renal function. Slight damages seem to improve rather than serious damages that show a tendency to persistence. In the group of the children treated for leukemia persistent nephrotoxicity is rare, despite of the treatment with high-dose …
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Energetic and dynamic characterization of the IgA1:FcαRI interaction reveals long-range conformational changes in IgA1 upon receptor binding
… complexes in the kidney, resulting in end-stage renal failure in 20-30% of IgAN patients. The mechanism of FcαRI's involvement in IgAN, however, is unclear. Naturally-occurring circulating immune complexes consisting of IgA-bound FcαRI have been implicated in IgAN, although soluble FcαRI levels …
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Preeclampsia: The Roles of Acute Inflammation and Intrauterine Stress
… PE is characterized by hypertension and renal damage reflected by proteinuria and has significant morbidity to both mother and fetus. Maternal symptoms range from headaches, nausea, edema, to visual changes, but once maternal symptoms present, damage to the fetus has begun. Mothers who …
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Exploring the impact of maternal obesity on offspring renal morphology and later life health
… exposed to maternal obesity. Alterations in renal morphology in early life have been linked to hypertension and renal disease in adulthood in both epidemiological and animal studies. Therefore, a second aim of this thesis was to assess blood pressure, renal function and markers of renal …