Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Rekombinantes Protein"”.
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Plasmodium falciparum calciumabhängige Proteinkinase 1 (PfCDPK1): Strukturelle und funktionelle Charakterisierung
… der Parasiten essentiell ist. Als mögliche Zielproteine und Vermittler der Ca2+-induzierten Signaltransduktion wurden unter anderem calciumabhängige Proteinkinasen (CDPKs) identifiziert. CDPKs haben in Pflanzen und einigen Spezies der Protozoen, so auch in P. falciparum, eine Schlüsselfunktion …
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Yeast and plant cells as biofactories for recombinant proteins : evaluation of novel expression and downstream processing strategies
… applicability of several novel developments in protein purification and analysis technologies – in particular immobilized metal ion affinity chromatography (IMAC), expanded bed adsorption (EBA) and biomolecular interaction analysis (BIA) – for recombinant protein production in yeast and tobacco …
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Entwicklung von Fermentationsprozessen zur Produktion rekombinanter Antikörperfragmente in Pichia pastoris und Nicotiana tabacum
Being partly funded by the EU-project "Processing technology for recovery of recombinant antibody produced in crop plants" (FAIR-PL-CT96-1039), the aim of this work was to provide approximately 500 mg of the recombinant single-chain antibody fragment 4813 to enable the development of a synthetic …
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Charakterisierung der Proteinkinase DYRK1A : Substrat- und Autophosphorylierung
… encodes an evolutionary highly conserved protein kinase. Due to different animal models and its genomic localisation on human chromosome 21, is it considered a candidate gene in mental retardation of the Down-syndrome. Little was known about the cellular function of DYRK1A, but comparison …
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Herstellung und Charakterisierung von rekombinanten, ETA-basierten CD64-Immuntoxinen zur Bekämpfung von dysregulierten Makrophagen bei chronischen Hautentzündungen
Dysregulated, activated macrophages play a decisive role in different chronically inflammatory cutaneous diseases. The fact that a selective elimination of the high CD64 expressing macrophages, through CD64 immunotoxin (full length antibody with a toxin), results in a resolution of chronic …
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Herstellung und Charakterisierung hochaffiner Inhibitoren für die Zytokine IL-6 und LIF basierend auf den Liganden-bindenden Domänen ihrer Rezeptor-Untereinheiten
Cytokines are small secreted proteins produced by different cell types in nearly all tissues. They are used as intercellular mediators being involved in the regulation of immunity and inflammation. Dysregulated cytokine production plays an important role in the development and progression of …
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High-throughput experimentation for microscale cultivations and recombinant protein expression
In this work, common high-throughput cultivation processes in microtiter plates are investigated with the BioLector technology. It is demonstrated that extensive monitoring of key parameters (i.e. biomass and product formation) in microscale cultivations enables a profound understanding and hence …