Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Renal cancer"”.
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Evaluating metabolism in human renal cancer using novel surgical models
… the pivotal roles of metabolic reprogramming in cancers. Indeed, this evidence has cumulated in the establishment of dysregulated metabolism as a contemporary hallmark of cancer. Metabolomics has been vital to define the metabolic landscape of cancers. This technique allows the simultaneous …
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Potential of metabolic MRI to address unmet clinical needs in localised renal cancer.
… of early-stage (localised and locallyadvanced) renal cancer. Renal cancer is the deadliest urological malignancy with a widening gap between incidence and mortality, which highlights the need to review the current guidelines. In particular, early-stage renal cancer is to be looked into as it is …
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Inkstų vėžys Lietuvoje: sergamumo ir mirtingumo pokyčių analizė /
The aim of the study: To review epidemiology of renal cancer in Lithuania during the period 1998 – 2012. Tasks of the study: 1. To estimate the changes of renal cancer incidence in Lithuania in 1998 – 2012. 2. To estimate the changes of renal cancer incidence in Lithuania depending on stage of the …
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Small Molecule Inhibitors of MAPK and PI3K Pathways Enhance MDA-7 Lethality in Renal Cell Carcinoma
Renal cell carcinoma accounted for an estimated 57,760 new cases and estimated 12,980 deaths in the United States in 2009. Current treatment options for systemic renal cell carcinoma yield markedly low response percentages; however, recent cytokine therapy experiments have produced promising …
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Semi-Synthesis of Melodinine, Taberyunine, and Melosuavine Bis-Indole Alkaloids Through Chemical and Biological Methods
… study of the bis-indole framework against colon cancer and melanoma cell lines. Alkaloid aryl trifluoroborates were synthesized to increase nucleophilicity of arenes for unfavored alpha-arylations of tertiary amines on route to melosuavine bis-indole alkaloids. Overall, nine new bis-indole …
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Role of PBRM1 in regulation of the HIF pathway
… was recently found to be mutated in different cancer types such as pancreatic, breast, and renal. Interestingly, PBRM1 and VHL are the most frequently mutated genes in clear cell Renal Cell Carcinoma (ccRCC). Mutations or loss of VHL leads to upregulation of both HIF1α and HIF2α. However, …
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Risk of Subsequent Neoplasms During the Fifth and Sixth Decades of Life in the Childhood Cancer Survivor Study Cohort
Childhood cancer survivors are at increased risk for subsequent neoplasms (SNs), but the incidence beyond age 40 and associations with therapeutic exposures have not been well- described. Among 14,364 childhood cancer survivors diagnosed between 1970 and 1986, 3,171 had an attained age ≥40 years at …
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Identification and characterisation of HNF1B as a pro-tumorigenic lineage factor in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer. ccRCCs exhibit considerable genetic intratumour heterogeneity, and current therapies lack long-term efficacy due to drug resistance. Novel therapeutic targets are thus required to combat this disease. The most …
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The Relationship Between Uncertainty in Illness and Anxiety in Patients With Cancer
Anxiety is a common problem for patients with cancer. Anxiety may have a negative impact on decision making and overall emotional well being of patients and may be related to the uncertainties faced by people with cancer. This study examined the relationship between uncertainty in illness and …
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Mitochondrial metabolism in cancer transformation and progression
Cancer cells undergo a multifaceted rewiring of cellular metabolism to support their biosynthetic needs. Although the major determinants of this metabolic transformation have been elucidated, their broad biological implications and clinical relevance are unclear. In this study, I systematically …
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Novel multi-parametric, multi-modality imaging for the assessment of tumour biology in renal cell carcinoma
Renal cancer (RCC) is the 7th commonest cancer in the UK and clinically, morphologically, genetically and metabolically heterogeneous. Inaccurate patient stratification limits the treatment of RCC. This thesis investigates imaging techniques and image-analysis methods ranging from easily …
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Compensatory renal hypertrophy, mitochondria and redox status
<p>A reduction in functional renal mass occurs in humans during aging and severe kidney damage from diseases, injuries, infections and congenital conditions and after nephrectomy. Nephrectomy, or surgical removal of a kidney or a section of a kidney, is performed for treatment of unilateral …
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Mechanisms of Synthetic Lethality in Renal Cell Carcinoma
Clear cell renal cell carcinoma (ccRCC), the most common subtype of kidney cancer, is characterised by biallelic inactivation of the von Hippel-Lindau (*VHL*) tumour suppressor gene, and inherited loss-of-heterozygosity of *VHL* underlies the eponymous hereditary cancer syndrome. The *VHL* protein …
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The role of sphingosine kinases and dihydroceramide desaturase in regulating senescence in prostate cancer cells
… (S1P). SKs have been widely implicated in human cancers and inflammation. This has been demonstrated to be a consequence of the actions of S1P, which acts as a ligand at five G protein-coupled receptors - termed S1P1-5. S1P is also an intracellular effector which binds to proteins such as HDAC1/2 …
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Characterising DNA methylation in tissue and liquid samples from patients with renal tumours
The incidence of renal cell carcinoma (RCC) and small renal masses (SRMs), defined as <4cm in diameter, is increasing dramatically. SRMs encompass a variety of potential diagnoses, including benign and malignant tumours, the most common of which is clear cell RCC (ccRCC). Current methods are unable …
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Axl RTK and microRNAs in urogenital cancers
… kinase (RTK) and microRNAs in clear cell renal cell carcinoma (ccRCC) and in prostate cancer (PCa). Paper I focuses on differentially expressed microRNAs in ccRCC. We used bioinformatics methods to identify candidate microRNAs in a publically available cohort of ccRCC, which were measured …
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The generation of a human cell line to elucidate the role of Fumarate Hydratase loss in cancer
… metabolism is an established hallmark of cancer, which enables cancer cells to survive, proliferate, and metastasize even under harsh environmental conditions. These cancer-associated metabolic changes can affect several pathways one of which is mitochondrial metabolism. The suppression of …
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Trichloroacetimidates As Outstanding Electrophiles for the Carbon-nitrogen, Carbon-oxygen and Carbon-carbon Bonds Formation and Synthetic Studies of Protein Phosphatase-5 (pp5) Small Molecule Inhibitors
… overactivation of PP5 has been linked to the renal cancer and a great need of therapeutic treatment development is necessary. Two previously identified potent inhibitors were synthesized and coupled with biotin and BODIPY dye for pulldown assays and binding data respectively. With the help of …
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Molecular genetic investigations of renal cell carcinoma predisposition
Renal Cell Carcinomas (RCC) are a diverse group of histologically and genetically distinct renal neoplasms accounting for 2.4% of all cancers worldwide. While a majority of RCC cases are sporadic in nature, a proportion are due to genetic predisposition caused by syndromic and non-syndromic …
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Genetic basis of inherited kidney and related tumours
Renal cell carcinoma (RCC) represents the 6th most commonly diagnosed cancer in males and the 10th most commonly diagnosed cancer in females, worldwide, with incidence rates rising. It has been estimated that 3-5% of RCC is inherited. The aim of this thesis was to improve the understanding of the …
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