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Showing 1 to 20 of 166 for “"Regulatory T cells"”.
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Cell Biology of Foxp3+ Regulatory T Cells
<p>T cells play a central role in the immune response to fight against pathogens and orchestrate other immune cells. An overreactive immune response can lead to autoimmune diseases, therefore the immune system must possess negative regulation mechanisms. In the periphery, naturally arising …
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Ex Vivo Induction of Human Regulatory T Cells
<p>Regulatory T cells (Tregs) are indispensable in the human immune system in the maintenance of self-tolerance and immune homeostasis. The dysregulation of Treg number and/or function plays a critical role in the pathogenesis of cancer, allergy and human autoimmune pathologies such as multiple …
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Pten Signaling in Regulatory T Cells and Inflammatory Disease
Regulatory T (Treg) cells suppress CD4+ T cell responses during homeostasis and inflammation to prevent autoimmunity and other immune disorders. Although the transcriptional and epigenetic programs impacting Treg cell function have been extensively studied, the signaling and metabolic pathways …
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The Development and Function of Memory Regulatory T Cells
<p>Naturally occurring CD4+CD25+Foxp3+ regulatory T cells (TReg) are a cell lineage that develops in the thymus and exits to the periphery, where they represent 5-10% of the peripheral CD4+ T cell population. Phenotypically, they are characterized by the expression of the cell surface markers CD25, …
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The role of regulatory T cells in stroke recovery
… presence of a lymphocyte subpopulation termed regulatory T cells (Tregs) appears to correlate with improved disease outcome. However, the impact of stroke on Tregs, and the contribution of these cells to stroke recovery remains under debate. Likewise, attempts at developing Treg-targeted …
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Peripheral Generation of Regulatory T Cells in Health and Disease
CD4+CD25+FOXP3+ regulatory T cells (Tregs) form an important arm of the immune system responsible for suppressing untoward immune responses. They play a role in autoimmunity, allergy, asthma, transplantation, tumors and infectious diseases. Tregs are increased in the peripheral blood of chronic …
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Development Of Regulatory T Cells Capable Of Maintaining Immune Homeostasis
The adaptive immune response, comprised of both T cells and B cells, is essential to control infections and eliminate transformed cancer cells. The success of the adaptive immune system relies on the ability to discriminate self from non-self-antigens. The thymus is the site of selection for T …
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Role and specificity of regulatory T cells during retroviral infection
… persistent infection of hematopoietic cells. The results obtained suggested that unregulated CD4+ T cell response to FV causes bone marrow pathology and anaemia. Regulatory T (Treg) cells are a subset of CD4+ T cells which have been shown to suppress immune responses and to have …
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Functional implications of TNF-receptor pathways on regulatory T cells
Contains fulltext : 112919.pdf (Publisher’s version ) (Open Access)
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Transcriptional and extracellular programs define CD4+ CD25+ regulatory T cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Studies on the differentiation of inflammatory and regulatory T-cells
… acted directly upon human CD4\(^+\) T-cells, suppressing inflammatory cytokines (IL-17, IL-21, IFN\(_y\) and IL-22) whilst enhancing regulatory markers (CTLA-4, CD25, FoxP3 and IL-10). Consistently, 1,25(OH)\(_2\)D\(_3\)-treated T-cells suppressed division of naive T-cells stimulated by …
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LNCFOXP3 CONTROLS CELL IDENTITY AND FUNCTION OF HUMAN REGULATORY T CELLS
Regulatory T cells (Treg) control immunological responses through suppression of effector cells, playing crucial roles both in physiological and pathological contexts. Treg suppressive activity correlates with the tightly regulated expression and stability of their master transcription factor …
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Investigating interplay between human regulatory T cells and oligodendrocyte lineage cells
… initially restored by oligodendrocyte progenitor cells (OPCs) that migrate to, and proliferate in the site of injury, differentiate into mature oligodendrocytes (OLs) and generate new myelin sheaths, a process termed remyelination. The signals that influence this process in the central nervous …
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Functional characterization of rat CTLA-4 and CD25+CD4+ regulatory T cells
… rat CTLA-4 was detectable only in CD25+CD4+ regulatory T cells in unstimulated rats, and was upregulated in all activated T cells. Cross-linking rat CTLA-4 led to the deactivation of anti-TCR- and anti-CD28 stimulated (costimulation) T cell responses such as reduction in activation marker …
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Phenotypic and Functional Analysis of Regulatory T Cells during Heligmosomoides polygyrus infection
Helminths are known to stimulate regulatory T cells, which have been shown to downregulate inflammatory as well as allergic conditions such as Crohn’s Disease, Ulcerative Colitis and allergic asthma respectively. However, the differences in the Tregs generated during helminth infection compared to …
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Molecular Mechanisms Underlying The Transcriptional Regulation of T Helper 17 and Regulatory T Cells
… function of other immune cell types. Naïve Th cells can differentiate into different effector subsets that are characterized by their cytokine profile and immune regulatory functions. These subsets include Th1, Th2, Th17, natural and inducible regulatory T cells (nTreg and iTreg respectively), …
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Recruitment and positioning of regulatory T cells and Th17/Tc17 in inflamed human liver
… tolerogenic organ with dual blood supply. Both regulatory lymphocytes and effector lymphocytes are present in the normal and inflamed liver along with innate immune cells. The balance between these two subsets of lymphocyte is crucial in maintaining immune homeostasis by adjusting either hepatic …
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Regulation of Murine Mast Cell Homeostasis by TGF-β1 and CD4+CD25+C Regulatory T Cells
… These studies encouraged our interest in other regulatory cytokines, including transforming growth factor β1 (TGF- β1). TGF- β1 has many cellular sources, one of which is CD4+CD25 regulatory T cells (Tregs). We wanted to determine the effects of Transforming Growth Factor (TGF) βl on mast cell …
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T-cell Receptor CDR3 Sequence but Not Recognition Characteristics Distinguish Autoreactive Effector and Foxp3+ Regulatory T-cells
<p>Regulatory T-cells (Treg) play an important role in maintaining immune tolerance to self-antigens and in suppressing excessive immune responses in the host. The source, specificity, and plasticity of the forkhead box transcription factor 3 (Foxp3<sup>+</sup>) Treg and conventional T (Tconv) cell …
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