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Showing 1 to 12 of 12 for “"Regulator of g-protein signaling"”.
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RGS2 Modulation of Dopamine D2 Receptor Trafficking in Neuroblastoma Cells
… function is implicated in the pathophysiology of many diseases including Parkinson’s disease, schizophrenia, and drug addiction. D2R trafficking is vital to proper D2R function. While the expression and activity of D2Rs are altered in the pathology of these diseases, the underlying mechanisms …
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Primary characterization of genes involved in the colony development of the insect pathogenic fungus Metarhizium anisopliae /
Strain improvement of the insect pathogenic fungus Metarhizium anisopUae is necessary to increase its virulence towards agricultural pests and thus improve its commercial efficacy. Nevertheless, the release of genetically modified conidia in crop fields may negatively affect the ecosystem. …
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Genetic Dissection of Heart Development in the Fruit Fly Drosophila Melanogaster
… tube-like organ containing an inner layer of contractile cardial cells that adhere tightly to an adjacent layer of pericardial cells. A genetic screen for genes that control Drosophila heart development revealed a cardiac defect in which pericardial and cardial cells dissociate causing loss …
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Mechanistic and Engineering Studies of LOV Photoreceptors in Yeast
<p>A variety of cellular biosensors have evolved which can translate electromagnetic radiation from the environment into biological functions. Light-Oxygen-Voltage (LOV) domains in particular, are a group of photoreceptors that respond to blue wavelengths of light and can become a cellular …
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Bioinformatics Discovery And Functional Characterization Of Lipid-Binding Lov Photoreceptors
… sensitive (LOV) domain subset of the PAS superfamily is a ubiquitous photoreceptor class that enables organisms across multiple kingdoms to sense blue light. LOV photoreceptors are modular flavin-binding proteins that consist of discrete sensor and effector domains. Blue-light …
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From Cell Shape to Body Shape: Epithelial Morphogenesis in Drosophila melanogaster
… is associated with extensive rearrangements of tissues. The driving force for these rearrangements is generated by a dynamic reorganization of the Actin cytoskeleton of individual cells. In many instances, conserved Rho-family GTPases that are activated by Rho guanine nucleotide exchange …
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The Role of Vav-1, Vav-2 and Lsc in NK T cell development and NK cell cytotoxicity
… Rho-family GTP exchange factor (GEF) Vav-1 is a regulator of lymphocyte antigen receptor signaling and mediates normal maturation and activation of B and T cells. Recent findings suggest that Vav-1 also forms part of signaling pathways required for natural and antibody dependent cellular …
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In Pursuit of a Molecular Fountain of Youth: The Identification and Characterization of Lifespan Regulators in Drosophila
… has experienced steady increase despite lack of substantial intervention or understanding of the aging process. In fact, many organisms have the latent potential to live much longer than they normally do. This indicates lifespan determination is an active process subject to regulation. …
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Rhodopsin kinase structure: different nucleotide-binding states and implications for mechanism of activation of a G protein coupled receptor kinase
G protein coupled receptor (GPCR) kinases (GRKs) phosphorylate activated heptahelical receptors, leading to their uncoupling from G proteins and downregulation. The desensitization of GPCRs is critical to render cells responsive to further stimuli and if not regulated can result in many …
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Characterization of the Role of R7-RGS Proteins in Mammalian Retina and Vision
<p>ABSTRACT OF THE DISSERTATION</p><p>Characterization of the Role of RGS7-family Proteins in Mammalian Retina and Vision</p><p>by</p><p>Matthew David Cain</p><p>Doctor of Philosophy in Biology and Biomedical Sciences</p><p>Molecular Cell Biology</p><p>Washington University in St. Louis, …
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Untersuchungen zur dynamischen Regulation der Interaktion von RGS7 mit dem Adapterprotein 14-3-3
Das System aus G-Protein gekoppeltem Rezeptor, heterotrimerem G-Proteinkomplex und seinen Effektoren nimmt eine entscheidende Rolle in der Weiterleitung von Signalen in allen höheren Lebewesen ein. Lange stellte sich die Frage, wie die insuffiziente Inaktivierung dieses Systems in vitro und in vivo …
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Regulation der Genexpression und Promotoraktivität von RGS4 durch Leptin
… (Jaks) phosphorylate transcription factors of the STAT-family (signal transducers and activators of transcription), which then dimerize and translocate to the cell nucleus where they regulate gene expression. This Jak/STAT pathway is also activated by the cytokines interferon g (IFN-g) and …