Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"Regulatory architecture"”.
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Regulatory architecture of the Pax6 locus
… a large array of long-range tissue-specific cis-regulatory elements primarily identified through multispecies sequence conservation and reporter studies. I have set out to understand how the chromatin architecture of the locus contributes to the mechanism and specificity of cis-regulatory …
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Regulatory Architecture of Non-Apoptotic Cell Death Program in C. Elegans
<p>Cell death is prevalent in animal development, homeostasis, and disease. While apoptotic cell death has been extensively studied, many dying cells in development do not exhibit apoptotic morphology, and mice lacking core apoptotic regulators have mostly normal rates of developmental programmed …
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CRISPR-based functional genomics to study gene regulatory architecture and consequences of genetic variation
… that regulate the expression of genes (some regulatory sequences reside in coding regions). The classes of sequences that make up regulatory sequences include promoters, enhancers, silencers, insulators, and repressors, amongst others. Proper regulation of genes at the right time and in the …
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A critical analysis of the South African consumer protection regulatory architecture in the retail banking sector with a focus on fair customer outcomes in the context of its developing economy
… approach analysing the interconnectedness of the regulatory framework, supervisory architecture and fairness control mechanisms will enhance delivery of fair customer outcomes. In a Twin Peaks model with multiple regulators having overlapping mandates that influence retail consumer protection, …
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Lessons for parliament emanating from the state capture commission report: towards a reformed parliamentary oversight and accountability model
… Capture. The paper does this by looking at the regulatory architecture of parliamentary oversight in terms of South Africa's constitutional scheme. This paper argues unchangingly that the Constitution, together with the Rules of Parliament, especially those of the National Assembly, empower …
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Genomic Exploration of Transcriptional Regulation and Evolution in Vertebrates
… expression of genes and their interactions. Regulatory sequences encoded in the genome stipulate the necessary instructions interpreted by sequence-specific transcription factors (TFs) to control the spatial-temporal output of gene expression. Detection of cis-regulatory signals is …
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THE DEVELOPMENTAL BASIS AND EVOLUTION OF WING COLOR PATTERN IN BUTTERFLIES
… patterning wing colors, and to characterize the regulatory architecture modulating color pattern-related function of the WntA gene. Our results revealed that WntA is essential to establish multiple pattern elements, even in highly divergent species of nymphalids and papilionids–two distant and …
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Engineering Robust and Programmable Biological Systems
… dynamics) can be achieved by engineering gene regulatory architecture and increasing the complexity of genetic networks. We further demonstrate that increasing demand for cellular resources causes resource-associated interference among noninteracting genetic devices of various complexities. …
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Regulatory variation and human disease
Non-coding regulatory regions are strongly implicated in human disease via genetic studies. However, it is currently not possible to interpret reliably and systematically the functional consequences of genetic variation within any given transcription factor recognition sequence. To lay the …
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Artificial intelligence in law enforcement: a critical analysis of the EU AI Act’s framework for protecting public values and fundamental rights
… Article 2 TEU and demand a robust and coherent regulatory response. Against this backdrop, the present Thesis examines whether the existing European legal framework, most notably Regulation (EU) 2024/1689, is adequate to ensure that AI systems deployed by law enforcement authorities operate …
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Spatiotemporal control of gene expression in Caenorhabditis elegans
… and their composition and arrangement define the regulatory grammar directing gene transcription across development. More comprehensive in vivo studies of these regulatory grammars would improve our understanding of how different patterns of gene expression are obtained across tissues. …
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Multiomic Investigation of the Human Gut Toward Insight into Childhood Inflammatory Bowel Disease Pathogenesis
… This thesis summarizes my research into the gene regulatory architecture of IBD in intestinal epithelial cells. First I assess the utility of intestinal epithelial organoids, a model of the human intestine. This system is well established and has been shown to be comparable to in vivo intestinal …
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Price and Income Dynamics in the Agri-Food System: A Disaggregate Perspective
… to restructure the agri-food system, and the regulatory architecture that governs it, in ways that make certain price developments more likely? Hitherto, there has been little in the way of sustained analysis of the connections between prices, power and redistribution in the agri-food system. …
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Bringing regulation to the fore of food regime theory: The neoliberal model of development in agriculture and beyond in theory and practice
… enables the identification of regime and regulatory aspects particular to this neoliberal capitalist era. That is, this thesis develops a mid-range perspective that enables more specific critique of the present neoliberal era pivoting around regulation and regime. This presents an …
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"Quota Measures" and "Trade-Related Investment Measures" in Oil and Gas Regulation: Reconciling Normative Conflicts between Energy-focused Regimes and WTO Rules on Energy
… applicable law’. They reveal a conflict between regulatory privileges enshrined in energy resource-focused institutions namely: OPEC as a producer-only treaty, the ECT as a sector-specific multilateral energy treaty, national energy laws on the heel of the PSNR principle as a customary …
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Equity and the crisis of development policy in developing countries: a critical analysis of the environment and climate change regulatory framework in Malawi
… enslaved by these discourses, including by the regulatory architecture that anchor these development narratives. This has negative implications for the application of equity norms despite its recognition in the Malawi Constitution as the basis for policy making. The thesis observes that a …
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Multiscale modeling of microbial communities
… in a vast array of social interactions through regulatory gene networks. The social interactions between individual cells drive the emergence of community structures, resulting in an intricate relationship across multiple spatiotemporal scales. Here, I present my work towards developing and …
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The evolution of gene regulatory landscapes in mammalian tissues
Gene regulatory landscapes are highly complex and evolutionarily unstable. Understanding how genetic and regulatory variations affect gene expression evolution is paramount to gaining insight into phenotypic divergence across species. Although gene expression programs are broadly maintained during …
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Regulatory dynamics of transcription factors TBX18 and WT1 in mouse prostate development
… of Tbx18 caused due to disruption of the gene’s regulatory structure - we were able to circumvent the perinatal lethality and investigate adult phenotypes of Tbx18 deficiency. Upon studying the histopathology of 12Gso/Tbx18- mutant adults, unexpectedly severe defects were seen in the prostate. …