Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"Renal Excretion"”.
-
Ionic processes in urine: a study of factors which may affect the renal excretion of inorganic phosphate
… to the problem of the mode of regulation of the renal excretion of inorganic phosphate. Part one presents new data concerning the hypothesis of secretion of inorganic phosphate in the dog kidney, and as such is clearly relevant to the problem cited above. Part two arose from the earlier …
-
The effects of lipid-based nutrient supplements containing vitamins and minerals on renal excretion of electrolyte and tenofovir concentrations in blood among Zambian HIV/AIDS patients
… Supplements Containing Vitamins and Minerals on Renal Excretion of Electrolytes and Tenofovir Concentrations in Blood among Zambian HIV/AIDS Patients by Derick Munkombwe Background: Advanced HIV-infection combined with under-nutrition and anti-retroviral therapy (ART) places patients at high risk …
-
Recombinant Hemoglobin Variants: Structure-Function Analysis and Oxygen Therapeutic Design
… exhibited an increased vascular lifetime and no renal excretion. Furthermore, a dose dependent increase in vascular lifetime was observed suggesting that the protein clearance mechanism is saturatable. These circularly permuted variants represent the first recombinantly designed polymerized …
-
Urinary Excretion of (1-3)-Beta-D-Glucans.
… glucans; the present studies investigated the renal excretion of (1→3)-β-D-glucans following intravenous and oral administration. Three fluorescently-labeled glucans were administered to adult male rats in the presence or absence of toxic challenge. Urine specimens were collected and analyzed …
-
Sympathetic nervous system in the development of mild DOCA-salt hypertension
… to maintain volume homeostasis by altering the renal excretion of salt and water in response to changes in arterial pressure. But there is also compelling evidence for a role of the central nervous system in long-term regulation of arterial pressure, primarily by modulating sympathetic nerve …
-
Aspects of retransfusion of shed blood in cardiac surgery
… function of various organs is an ongoing debate. Renal dysfunction after cardiac surgery is a well known complication. Monitoring of renal function is important, both for the guidance of renal intervention and for the prediction of outcome. Cystatin C has been suggested as a more sensitive marker …
-
Chemoligand therapy for metastatic castration-resistant prostate cancer
… to its low nonspecific processes and rapid renal excretion. Without exceeding a specificity threshold dosage of 0.5 mg/kg qw x3 (empirically determined in PSMA<sup>-</sup> PC-3 tumors), the chemoligand more than doubled the median survival (<em>P </em>= 0.04) of male mice bearing …
-
Characterization of a human renal organic anion transporter
The renal excretion of organic anions, including a variety of endogenous substances, xenobiotics and their metabolites, involves an organic anion transport system with multiple specificity. The well characterized basolateral uptake step of this process involves the organic anion transporter 1 …
-
COMBINATORIAL MOLECULAR PHARMACOLOGICAL AND PRECLINICAL STUDIES OF AN EPIGENETIC ANTICANCER DRUG, 3-DEAZANEPLANOCIN A, IN RATS
… (SD) rats. DZNep caused nephrotoxicity and renal atrophy in rats in a dose-dependent manner but had no apparent effect on the hematological system of rats. A sensitive and reliable liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed for the …
-
The Relationship of Discrete Amino Acid Regions to the Biochemical Properties of Human Phenol Sulfotransferases (SULTs)
… effects such as increased water solubility and renal excretion, decreased activity, activation of certain agents, and formation of unstable esters that react with DNA to form adducts. The most studied form of the sulfotransferase (STILT) enzymes in humans is SULT1 Al. Allozymes (expressed …
-
Structually diverse Cu-64-labeled RGD peptide conjugates for PET imaging of αvβ3 expression
… <italic>in vivo</italic> biodistribution and excretion were studied in normal rats. Integrin α<sub>v</sub>β<sub>3</sub> is upregulated in tumor vasculature, osteoclasts, and areas of collateral circulation following ischemic injury. A series of structurally diverse bifunctional RGD: …
-
Pharmacokinetic and Pharmacodynamic Studies of a Novel Spectinamide Series of Antituberculosis Agents
… urine (0.46 to 1.0). Spectinamides exhibited a renal excretion ratio greater than one indicating filtration and active secretion as the net renal elimination process. In the uptake experiments, the spectinamides exhibited 3‑4 times higher uptake into murine macrophages compared to streptomycin …
-
Quantitative Studien zu Vorkommen und metabolischem Transit alimentärer Maillard-Reaktions-Produkte
… aus dem Körper von Interesse. Anhand der renalen Exkretion definierter Lysinderivate in Abhängigkeit von der nahrungsbedingten Zufuhr sollten Aussagen zu deren metabolischem Transit getroffen werden. Es wurde eine Ernährungsstudie durchgeführt, in der die Probanden zunächst auf MRP-haltige …