Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 46 for “"Relaxivity"”.
-
High relaxivity biomolecule based contrast agents engineered for molecular functional magnetic resonance imaging
… we explore two approaches for developing high relaxivity protein-based contrast agents to address the issues of low detectability. First, we coupled monoamine sensing with the disaggregation of superparamagnetic iron oxide nanoparticles (SPIOs). Ligand detection was imparted by integration of a …
-
Studies of GD-DTPA relaxivity and proton exchange rates in tissue with implications for MR imaging of regional myocardial perfusion
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1993.
-
Studies On The Physicochemical Properties Of Eu2+ Cryptates: Implications To Contrast Agents For Magnetic Resonance Imaging
… However, the efficiency (also known as relaxivity) of these Gd<sup>3+</sup>-containing complexes decreases as field strength increases, and in the ultra-high field strength regime, the relaxivity of these complexes is decreased considerably. Because of the slow water-exchange rate of …
-
Lanthanide Functionalised gold nanoparticles as MRI contrast agents
… were then loaded with gadolinium. The relaxivity of gadolinium loaded gold nanoparticles were studied using inversion recovery method and compared with commercially available MRI contrast agents (i.e. Gd-DTPA). The Gd-loaded AuNPs showed only a moderate increase in their relaxivity as …
-
Responsive, multimodal imaging agents for MRI: advancing the detection of metals and oxidized species implicated in neurodegenerative disorders
… the nature of the iron oxide nanoparticles. Thee relaxivity of the nanoparticles was found to be dependent on the total anisotropy of the particles themselves, which is in turn a function of the size, shape, composition, surface coating, and interparticle distance of the nanoparticles. Responsive, …
-
Gadolinium Endohedral Metallofullerenes for Future Magnetic Resonance Imaging Contrast Agents
… and dynamic light scattering (DLS). In addition, relaxivity data were obtained for the two metallofullerenes, and the results showed that Gd3N@C84 metallofullerenol had enhanced relaxivity compared to Gd3N@C80 metallofullerenol. This result is consistent with the observation of magnetic resonance …
-
Nitroxide Spin Labels as NMR Contrast Agents: Delivery, Metabolism and Relaxation
… lack of tissue selectivity, and relatively low relaxivity of nitroxides, were, in part, overcome by the use of liposomes as the delivery system.
-
Multifunctional CuS Nanoparticles for Imaging Guided Photothermal Ablation Therapy
… the doped NPs, the elements quantification, MRI relaxivity and MRI imaging were also investigated. Results: The tumor uptakes at 24 h after i.v. injection for targeted [64Cu]CuS NPs and [64Cu]CuS-PEG NPs was about 10% and 5% ID/g, respectively. The PTA results revealed the 100 % necrotic area in …
-
Η εξέλιξη των σκιαγραφικών μέσων που χρησιμοποιούνται στη μαγνητική τομογραφία
… τους στην αύξηση της παραμαγνητικής απόκρισης (relaxivity). Δεδομένης της τοξικότητας του ελεύθερου ιόντος Gd³⁺, αυτό χηλοποιείται με οργανικούς παράγοντες, σχηματίζοντας γραμμικά ή μακροκυκλικά σύμπλοκα. Τα μακροκυκλικά σκιαγραφικά παρουσιάζουν αυξημένη θερμοδυναμική και κινητική σταθερότητα …
-
A contrast agent for MRI of calcifications in breast cancer
… measurements were used to estimate the apparent relaxivity of the hydroxyapatite contrast agent to be >1000 s-I/mM. The targeted agent relaxivity is enhanced more than a 100-fold compared to conventional untargeted gadolinium contrast agents due to the restricted rotational motion of the contrast …
-
Calibrating NMR response to capillary pressure curves in fine grained lithologies: Pretty Hill Formation, Otway Basin
… factors such as magnetic susceptibility, surface relaxivity and aspect ratio. Therefore, using the NMR response to estimate capillary displacement pressures in iron-rich, fine grained rocks is not recommended. However, further studies in rocks of low magnetic suscepibility might yield more …
-
The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents
… to that of commercial contrast agents. The relaxivity of the gadolinium(III) complex formed with the ligand l,4,7-tris(carboxymethyl)-10-(l-(4-nitrobenzyl)-2-methyl benzimidazole)-1,4,7,10-tetraazacyclododecane (34) is 6.22 mM"1 s" 1 , with the relaxivity of the gadolinium(III) complex …
-
Polymer-mediated assembly of MRI contrast agents and their use in imaging of vascular defects
… properties of MR imaging probes to improve their relaxivity and accumulation at sites of interest. The first part of this thesis focuses on the design and development of gadolinium-based contrast agents. Chapter 2 describes the synthesis of a polymeric fastener to anchor gadolinium to the surface …
-
The Design of Stable, Well-Defined Polymer-Magnetite Nanoparticle Systems for Biomedical Applications
… examined through colloidal modeling and DLS. The relaxivity of the complexes was related to aggregation behavior observed through DLS. This indicated the presence of a hydrophobic interaction between the PPO layers of neighboring complexes. When this interaction was large enough, the complexes …
-
HIGH FIELD MAGNETIC RESONANCE IMAGING-BASED GEL DOSIMETRY FOR SMALL RADIATION FIELDS
… imaging (MRI), which detects changes in relaxivity due to gel polymerization. Spatial resolution for dose readout is limited to 0.25-0.5mm pixel size because of available the magnetic field strengths (1.5T and 3T) and the stability of polymer gelatin at room temperature.
-
Fullerene Based Nanomaterials for Biomedical Applications
… contrast agents, given their inherent higher 1H relaxivity than most commercial contrast agents. The fullerene cage is an extraordinarily stable species which makes it extremely unlikely to break and release the toxic Gd metal ions into the bioenvironment. In addition, radiolabeled metals could …
-
Nuclear magnetic resonance readable sensors
… which produce analyte-responsive changes in MR relaxivity. We show that MR responsive calcium-crosslinked and pH-swelling hydrogels can be incorporated within discrete sensors.
Page 1 of 3