Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 435 for “"Regulatory Mechanisms"”.
-
Regulatory Mechanisms in Innate Immunity
Innate immunity is the frontline for the host to defend against infections. This process entails the cooperation among pathogen recognition receptors, adaptor proteins, kinases, and transcription factors that elicit the production of effector cytokines. As an important transcription factor, IRF5 …
-
Elucidating the regulatory mechanisms of pterygium
Purpose: Pterygium is characterised as invasive, proliferative fibrovascular altered conjunctival tissue. The extensive vascular network is likely to significantly contribute to the progression of the disease. In the present study we investigated the effects of reduced serum (to mimic a suppressed …
-
Tryptophanase Regulatory Mechanisms in Escherichia coli
… high-level (pulse) signal. The underlying mechanisms that regulate the indole pulse phenotype have not been fully characterised. Pulse signalling is thought to be linked to the increased expression of tryptophanase during the transition from exponential to stationary phase. Nonetheless, …
-
Regulatory mechanisms of epithelial sodium channel
… molecular biology approaches to investigate the mechanisms underlying the regulation of ENaCs by lipid metabolites, oxygen and mechanical stress. We have identified profound regulation mechanisms of ENaC in distal renal epithelial cells and vascular endothelial cells by lipid metabolites, heme …
-
Transcriptional Regulatory Mechanisms of Ribosomal Protein Genes
… work also reveals the roles of other chromatin regulatory factors in controlling antisense transcription. Collectively, these results significantly advance our current understanding of the regulatory mechanisms of ribosomal protein genes’ expression and antisense transcription. The ribosome and …
-
REGULATORY MECHANISMS OF TRANSCRIPTION AND ASSOCIATED DNA REPAIR
Transcription is a crucial regulatory step in gene regulation modulated by several proteins. Any misregulation during transcription can lead to many diseases including cancer, neurodegenerative disorders and aging making it imperative to have a detailed mechanistic view of the process. Over the …
-
Regulatory Mechanisms of Mitotic Catastrophe Induced by Doxorubicin
… (or multinucleation) to understand the regulatory mechanisms of mitotic catastrophe in human colorectal carcinoma cells. MATERIALS AND METHODS: We used human hepatoma (Huh-7) and human hepatocellular carcinoma cell lines (SNU-354, -398, -449, and -475) to distinguish the mode of low …
-
ELUCIDATION OF REGULATORY MECHANISMS OF TRANSCRIPTION AND COUPLED mRNA EXPORT
… aims had been focused on understanding the regulatory mechanisms of mRNA export by an F-box protein, Mdm30. Two recent studies have implicated the role of ubiquitylation in mRNA export via HECT domain-containing E3 ligases like Tom1 and Rsp5. My work has revealed the role of an F-box protein …
-
CRISPR-based Transcriptional Activators for Dissecting Human Gene-Regulatory Mechanisms
Nuclease-inactivated CRISPR/Cas-based (dCas-based) systems have emerged as powerful technologies to reshape the human epigenome and gene expression synthetically. Despite the increasing adoption of these platforms, their relative potencies lack optimization, and their mechanistic differences are …
-
Understanding Actin Dynamics and Its Regulatory Mechanisms in Developing Stereocilia
Stereocilia, the actin-based protrusions of auditory hair cells, are essential for converting mechanical stimuli into electrical signals. Their formation and maintenance require tightly regulated actin dynamics, including elongation and widening through filamentous actin (F-actin) incorporation. …
-
Regulatory mechanisms of MYO6 motor domain activity and tail interactions
The myosin super family represent a diverse group of actin-based molecular motors, driven by ATP hydrolysis. They are fundamental for a multitude of cellular processes, ranging from muscle contraction to intracellular transport to tethering. Originating from an ancestral protein, myosins have …
-
Characterization of Regulatory Mechanisms in Mucosal Immunity by Systems Immunology
… towards innocuous antigens. Therefore, the regulatory component is key to preserve tissue homeostasis and a normal functioning of the system. Indeed, defective regulatory responses lead to the development of pathological conditions, including unresolved infections, and inflammatory diseases. …
-
OTULIN's Novel Regulatory Mechanisms in Genotoxic and Inflammatory NF-kB Signaling
<p>Triple negative breast cancer (TNBC) is aggressive but cannot be treated with hormone therapy or molecular therapy due to the lack of a target. Chemotherapy is a systemic treatment that works by attacking rapidly growing cells, which is initially more effective for TNBC patients than those …
-
Probing the regulatory mechanisms of the actomyosin system in motile cells
… body. The goal of this work was to study the regulatory mechanisms of the motile machinery by selecting a representative key player for each stage of the signaling process: the regulation of Arp2/3 activity by WASP (actin system), the role of cGMP in myosin II assembly (myosin system), and the …
-
Novel Small-RNA Mediated Gene Regulatory Mechanisms for Long-Term Memory
… bidirectional, small-RNA mediated gene regulatory mechanism during plasticity where miRNAs provide translational control and piRNAs provide long-lasting transcriptional control for the persistence of memory.
-
Sodium channel regulatory mechanisms : current fluctuation analysis on frog skin epithelium
… project examined the role of the cytoskeleton in regulatory mechanisms of the amiloride-sensitive Na⁺ channels in isolated frog skin epithelium. The epithelium from ventral frog skin is a model tissue which has proved significant in our understanding of the basic principles involved in water and …
-
Regulatory Mechanisms Controlling Expression of the Toll-Like Receptor 2 Subfamily
Therefore, this thesis describes three novel mechanisms controlling expression of TLR2 subfamily members---one acting at the level of transcriptional activation, another at the post-transcriptional level, and finally one that regulates the post-translational localization of the receptor. In chapter …
-
Computational methods for inferring regulatory mechanisms from sequence and expression variation
… even close to a complete understanding of the mechanisms how the genetic variants contribute to phenotypic variation. With the vast majority of the genetic variants from Genome-wide Association Study (GWAS) located on the non-coding region of human genome, it is crucial to understand the gene …
Page 1 of 22