Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"Release kinetics"”.
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Self-assembled thin films with tunable release kinetics for biomedical applications
… regards to the types of drugs as well as their release kinetics, especially if more than one drug is involved. Furthermore, for implantable devices biocompatibility and biodegradability are important considerations for minimizing undesirable side effects. This thesis utilizes the layer-by-layer …
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The Role of Phase Inversion in the Drug Release Kinetics of Injectable Polymer Solutions
… induced phase inversion plays in the protein release kinetics of injectable drug delivery devices are presented. In situ optical techniques coupled with scanning electron microscopy (SEM) and high performance liquid chromatography (HPLC) were used to examine the relationship between the phase …
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Design, synthesis, and evaluation of release kinetics of novel LFA-1 and TLR-4 inhibitor prodrugs for localized immunomodulation.
… details the development and evaluation of release kinetics of novel prodrugs of TLR-4 antagonist TAK-242, which inhibits the early stages of innate immune inflammation, the development and biological evaluation of novel LFA-1 inhibitor compounds, which inhibit early T-cell trafficking of …
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Computational and Experimental Studies of Controlled Release Drug Delivery: Effect of Microsphere Diameter and Drug Size on in-Vitro Release Kinetics
… small-molecule, protein and oligonucleotide release have been clarified in this work.
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Study of Ion-Transport and Release from Carboxymethyl Cellulose and other Polymer Networks
… on the soil as well as on the crops. The rapid release of nutrients from fertilizers not only prevents crops from properly absorbing them, but also destroys the quality of the soil, while unabsorbed nutrients damage our environment through the hydrological cycle. Slow-release fertilizers have …
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Therapeutic contact lenses for extended drug delivery
… lenses for drug delivery is that most drugs are released in a few hours, which limits their application for extended delivery. In this dissertation, we develop novel drug-eluting contact lenses that are capable of achieving extended in vitro drug delivery. In our first study, we describe the …
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Layer-by-Layer Systems for Craniomaxillofacial Bone Repair
… It is becoming increasingly recognized that release rate of growth factor proteins signaling bone regeneration and vascularization is a key optimization parameter since these proteins are rapidly cleared from the body and can have safety ramifications when released too rapidly. A clear …
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DEVELOPMENT AND CHARACTERIZATION OF POLYMER-OIL NANOSTRUCTURED CARRIER (PONC) FOR CONTROLLED DELIVERY OF ALL-TRANS RETINOIC ACID (ATRA)
… limited by their inadequate drug loading and release properties. This study reports the integration of oil into PLGA to form the prototype of a hybrid drug carrier PONC. Our primary goal is to confer the key strength of lipid-based drug carriers, i.e. efficient encapsulation of lipophilic …
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Hot-melt extrusion as processing technique for multiparticulate dosage forms containing lipophilic and hydrophilic polymers
… dosage form with zero-order sustained-release properties. This study demonstrated that the in vitro and in vivo drug release kinetics could be varied by selecting a formulation with an appropriate ratio of lipophilic and hydrophilic polymers, and by changing the particle size and/or …
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Development and formulation of wax-based transdermal drug delivery systems
… naproxen in the was using microscopy, Higuchi release kinetics, HyperDSC and mathematical modelling techniques. Correlations between the results obtained via these techniques were noted with additional merits such as provision of valuable information on drug release kinetics and possible …
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Universal room-temperature stable influenza A nanovaccine
… formulation was evaluated to determine both the release kinetics and the functional stability of antigenic loadings. The results described herein motivate the further investigation of this universal, room-temperature stable IAV nanovaccine.
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Regulated release of a novel non-viral gene delivery vector from electrospun coaxial fiber mesh scaffolds
… scaffolds that act as reservoirs and controlled release constructs. To fabricate a novel gene delivery agent a commercially available cationic polymer, poly(ethylenimine), PEI, was chemically conjugated to a ubiquitous glycosaminoglycan, hyaluronic acid (HA). The novel polymer, PEI-HA, had …
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Toward a drug delivery coating for intraocular lenses
… focused on rational polymer design for tailored release, incorporation of hydrophobic small molecule therapeutics, and controlled multi-agent release. Fabrication rules and design tools necessary to create hydrolytically degradable polyelectrolyte multilayer films with preprogrammed advanced …
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Biosynthesis of Poly-3-Hydroxybutyrate and its Application in Controlled Drug Delivery
… compared for their physical properties and drug release kinetics and their release kinetics were found to be comparable. However, P(3HB) microspheres were more suitable for applications as their degradation products were found to be less acidic than that of PLLA microspheres. Tacrolimus …
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Investigating the Mechanisms and Kinetics of Circulating Tumour DNA Release to Improve its Clinical Utility
… However, the mechanisms that dictate ctDNA release kinetics have not been thoroughly investigated, hampering the interpretation of such ctDNA kinetic patterns. To address this gap, I first evaluated the biological underpinnings that dictate ctDNA release using preclinical models of HNSCC. To …
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Development and Applications of Opioids Alternatives for Pain Management
… delivery systems were developed to refine the release kinetics of TTX. Initially, a hydration-induced void-containing hydrogel system was created to encapsulate TTX physically. Following a simple hydration process between the polymer and the TTX solution, TTX was successfully encapsulated in …
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Developing & applying a miniaturized active microchip device
… deliver drugs with precise temporal control over release kinetics. An intracranial MEMS based device was developed to deliver the clinically utilized chemotherapeutic temozolomide (TMZ) in a 9L rodent glioma model. An activation mechanism based on thermally induced membrane failure was developed …
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NANOPARTICLE DEPOT FOR INTRAPERITONEAL CHEMOTHERAPY OF OVARIAN CANCER
… temperature-induced crystallization. Dissolution kinetics of PNC could be determined by the light scattering method rather than the dialysis method due to drug reprecipitation caused by diffusion barrier. PTX release profiles from PNC-gel and PTX precipitate-gel (PPT-gel) were estimated in both …
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Biodegradable Hydrogel Composites for Growth Factor and Stem Cell Delivery in Osteochondral Tissue Engineering
… osteochondral tissue. First, we investigated the release of growth factors from acellular hydrogel composites containing gelatin microparticles (GMPs) to stimulate the repair of cartilage tissue in an in vivo osteochondral defect model. Transforming growth factor-β3 (TGF-β3) with varying release …
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