Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Regulatory B cells"”.
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Investigating the antibody-independent functions of B lymphocytes
B cells are critical for the generation of antibody, but there is increasing evidence that they have a broader functional remit: For example, innate B1a cells are a critical source of granulocyte macrophage colony-stimulating factor (GM-CSF) during Gram-negative sepsis, inducing neutrophil …
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The role of B cells in the amplification and in the regulation of transplant rejection.
B cells are known to contribute to and/or influence immune response trough a<br/>variety of mechanisms. Regulatory B cells (Bregs) have recently discovered and<br/>their role in regulating autoimmune diseases has been demonstrated in different<br/>murine models. In the context of transplantation B …
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Biological effects of synthetic biomolecules that may either mimic or antagonise the function of hCG in the development of cancer and autoimmune disease
… antigens. It achieves this by expanding immunoregulatory cells such as tolerogenic dendritic cells, regulatory T cells (Tregs), and regulatory B cells (Bregs). Interestingly, hCG is also secreted by certain tumours, helping them evade immune detection by creating a tolerogenic environment. This …
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Engineering B Cells For Use In Immunotherapy and Cancer
<p>B cells can be divided into effector and regulatory immune cells. While effector B cells are key drivers of humoral immunity due to their ability to generate antibodies specific to pathogens, regulatory B cells (Bregs) have recently been shown to control inflammatory responses in multiple …
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The relationship between S. aureus biofilm properties, inflammation, and disease severity in chronic rhinosinusitis
… to the frequency and localisation of key immune cells in corresponding sinonasal mucosa and CRS severity scores. Here, we first found increased S. aureus biofilm metabolic activity, biomass, and exoprotein production in relation to increased disease severity scores with infiltration of …
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Regulatory Immune Responses and Repair Mechanisms in Atherosclerosis
… This thesis contains studies focusing on both regulatory immune responses and tissue repair mechanisms in experimental models of atherosclerosis as well as in patient cohorts. The first part of this thesis investigates the role of regulatory immune responses targeting plaque-related antigens. …
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Programmed cell death-ligand 1 (PD-L1) expression in HIV-associated diffuse large B-cell lymphoma – role and regulation
… signalling pathway is an important immunoregulatory mechanism that dampens the immune response by inhibiting T cell activity, playing a central role in controlling and maintaining tolerance to self-antigens. However, cancer cells have hijacked this mechanism by overexpressing PD-L1 to …