Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"Regulatory circuit"”.
-
A Host Regulatory Circuit of HSV Gene Expression
… data indicate that a previously unrecognized regulatory circuit exists, which may control not only lytic but also latent HSV infection.
-
A synthetic positive feedback based gene regulatory circuit
… reengineering and rewiring of pathways and gene regulatory networks for novel uses, and sometimes for mimicking natural systems for various uses in various disciplines gradually acquired the name “synthetic biology”. Synthetic biology, with foundations rooted in multiple disciplines like …
-
Rest Regulatory Circuit Controls Distinct Oncogenic Properties of Glioblastoma Stem Cells Through Specific Micrornas
<p>Glioblastoma Multiforme (GBM) is the most common and aggressive primary malignant brain tumor in adults. With an average survival of only 12-16 months the prognosis for GBM patients remains dismal, with less than 5% of patients surviving 5 years. New mechanism-based approaches are necessary for …
-
The quorum-sensing regulation of Vibrio fischeri : novel components of the autoinducer/LuxR regulatory circuit
In the marine bacterium Vibrio fischeri two intercellular homoserine-Iactone signal molecules (luxI-dependent 30C6-HSL and the ainS-dependent C8-HSL) and the transcriptional activator LuxR regulate the luminescence system in a cell-density dependent manner by a process termed quorum sensing. In …
-
The quorum-sensing regulation of Vibrio fischeri : novel components of the autoinduce/LuxR regulatory circuit
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.
-
Molecular mechanisms of regeneration initiation and dorsal-ventral patterning in planarians
… and maintenance of DV polarity. Subsequently, a regulatory relationship between admp and a bmp homolog was described. In this regulatory circuit, admp activates bmp expression but bmp represses admp expression. This arrangement results in a DV regulatory circuit that is buffered against …
-
Regulation of meiosis I chromosome segregation by Spol3 and Cdc5 in Saccharomyces cerevisiae
… cycle and defines a component of the complex regulatory circuit necessary for the specialized meiotic divisions.
-
Regulation of virulence in Salmonella enterica
… and themselves, forming a complex feed-forward regulatory loop to control SPI1 expression. The production of the SPI1 T3SS system is tightly controlled, with many regulators and environmental conditions known to affect hilA expression. We provide a classification of these various regulatory …
-
Hsp70-Mediated Regulation of Hsf1 Transcriptional Activity In Saccharomyces Cerevisiae
… Recent advances in the understanding of this regulatory circuit in <em>Saccharomyces cerevisiae</em> have shown that the Hsp70 Ssa1 acts as a sensor for some proteotoxic stresses and is capable of a direct interaction with Hsf1. This work continues to explore the complex regulatory interaction …
-
Engineered E. Coli That Detect and Respond to Gut Inflammation Through Nitric Oxide Sensing
… of engineered microbes. The synthetic gene regulatory circuit described here regulates gene expression through the activation of a permanent DNA switch in response to nitric oxide produced by inducible nitric oxide synthase. The detection of nitric oxide initiates the expression of a DNA …
-
Stochastic modeling of inducible logical gates in Escherichia coli
… biological systems, with a focus on gene regulatory networks, is presented. We extend a previous study of a logical AND gate system by observing the effect of individual components of this system on its functionality using experimental techniques and computational models. The previous AND …
-
Adeno-Associated Virus-Based Gene Delivery Approaches for Tissue Engineering
… consolidated red/far red light activatable gene regulatory circuit was pursued with the intent to tune levels of bone morphogenetic protein-2 (BMP-2) expression. The assembly of a large construct had its share of obstacles that eventually led to a downsized strategy, and a number of lessons were …
-
Understanding small RNA-mediated post-transcriptional regulation of Salmonella pathogenicity island 1 activator HilA in Salmonella typhimurium
… epithelial cells. Many environmental and regulatory signals control SPI1 gene expression, but in most cases, the molecular mechanisms remain unclear. Many regulatory signals control SPI1 at a post-transcriptional level, and we have identified a number of small RNAs (sRNAs) that control the …
-
Characterization And Identification Of Novel Regulators Of The Synthesis Of Phospholipids
… enzymes. In addition to this well-characterized regulatory circuit controlled by the trans-acting factors Ino2, Ino4, and Opi1, this dissertation shows that inositol pyrophosphates are novel regulators of the synthesis of inositol and phosphatidylinositol that control <em>INO1</em> …
-
The Role of the Proneural Transcription Factor ASCL1 in Neuroblastoma Cell Division and Differentiation
… are epigenetically regulated, a core regulatory circuit (CRC) of transcription factors maintaining their highly proliferative, developmental state. In subtype MS neuroblastoma, tumours can spontaneously regress, in which case children are cured for life. The mechanisms behind …
-
Molecular mechanisms responsible for the dynamic modulation of macrophage responses to varying dosages of lipopolysaccharide
… in THP-1 cells and found it to be governed by a regulatory circuit of competitive inhibition between glycogen synthase kinase 3 (GSK3) and Akt, which promote the activity of the transcription factors FoxO1 and CREB, respectively. Super-low-dose LPS mildly activated FoxO1 and pro-inflammatory gene …
-
Regulation of Metabolic Processes by Micrornas and Class I Histone Deacetylases
… miR-378* function as integral components of the regulatory circuit formed by PGC-1beta and nuclear hormone receptors to control the overall oxidative capacity and energy homeostasis of insulin-target tissues. MiR-378/378* mutant mice do not display overt phenotypes under normal laboratory …
-
Regulation of the Salmonella Pathogenicity Island 1 Type Three Secretion System
… of SPI1 genes by binding upstream of the master regulatory gene hilA to induce its expression. HilA activates the SPI1 T3SS structural genes. Here I present evidence that hilA expression, and hence the SPI1 T3SS, is controlled by a feedforward regulatory loop. I demonstrate that HilC, HilD, and …
-
Mode of Action of Penicillin in Pneumococci: From Inhibition of Cellular Targets to Bacterial Death
… mutation, indicating that there is a regulatory interaction between the cid gene product and the amidase Chapter II, describes several attempts to characterize the cid' mutation at the molecular level. Shotgun mutagenesis by insertion-inactivation (using either insertion-duplication or …
-
Discovery of a Novel Signaling Circuit Coordinating Drosophila Metabolic Status and Apoptosis
… death, we demonstrate here that a conserved regulatory circuit also coordinates somatic apoptosis and NADPH levels in <italic>Drosophila</italic>.</p><p>Given the regulatory role of NADPH in the activation of Dronc in <italic>Drosophila</italic> and caspase-2 in vertebrates, we then attempted …