Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Remodeling activity"”.
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The Mi-2 Homolog Mit1 Actively Positions Nucleosomes Within Heterochromatin to Suppress Transcription
… heterochromatin. Mit1 is the putative chromatin remodeling subunit of the fission yeast Snf2/HDAC repressor complex (SHREC) and is known to repress transcription at regions of heterochromatin. However, how Mit1 modifies chromatin to silence transcription is largely unknown. Here we report that …
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Identification and Characterization of Hells-CDCA7, a Nucleosome Remodeling Complex Required for Mitotic Chromosome Structure
… throughout the cell cycle, its catalytic activity is greatly enhanced in mitosis where it can act on nucleosomal substrates. In contrast, condensin is specifically recruited to M phase chromatin and prefers a non-nucleosomal substrate. I show that nearly all proteins involved in nucleosome …
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"Don't Destroy Our Neighborhood": Neighborhood Imaginaries and the Politics of Upzoning / Displacement through Development: Spatial and Temporal Dynamics of Residential Eviction and Capital Investment
… the relationship between building permit activity and residential evictions in Seattle and Tacoma, pointing to a robust pattern in which evictions immediately precede demolition and remodeling activity. Additionally, permit activity in the surrounding neighborhood is associated with an …
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Detecting and Modifying Chromatin Organization in the Budding Yeast Genome with Synthetic Proteins
… mechanisms underlying targeted chromatin remodeling at a subset of genome loci by the chromatin remodeler Isw2. Next, a protocol for efficiently detecting nucleosome positions is described, including its application to yeast deficient in chromatin remodeling activity. In chapter five, I …
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Assessment of material properties in bone surrounding microdamage
… treatment. They suppress bone resorption/remodeling, preventing bone loss. However, BPs also suppress the beneficial bone remodeling that replaces microscopically damaged bone that occurs from normal mechanical wear-and-tear or fatigue, leading to impaired tissue material properties and in …
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Effects of Marathon Training on Male and Female Femoral Stress Fracture Risk
… muscle activation patterns that influence bone remodeling may cause this observed difference in stress fracture occurrence. The goal of this thesis was to develop a finite element model of the femur during marathon training, then determine if marathon training affected bone properties of male …
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The Effects of DEAD-box Helicase Activity on Biomolecular Condensate Structure and Dynamics
… their enzyme-dependent RNA interactions and RNA remodeling activity. First, we show how a DEAD-box helicase’s nucleotide dependent RNA-binding dynamics can give rise to new effective microscopic structures. The changes microstructure in turn have dramatic consequences for condensate material …
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AN EXAMINATION OF THE DOMAIN ARCHITECTURE OF THE IOC2 AND IOC3 SUBUNITS OF THE ISW1 COMPLEXES IN SACCHAROMYCES CEREVISIAE
… True to this function, it exhibits directional remodeling activity and the ability to space nucleosome arrays at ~175bp increments, promoting the formation of a repressive chromatin structure. ISW1b lacks both of these biochemical properties and was found localized within the coding regions of …
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Time-dependent mechanical behavior of newly developing matrix of bovine primary chondrocytes and bone marrow stromal cells using Atomic Force Microscopy
… relations linked to the growth/remodeling activity of articular cartilage in order to achieve the mechanically functional cartilage tissue engineered constructs. While the biomechanical testing of the macroscopic tissue would give an overall outcome of multiple interactions …
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Cell Kinetics of Osteoblast Histogenesis in Evolving Rabbit Secondary Haversian Systems Using a Double Labeling Technique with [³H]-Thymidine and Bromodeoxyuridine
The mechanism for internal cortical bone remodeling is orchestrated by the evolving secondary Haversian systems (SHSs), which originate on the surfaces of Volkmann's canals. During this coupled process, a cortical tunnel advances by the cutting cone of osteoclasts and closes by the bone-forming …
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The Application of Melatonin and Platelet-Rich Plasma in the Development of a Bioactive Calcium Aluminate Bone Regenerative Scaffold
… signaling and free radical scavenging activity, respectively. Thus, it was hypothesized that melatonin and/or PRP would provide osteoinductive properties to CA scaffolds to promote bone regeneration in a rodent model of critical-size calvaria defects. Modified CA scaffolds (CA-Mel) were …
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MECHANISMS OF CHROMATIN REMODELING BY ISWI FAMILY OF REMODELERS: A FUNCTIONAL AND STRUCTURAL INSIGHT INTO THE ROLE OF THE Itc1 SUBUNIT OF ISW2 REMODELING COMPLEX
… and space nucleosomes. These ATP-dependent remodeling complexes have a relatively small number of subunits (2-4) as compared to other classes of remodelers such as SWI/SNF, RSC and INO80/SWR-C. The accessory subunits of some of the ISWI remodelers from yeast have been shown to contact …
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STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE ISW2 CHROMATIN REMODELING COMPLEX
… for their role in regulation of ISW2 activity both in-vitro and in-vivo. It appears that there are distinct modes of ISW2 regulation by these domains. Mutation of a patch of five acidic amino acids on the region of ATPase domain that contact SHL2 was found to be crucial for both ISW2 …