Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 205 for “"Regulatory mechanism"”.
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Regulatory Mechanism of the RNAi Pathway
… of C3PO and La reveal a general concept that regulatory factors are required to remove Ago2-cleaved products to assemble or restore active RISC. The robust reconstitution system establishes a powerful platform for in-depth studies of the assembly, function, and regulation of RISC. Similar to …
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An evolutionarily conserved regulatory mechanism for endosomal membrane trafficking
… hence a lot or our knowledge about the molecular mechanism that regulates membrane traffic has come from experimentally tractable model organisms such as Saccharomyces cerevisiae. The work presented in this thesis demonstrates that the mammalian SNARE protein, syntaxin 16 (Sx16), is a functional …
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Structure and regulatory mechanism of human uncoupling protein 1
… and its nucleotide inhibition and activation mechanisms. Initially, attempts were made to grow three-dimensional crystals for X-ray crystallography, but later cryogenic electron microscopy (cryo-EM) and single particle analysis were used to determine the structure. Human UCP1 was purified from …
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REGULATORY MECHANISM OF DUSP16 IN CANCER RESISTANCE TO PLATINUM-BASED THERAPIES
Platinum-based chemotherapeutic agents remain the backbone of treatment for various solid tumours, and resistance to platinum-based therapies is the main limitation. In this study, the role DUSP16/MKP7 in cancer resistance to chemotherapy drugs was investigated. We observed that higher expression …
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Elucidation of the regulatory mechanism of SWEET11 phloem parenchyma cell-specific expression
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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An ancestral regulatory mechanism underlies Hoxd gene expression in both developing genitals and digits
… a terrestrial life, we investigated whether the regulatory circuitries would also share similarities, indicating a common phylogenetic origin. We show that the transcription of posterior Hoxd genes in the distal part of these different appendages depends, in both cases, upon enhancer sequences …
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Local Protein Turnover As a Regulatory Mechanism of Growth and Collapse of Neuronal Growth Cones
… entwickelt, welche es ermöglichen den Mechanismus der Regulation von Strukturproteinen und der entsprechenden Signalwege in neuronalen Wachtumskegeln, sowie grundsätzlich in lebenden Zellen, zu untersuchen.
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Evidence for reversible phosphorylation as a post-translational regulatory mechanism in the chlorophyll catabolic pathway
… A better understanding of the post-translational mechanisms governing activity of one enzyme in particular, pheophorbide a oxygenase (PaO), is especially desirable as PaO catalyzes the oxidative opening of the porphyrin ring structure, considered to be the key regulatory point in chlorophyll …
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Cognitive reactivity: Evidence of a regulatory mechanism that compensates for dysphoric mood and mediates depression vulnerability
… might be associated with a dysfunctional regulatory mechanism involved in mediating the affective response. The positive, adaptive responses observed in ND suggests they were able to compensate for a dysphoric mood and restore affective equilibrium, which was less evident in FD and almost …
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H-NS Counter-silencing as a Primary Regulatory Mechanism of Curli Gene Expression in Salmonella Typhimurium
… as a counter-silencer of H-NS, although the mechanism for this process awaits further characterization. Additionally, we identified a previously uncharacterized input for biofilm regulation. Vitamin B12 likely serves as an allosteric regulator of MlrA and may serve as a photosensor to trigger …
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Biophysical studies of the allosteric regulatory mechanism of Syk tandem SH2 domains interacting with immunoreceptor tyrosine-based activation motifs
… (>20 Å) from the binding sites and the detailed mechanism of this long-distance allosteric regulation is largely unknown.</p> <p>A series of biophysical experiments, such as NMR and ITC, have been done to understand this allosteric mechanism. The results revealed interesting changes in the …
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Histone Variant H2A.Z Substitution Mediated by the SWR1-like Complex is a Novel Transcriptional Regulatory Mechanism Controlling Defense Genes and Immunity in Plants
… To further gain insight into the molecular mechanism of this H2A.Z replacement in defense signaling, I performed chromatin immunoprecipitation with H2A.Z and found that infection with P. syringae leads to an elevated level of chromatin associated with H2A.Z including defense genes such as …
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Prolactin Effects on Nigrostriatal and Mesolimbic Dopaminergic Neurons: In Vivo and In Vitro Studies
… dopaminergic neuronal activity and its possible regulatory mechanism were examined.
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Transcriptional regulation of the prolactin gene in turkeys
… behavior in birds, and understanding the regulatory mechanism(s) of Prl gene expression will provide fundamental information to manipulate Prl production for better reproductive performance in turkey hens.
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Unraveling the Dynamics of Ser126 Phosphorylation in Paxillin: A Focus on Phosphatase Activity
… Ser126, a previously unexplored mechanism. Using recombinant paxillin and in vitro kinase assays, we confirmed that PKC phosphorylates Ser126. Inhibition studies in endothelial cells revealed that calcineurin mediates Ser126 dephosphorylation. Phosphorylation at Ser126 enhances …
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Integration and Excision Mechanism of Bacteroides Conjugative Transposons
The third project is about the regulatory mechanism of RteB on CTnDOT. RteA and RteB are shown to be global regulators that regulate many genes on Bacteroides host. Whether RteB regulates CTnDOT and NBU1 excision directly or not is investigated in this study. Both RteB and the mutant are …
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Stretch-Dependant Tonic Force Maintenance in Rabbit Epigastric Artery
… characterizes hypertension and understanding the regulatory mechanisms of VSM may provide some insights to specific treatment of hypertension. Upon muscle stimulation, Ca2+, myosin light chain (MLC) phosphorylation, crossbridge cycling rates and force increase to high levels, but with time, force …
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Investigation of carbon catabolite repression in Clostridium beijerinckii NCIMB 8052
… catabolite repression is controlled by a global regulatory mechanism, central to which is an imperfect palindromic sequence, the cre element, which is recognized by a protein of the GalR-LacI family, the CcpA protein. A ccpA homologue, regA, has been previously identified in C. acetobutylicum …
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In Vitro and In Silico Analysis of Osteoclastogenesis in Response to Inhibition of De-phosphorylation of EIF2alpha by Salubrinal and Guanabenz
… guanabenz alter osteoclastogenesis? If so, what regulatory mechanism mediates the process? It was hypothesized that p-eIF2alpha could attenuate the development of osteoclast by regulating the transcription factor(s) amd microRNA(s) involved in osteoclastogenesis. To test this hypothesis, we …
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Studies on the autophagy gene WIPI4 and its interactor UBR5
… regulate autophagosome closure, the exact mechanism of this process has remained unclear. This thesis explored the regulatory mechanism of GABARAP by WIPI4. GABARAP is a potential closure regulator and is also required for expansion and fusion steps of autophagy. I identified that WIPI4 …
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