Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 453 for “"Remodelling"”.
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MOLECULAR MECHANISMS REGULATING SPINE REMODELLING
N-Cadherin plays an important role during dendrite arborisation, axon guidance and synaptogenesys. In particular, at synaptic sites, it is required for activity-dependent synaptic plasticity and dendritic spine remodeling. Recent studies have shown that N-Cadherin can be cleaved by the …
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Vascular remodelling in malignant hypertension
… However the principal pathology is vascular remodelling of resistance vessels, termed fibrinoid necrosis, which causes ischaemic end-organ injury. Cardiovascular disease is the leading cause of mortality in western society and typically the consequence of atheromatous and/or hypertensive …
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Remodelling Surface Site Interaction Points
The Surface Site Interaction Point (SSIP) model describes the non-covalent interaction properties of molecules by abstracting a discrete number of points on the van der Waals surface of molecules. Each point is assigned a value based on empirical interaction scales and the calculated Molecular …
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Oncogene-induced remodelling of cellular networks
Biochemical networks maintain cellular homeostasis by processing information from the intra- and extra-cellular environments and coordinating appropriate responses to stimuli and stressors. During carcinogenesis, cells accrue genetic alterations that rewire signalling pathways, eventually leading …
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Biomechanics of Cardiac Remodelling in Heart Failure
… body. HF is the result of maladaptive cardiac remodelling that alters myocardial structure and ventricular function. Current HF treatments were developed targeting patients with systolic dysfunction, but these treatments are ineffective in treating HF patients with diastolic dysfunction. In …
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Biomarkers of ventricular remodelling in African hypertensives.
… effects of long standing hypertension on cardiac remodelling which ultimately lead to systolic and diastolic dysfunctions as this affects the prognosis, management and treatment modalities of hypertension. We studied 210 subjects who were subdivided into three groups after echocardiography: those …
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Lesion-induced Synaptic Remodelling In The Rat Red Nucleus
… as a model for the study of synaptic remodelling following specific deafferentation. The normal neonatal and adult afferent projections from the deep cerebellar nuclei and the sensorimotor cortex were studied using anterograde and retrograde transport of horseradish peroxidase …
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Hypertrophic scar therapy : pressure-induced remodelling and its determinents
… or durations of pressure required to induce remodelling. Correlation of these parameters is necessary to define guidelines to optimise pressure therapy. Measurement of pressure applied to hypertrophic scars by garments with elastic properties was achieved using a monitoring system based on a …
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The role of anaphylatoxins in asthma and airway remodelling
… mucosa. C3a and C5a-stimulated production of remodelling mediators and the biological function of the anaphylatoxins on the structural cells was also assessed. -- Immunohistochemical analysis revealed elevated expression/deposition of C3 and C5 components in the epithelium, airway smooth …
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The Nucleosome Remodelling & Deacetylase complex: Genome folding & transcriptional regulation
… of NuRD linking together it's chromatin remodelling and histone deacetylase subcomplexes. Comparing steady state wild-type (WT) and Mbd3- knock out (KO) conditions as well as a timecourse of reintroduction of Mbd3 to Mbd3-KO cells I will firstly identify features of chromatin folding …
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PIEZO1 Channel-Mediated Mechanotransduction as a Driver of Cardiac Remodelling
… the mechanism linking mechanical cues to adverse remodelling remains unclear. Fibroblasts are major effector cells of fibrotic remodelling. Still, the precise mechanism by which fibroblasts decode biomechanical cues in settings such as pressure overload has not been fully resolved. This thesis …
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Pathophysiological role of aldosterone in cardiac remodelling after myocardial infarction
… HF and premature death. This process is termed remodelling. It is now understood that a complex series of mechanical, genetic and neurohormonal factors, including the mineralocorticoid hormone aldosterone, are implicated in its pathogenesis. Aldosterone antagonism reduces cardiovascular …
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Investigating lymphatic vascular remodelling during postnatal mouse mammary gland morphogenesis.
… epithelium and blood vasculature undergo dynamic remodelling events in response to hormonal signals and functional demands during postnatal mouse mammary gland morphogenesis (Djonov et al., 2001; Matsumoto et al., 1992; Richert et al., 2000; Watson and Khaled, 2008). The aims of this project were: …
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Growth, modelling and remodelling of cardiac tissue: a multiphase approach
… disease as linked to cardiomyocyte growth and remodelling of the microstructure, a continuum bi-phasic model applicable to cardiac tissue is formulated based on the theory of porous media (TPM). This makes it possible to account for interactions and contributions of multiple phases of …
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Computational biomechanics in the remodelling rat heart post myocardial infarction
Cardiovascular diseases account for one third of all deaths worldwide, more than 33% of which are related to ischemic heart disease, including myocardial infarction (MI). This thesis seeks to provide insight and understanding of mechanisms during different stages of MI by utilizing finite element …
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Computational simulation of bone remodelling post reverse total shoulder arthroplasty
… and trabeculae architecture - a process termed remodelling. Implanted orthopaedic devices can significantly alter the loading on the surrounding bone. In addition, these devices rely on bone ingrowth to ensure secure implant fixation. In this project, a computational model that accounts for bone …
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Nitric oxide induces chromatin remodelling in the developing central nervous system
… of gene regulation by influencing chromatin remodelling. My data also show that NO accumulates within the nucleus of cortical neurons upon BDNF stimulation, thereby inducing Snitrosylation of a wide array of nuclear proteins. S-nitrosylation of histone deacetylase 2 (HDAC2) decreases its …
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Dual Roles for NBR1 in Bone Remodelling and Autophagosomal Protein Degradation
NBRl (Neighbour of BRCAJJ is a ubiquitously expressed scaffold protein that mediates intracellular functions through protein-protein interactions. The C-terminal UBA domain of Nbrl binds mono- and polyubiquitinated chains whilst the N-terminal PB1 domain interacts with the structurally similar …
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