Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"Release mechanism"”.
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The use of ATR-FTIR to probe the release mechanism from hydrophilic matrices.
… used in the pharmaceutical industry as control release agents in solid oral dosage formulations. One of the key parameters that controls release in such systems is the distribution of exipients within the formulation, which in turn is governed by the processing and manufacturing procedures. This …
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Investigating Spatiotemporal Kinetics, Dynamics, and Mechanism of Exosome Release
… step, very little is known about exosomes release mechanism and dynamics. To further our understanding of exosomes, specifically their secretion, my work has focused on investigating spatiotemporal dynamics and kinetics of both MVEs and MVE interacting proteins. We visualized and …
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Physical and practical limits of a biomolecular control system using nanoparticles and electromagnetic field irradiation
… actuating their activity. This thesis is on the mechanisms by which both ultrafast pulsed laser irradiation and radio frequency alternating magnetic fields (RFMFs) can be used as energy sources for the proposed biomolecular activity switch. The thesis reports on the quantification of a fs-pulsed …
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Microbubble cell actuator
… array, hold them against a flow, and selectively release them. The release mechanism uses a vapor microbubble as a means of volume expansion to create a jet of fluid that ejects a particle. The theory, design, and testing are described, and successful operation of the device is demonstrated. …
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Studies into the release mechanisms of human placental lactogen in vitro
A procedure to study the in vitro release of HPL was developed. Hormone release, partially uncoupled from hormone biosynthesis, was measured by incubating placental fragments in physiological salt solutions for short periods. The effect of test substances and different ionic environments on HPL …
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Investigation into reliability and performance of an implantable closed-loop insulin delivery device
… future device designs. To study insulin delivery mechanism and kinetics from the device, fluorescently labelled human insulin (FITC-insulin) was synthesised and characterised using RP-HPLC and MS, to produce a product with predominantly di-labelled conjugate (>75%) with no unreacted FITC or native …
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Comparison of performance for visual feedback and cursors in mid-air grasping of 3D objects
… simple task that uses tools through a grasp and release mechanism, in a virtual environment that compares visual feedback methods used in other studies against techniques meant to inform the user of the bounds of the simulation in advance, known as feedforward techniques. Data collected finds …
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Eshelby-like forces in elastic structures: theory, experiments and applications
… structure is generated through the motion and release mechanism of flexural and torsional energy. This configurational force, analytically derived through different approaches and experimentally validated, provides counterintuitive but crucial effects in elasticity. In particular, it affects …
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The Cellular Basis for Hearing
… of hearing. This is attributed to motile mechanisms in hair cells, ``electromotility'' which indicates length change of outer hair cell driven by AC electrical potential across the membrane, and ``hair bundle motility'' which is an active movement of the hair bundle of hair cells. We first …
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The development of novel electroanalytical interfaces for point of care diagnostics
… processing. Here a novel controlled silver release mechanism was assessed. Silver release was found to be dependent upon the thiol structure. This has possible future applications to the development of methods to prevent biofilm formation, although the full mechanism of silver-thiol release …
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Effects of Carbon on Fracture Mechanisms in Nanocrystalline BCC Iron - Atomistic Simulations
… carbon on fracture toughness and the mechanisms of fracture were investigated. It was found that as the average grain size changes the dominant energy release mechanism also changes. Because of this the role of the intergranular carbon changes and these mechanisms compete affecting the …
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Modulatable endosomalytic, intracellularly biodegradable vectors for gene delivery
… via endocytosis, provide a tunable endosomal release mechanism, and provide a degradable backbone in order that the DNA can be released once in the cytoplasm. The reducible polycations (RPCs) were synthesized from 2COPs. The sizes, surface charges and the stability of RPC polyplexes under the …
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The effects of intermediate-scale wind disturbance on forest composition, structure, and succession with implications for management
… classes. This disturbance acted primarily as a release mechanism for advanced regeneration and stems in the midstory. Our results can be used to refine silvicultural prescriptions that attempt to minimize the disparity between managed and unmanaged stands and to promote intra-stand heterogeneity.
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The effect of fatigue on the caffeine sensitivity of skeletal muscle sarcoplasmic reticulum
… of the muscle to agents which evoke Ca²⁺ release from the SR. The purpose of this study was to determine whether the SR Ca²⁺ release mechanism of fatigued muscle is less sensitive to caffeine than that of rested muscle. Following a fatigue bout of electrically evoked tetanic pulses, the …
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The influence of Hall currents, plasma viscosity and electron inertia on magnetic reconnection solutions
… solar corona. Magnetic reconnection is the only mechanism which allows the magnetic topology of magnetized plasmas to be changed. Many of the dynamic processes in the Sun's atmosphere are believed to be driven by magnetic reconnection and studying the behaviour of such phenomena is a key step to …
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Studies of Arctic halogen chemistry from the snowpack to the gas phase
… of atmospheric Cl<sub>2</sub>, the source and release mechanism has not yet been determined. ^ This work describes experiments conducted during February 2014 in Barrow, Alaska, where in-snowpack production of BrCl and Cl<sub>2</sub> were observed. These measurements were accompanied by vertical …
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Effects of Obesity on Balance Recovery in Response to Small Postural Perturbations
… of postural perturbation, yet the biomechanical mechanisms as to why obese individuals fall more often is unclear. Therefore, the goal of this study was to investigate the effects of obesity on balance recovery in response to small forward postural perturbations. Twenty male participants, …
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Advancing prostate cancer therapy: synthesis and characterization of docetaxel-loaded magnetic iron oxide nanoparticles for controlled drug release.
… nanoparticles (Fe3O4NPs) for controlled drug release in prostate cancer cells. In this study, Fe3O4NPs were synthesized by the co-precipitation, functionalized with folic acid (FA), loaded with DXL and encapsulated with polyethylene glycol (PEG). Structural analysis was done using …
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Study of the enhancement effect of cyclopentadecanolide on protein permeation through lipid membranes
… (CPE-215RTM) as a permeation enhancer in protein release through lipid bilayer membranes. We successfully designed a novel in-vitro membrane permeability model using liposomes and performed a series of transmembrane protein release experiments. These were carried out under a wide range of …
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