Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Regulatory Genomics"”.
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Computational regulatory genomics : motifs, networks, and dynamics
… In this thesis, we utilize comparative genomics and other approaches to exploit large-scale experimental datasets and better understand the sequence elements and regulators responsible for regulatory programs. In particular, we develop new computational approaches to (1) predict the …
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Knowledge-Guided Machine Learning for Single-Cell Regulatory Genomics
Transcription factors (TFs) and cis-regulatory elements coordinate gene regulation, and single-cell sequencing now enables these programs to be studied at high resolution. However, single-cell RNA-seq and ATAC-seq data are sparse and high-dimensional, making it difficult for existing methods to …
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Transcriptional regulatory genomics: from mechanistic modeling to causal inference
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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Computational analysis of cis-regulatory mechanisms underlying cellular response to drug perturbations
… disparate subfields of biology: pharmacogenomics and regulatory genomics. The former concentrates on how inherited factors such as SNPs and genes inform the response to medical interventions designed to ameliorate disease states, processes, and phenotypes; ontologically, it resides at the …
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Understanding the functional consequences of genetic variation on gene regulation
… gene expression is one of fundamental goals of regulatory genomics. Perturbing certain locations in the non-coding DNA causes a disturbance to the precise spatial and temporal expression of the genes. Gene regulatory mechanisms determine the amount of change in the gene expression from …
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Quantifying the functional and evolutionary relationships among sequences, transcription factor binding and gene expression
A central challenge in regulatory genomics today is to understand the precise relationship between regulatory sequences, transcription factor (TF) binding and gene expression. Many studies have discussed how TFs recognize their DNA binding sites. However, it is not well understood how the various …