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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"Regulatory sequences"”.
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Computational modeling of gene expression from regulatory sequences
… regulation of gene expression is dictated by regulatory DNA sequences, often called cis-regulatory modules (CRM; also known as “enhancer”), that contain specific binding sites for regulatory proteins (transcription factors, TF). The assembly of TFs bound on a CRM drives the desired expression …
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Computational Models of Function and Evolution of cis-Regulatory Sequences
Gene expression is controlled by regulatory DNA sequences, often called cis-regulatory modules or CRMs in higher organisms. Even though complete genomes are available in many species, a catalog of CRMs is far from complete. Meanwhile, how basic building blocks of CRMs, called transcription factor …
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Genome-wide analysis of transcriptional expression programs, regulatory networks and Cis-regulatory sequences in Saccharomyces cerevisiae
… can also provide clues about the identity of the regulatory regions within DNA, the structure of global regulatory networks and the regulation of DNA-binding proteins. These and other insights are presented here based on our genome-wide studies of transcriptional regulation in the yeast …
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A detailed investigation into potential genes and their variants regulatory sequences causing endometriosis and how the environment may impact upon these
Introduction Endometriosis is an inflammatory and chronic gynaecological condition leading to infertility and severe chronic pelvic pain. Although effecting 10% of women worldwide, there is limited knowledge on the aetiology and pathophysiology of the disease. Research into the condition has shown …
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Statistical mechanical modeling of eukaryotic gene regulation
Gene expression patterns are regulated by gene regulatory networks. Central to transcriptional regulation of gene expression is the regulation of the quantities of transcription factors (TFs) bound to genomic regulatory sequences. This thesis work is built on statistical mechanics to study the …
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Quantifying the functional and evolutionary relationships among sequences, transcription factor binding and gene expression
A central challenge in regulatory genomics today is to understand the precise relationship between regulatory sequences, transcription factor (TF) binding and gene expression. Many studies have discussed how TFs recognize their DNA binding sites. However, it is not well understood how the various …
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Conserved recombination patterns across coronavirus subgenera
… both from controlled experiments and in genome sequences sampled from nature, that patterns of recombination in coronaviruses are nonrandom and that this is likely attributable to a combination of sequence features that favour the occurrence of recombination breakpoints at specific genomic …
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CRISPR-based functional genomics to study gene regulatory architecture and consequences of genetic variation
… noncoding genome contains the vast majority of sequences that regulate the expression of genes (some regulatory sequences reside in coding regions). The classes of sequences that make up regulatory sequences include promoters, enhancers, silencers, insulators, and repressors, amongst others. …
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Genomic Exploration of Transcriptional Regulation and Evolution in Vertebrates
… expression of genes and their interactions. Regulatory sequences encoded in the genome stipulate the necessary instructions interpreted by sequence-specific transcription factors (TFs) to control the spatial-temporal output of gene expression. Detection of cis-regulatory signals is …
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Investigation of Transcriptional Regulation of 5'-Nucleotidase in Dictyostelium Discoideum
… cells during development. To identify cis-acting regulatory sequences, a series of 5' and internal promoter deletions were generated and fused to a luciferase reporter gene. The reporter activity driven by the 1,212 bp promoter started at the early aggregation stage, in agreement with temporal …
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Analysis of organ-specific gene expression in soybean
… conferred by 5$\sp\prime$ and 3$\sp\prime$ regulatory sequences of the seed-lectin gene of soybean (Glycine max) on the expression of a foreign gene. The reporter gene $\beta$-glucuronidase (GUS), was linked to the 5$\sp\prime$ and 3$\sp\prime$ sequences of the lectin gene and transferred …
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Genetic determinants of NEIL2 transcription
… influence NEIL2 transcription, including cis-regulatory sequences and sequence polymorphisms, were unknown. We hypothesize that cis-regulatory sequences in the 5’ upstream region of NEIL2 regulate gene transcript levels and that SNPs proximal to these sequences impact gene regulation and thus …
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Structure and expression of a U1 snRNA gene from Arabidopsis thaliana
… significance. The promoter of U1a snRNA contains regulatory sequences previously described for other plant snRNAs: the CAAT box, $-$78 sequence, TATA box and 3' box. The U1a promoter also contains the octamer motif, a sequence element commonly found in vertebrate snRNA genes. In addition, U1a …
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Characterizing and predicting enhancers in the human genome
Characterizing the functions of sequences in the human genome is crucial for the study and treatment of human disease. Though it is known that approximately 5% of the human genome is conserved, about 40% of these sequences have yet to be characterized, many of which may be important players in …
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Transcriptional Regulation Of Adipocyte Function
… under the control of overlapping leptin regulatory sequences. Cis elements that confer qualitative and quantitative control of the leptin gene are located between — 762B and +8kb relative to the transcription start site. Since luciferase is driven by leptin regulatory sequences in …
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Bioinformatic methods for analyses of epigenome and RNA interactome
… complete, particularly on non-coding RNAs and regulatory sequences. Epigenomic modifications and variations were considered to contribute to the diversity of functions found across different cell types, play key roles in the establishment and maintenance of cellular identity during development. …
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Glia Delimit Shape Changes Of Sensory Neuron Receptive Endings in C. elegans
… of TTX-1 and perhaps also ZTF-16 to ver-1 regulatory sequences. Our results demonstrate that experience-induced changes in glial compartment size provide spatial constraints on neuronal receptive ending growth.</p>
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Function of a C-rich region in the transcriptional regulation of the glycogen phosphorylase-2 gene in Dictyostelium discoideum
… deletions have revealed the presence of several regulatory regions which contain repeated sequence elements; TA-boxes, the TAG-boxes, and C-boxes (Sucic et al., 1993; Rutherford et al., submitted). The C-rich regulatory region contains two C-box repeats and is the most proximal of the regulatory …
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Cloning a Putative DNA-Binding Protein Controlling the 5'LTR of the Copia Element in Drosophila
… results in phenotypic change in Drosophila. The regulatory sequences, controlling copia expression, are located within the 5'LTR. The DNA sequence in the 5'LTR and in the location between downstream of entire the 5' LTR and the initial translation site have been identified by mobilityshift …
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Analysis of combinatorial gene regulation with thermodynamic models
Transcriptional control is a key regulatory mechanism for cells to direct their destinies. A large number of transcription factors (TFs) could simultaneously bind to a regulatory sequence. With the constellation of TFs bound, the expression level of a target gene is usually determined by the …
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