Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"Renal Cell Carcinoma (RCC)"”.
-
Outcomes of Genetic Testing In A Genitourinary Genetics Clinic
… seen for genetic evaluation related to either renal cell carcinoma (RCC) or prostate cancer. Among patients seen for RCC-related evaluation (N=107), meeting published clinical criteria for a hereditary RCC syndrome significantly predicted positive genetic testing (<em>P</em></p>
-
Molecular cytogenetics and genetic characterisation of chromosomal rearrangements
… 6.0 arrays) to identify copy number changes in renal cell carcinoma (RCC) primary tumours (n=81) and cell lines (n=23). Copy number changes most frequently involved large segments (>10Mb) and loss of 3p and gain of 5q were the most common copy number changes. A comparison of copy number changes …
-
Investigation of the genetic basis of multiple primary renal tumours
… for an underlying predisposition to cancer. Renal cell carcinoma (RCC) occurs in several hereditary cancer disorders syndromes and RCC-related MPT comprise individuals with multiple primary renal tumours (MPRT) and those with RCC plus a non-renal tumour (MPT:RCC+X). Excluding rare syndromic …
-
Consequences of Pathogenic Mitochondrial DNA Mutations in Cancer Progression
… of nuclear isogenic transmitochondrial cancer cell lines with defined pathogenic mutations, and secondly, by the establishment of a collection of patient tumor xenograft models with varied mtDNA status. Chapter two details the development of a new cytoplasmic hybrid (cybrid) generation method …
-
A study of succinate dehydrogenase deficient tumourigenesis: From functional assessment of variant pathogenicity to the discovery of new disease biomarkers
… gastrointestinal stromal tumours (GIST) (2), renal cell carcinoma (RCC) (3) and pituitary adenomas (4). Pathogenic variants in each of the four genes (SDHx) encoding the four sub-components of this complex (SDHA/B/C/D) have been associated with tumourigenesis. Germline pathogenic variants in …
-
Advanced analytical strategies to determine biomedical parameters for medical diagnostics, drug delivery, and therapy
… developed micro-pH sensor, 2) quantification of renal cell carcinoma (RCC) biomarkers by high-performance liquid chromatography - tandem mass spectrometry (HPLC-MS/MS), and 3) nuclear magnetic resonance (NMR) studies of porous wall hollow glass microspheres (PWHGMs) that have the potential to be …
-
First-order statistical speckle models improve robustness and reproducibility of contrast-enhanced ultrasound perfusion estimates
… a rapid patient-derived xenograft (PDX) model of renal cell carcinoma (RCC) in the chorioallantoic membrane (CAM) of chicken embryos. The ultimate goal of the PDX model is to screen RCC patients for de novo sunitinib resistance. The analysis of the first-order speckle statistics of …
-
Quantification Of Vascular Parametric Indices Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging
… the vascular changes in DCE-MRI, a pre-clinical renal cell carcinoma (RCC) tumor model was used to demonstrate the ability of DCE-MRI to quantify the vascular changes induced by various doses of sunitinib in tumor-bearing kidneys and normal contralateral kidneys. Usually, only the first minute of …
-
Prognostic significance of preoperative neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with non-metastatic clear cell renal cell carcinoma
… recurrence in patients with non-metastatic clear cell renal cell carcinoma (RCC). Material & Methods: We retrospectively reviewed the medical records of 341 patients (232 men and 109 women, mean age of 54.9 years) with non-metastatic clear cell RCC who underwent radical or partial nephrectomy …
-
Correlation of Caveolin-1 Expression on Tissue Microarray with Prognosis in Renal Cell Carcinoma
… implicated in the regulation of intracellular signaling pathways. Altered caveolin-1 expression is thought to be involved in several important human diseases including cancer. However, the role of caveolin-1 in renal cell carcinoma (RCC) is still uncertain. Some reports have suggested …
-
A multifaceted study of the receptor tyrosine kinase Axl with focus on Renal Cell Carcinoma
… in several human malignancies, with focus on renal cell carcinoma (RCC). At first, our main interest concerned the intracellular Axl interactor named Tensin2 (Tns2) and its family member Tensin3 (Tns3). Tns2 and Tns3 are structural focal adhesion proteins, linking the extracellular matrix and …
-
Relato de caso: manejo anestésico de nefrectomia com trombectomia cavoatrial sob circulação extracorpórea
Introduction: Clear cell carcinoma (CCC) is the most prevalent histological subtype of renal cell carcinoma (RCC), accounting for 70–80% of cases. A characteristic feature of RCC is its propensity for venous invasion, with tumor thrombus formation in the renal vein and extension into the inferior …
-
The role of stem cells and WNT signalling pathway in renal cell carcinoma
Introduction: Renal cell carcinoma (RCC) accounts for 87% of all kidney cancers. Despite advances in diagnostic techniques and management, renal cell carcinoma remains a lethal tumour accounting for substantial mortality and morbidity. The poor prognosis arises from metastasis, chemoradiation …
-
Characterising DNA methylation in tissue and liquid samples from patients with renal tumours
The incidence of renal cell carcinoma (RCC) and small renal masses (SRMs), defined as <4cm in diameter, is increasing dramatically. SRMs encompass a variety of potential diagnoses, including benign and malignant tumours, the most common of which is clear cell RCC (ccRCC). Current methods are unable …
-
A Study Of The Molecular Genetics Of Renal Cell Carcinoma In Man
… isoforms 165 and 189 mRNA in patients with renal cell carcinoma (RCC). Patients with RCC underwent radical nephrectomy at Derriford Hospital, Plymouth. Tumour as well as matched normal tissue from the kidney was harvested, snap frozen and stored in liquid nitrogen, and used to quantitate …
-
Prognostic Significance of Chromosome 9p Deletion in Clear Cell Renal Cell Carcinoma
… role of chromosomal copy number aberration in renal cell carcinoma (RCC) has been explored in several studies. Chromosome 9p deletion was reported as an independent prognostic factor in clear cell subtype (ccRCC). The findings from these studies initially appeared promising however they were of …
-
Genetic basis of inherited kidney and related tumours
Renal cell carcinoma (RCC) represents the 6th most commonly diagnosed cancer in males and the 10th most commonly diagnosed cancer in females, worldwide, with incidence rates rising. It has been estimated that 3-5% of RCC is inherited. The aim of this thesis was to improve the understanding of the …
-
Potential of metabolic MRI to address unmet clinical needs in localised renal cancer.
… of early-stage (localised and locallyadvanced) renal cancer. Renal cancer is the deadliest urological malignancy with a widening gap between incidence and mortality, which highlights the need to review the current guidelines. In particular, early-stage renal cancer is to be looked into as it is …
-
Modeling and Optimization of Individualized Liver Contrast-enhanced CT Imaging
… benign tumors, cancers (especially hepatocellular carcinoma), and metastasis development from non-liver primary cancers. While there are other modalities which can be used to image liver, contrast-enhanced CT imaging is the most commonly used technique to screen for these abnormalities in …
-
Hypoxia regulated pathways in urological malignancies
… are constitutively expressed in many clear-cell RCCs due to loss of pVHL tumour<br/>suppressor function within the tumour. In vitro, HIF-1 and HIF-2 regulate a differential set of<br/>target genes, although their expression in primary ccRCC clinical samples and their effects on<br/>patient …
Page 1 of 2