Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 212 for “"Regulation of Gene Expression"”.
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Regulation of Gene Expression in Trypanosoma brucei
… protozoan parasite Trypanosoma brucei is one of the most divergent well-studied eukaryotes and many discoveries of general interest have been made in T. brucei. Atypical for a eukaryote, in T. brucei genes transcribed by RNA polymerase II (RNA pol II) are arranged in polycistronic …
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Estrogen Receptor Ligands and Regulation of Gene Expression
Keratin13 (KRT13) and calcitonin receptor (CALCR) gene expression is differentially regulated by estradiol (E2) and the selective estrogen receptor modulators (SERMs) tamoxifen and raloxifene. KRT13 is a cytoskeleton protein while CALCR mediates the biological effects of calcitonin. These two genes …
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Regulation of gene expression in macrophage immune response
Gene expression quantitative trait loci (eQTL) mapping studies can provide mechanistic insights into the functions of disease-associated variants. However, many eQTLs are cell type and context specific. This is particularly relevant for immune cells, whose cellular function and behaviour can be …
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Iron-dependent regulation of gene expression in Corynebacterium pseudotuberculosis
… encountered within its natural host. The impact of the availability of iron within the growth environment of numerous bacteria has been widely reported, and an equivalent investigation was conducted to determine whether the same was true of C. pseudotuberculosis. To this end, a novel …
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Bioinformatics approaches to analysing RNA mediated regulation of gene expression
… the blueprint for an organism. Composed of DNA, it harbours all organism-specific instructions for the synthesis of all structural components and their associated functions. The role of carriers of actual molecular structure and functions was believed to be exclusively assumed by proteins …
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Negative regulation of gene expression by the tumor suppressor p53
The tumor suppressor p53 inhibits the expression of a substantial number of genes whose protein products serve to promote cell survival or cell cycle progression, thereby ensuring efficient execution of p53-dependent apoptosis, cell-cycle arrest or senescence. Furthermore, p53-mediated repression …
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Regulation of gene expression and adhesion in <i>Saccharomyces cerevisiae</i>
… einen wichtigen Faktor bei der Virulenz pathogener Pilze dar. In dem Modellorganismus Saccharomyces cerevisiae ist die Adhäsion an Substraten oder an anderen Zellen abhängig vom Nährstoffangebot und Bestandteil komplexer Entwicklungsprozesse, wie dem haploiden invasiven Wachstum oder der …
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Specificity and mechanism of microRNAs in the regulation of gene expression
Originally thought of as a molecular inferior to its nucleic acid cousin DNA, RNA has more recently been appreciated as an equal partner in biology, a molecule at the heart of many crucial cellular reactions and perhaps the first molecule of life itself. The discovery of RNA interference (RNAi) has …
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Regulation of gene expression and cell state in embryonic stem cells
… and maintained through the combined action of transcription factors, chromatin regulators and signaling pathways, which all contribute to a transcriptional regulatory circuitry. Embryonic stem (ES) cells are capable of self-renewal and can give rise to nearly all differentiated cell-types, …
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Regulation of Gene Expression by Non-coding RNAs in Arabidopsis and Brachypodium
Expansion of high-throughput sequencing technology has increased our understanding in the importance of pervasive transcription and the resulting indispensable molecules, noncoding RNAs (ncRNAs). A significant effort has been made in determining the biological relevance of ncRNAs, including the …
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Dewdrops on the genome : regulation of gene expression by biomolecular phase separation
… physiology depend on the coordinated function of thousands of cell types - for example, neurons, immune cells, and skin cells. Each cell-type contains an identical copy of the genetic material yet performs specialized and diverse functions, in large part, due to the selective expression of …
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SYSTEMIC AND TRANSGENERATIONAL REGULATION OF GENE EXPRESSION BY SMALL RNAS IN C. ELEGANS
Development of an organism requires information contained minimally within a single cell. This information is inherited in two forms- the genome sequence and regulatory molecules. Little is understood about the types of the regulatory molecules inherited or the impact of parental experiences on …
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Investigations into the molecular regulation of gene expression in airway smooth muscle cells
The phenotype of airway smooth muscle (ASM) differs in asthmatic patients compared to healthy individuals. Hyperplasia, hypertrophy, increased contraction and altered synthetic capabilities of asthmatic airway smooth muscle cells (ASMCs) have all been reported, however, the molecular mechanisms …
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OMICs based identification of the mechanisms that underpin FAK’s regulation of gene expression
… cancer that is well known to be a key regulator of cancer cell proliferation, survival, migration and invasion. It has recently been shown to modulate the antitumour immune response via transcriptional regulation of chemokines and cytokines. These findings have fuelled interest in FAK as a …
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Epigenetic regulation of gene expression by BRD4 in cancer and innate immune response
Epigenetic regulation of gene expression plays essential roles in controlling normal cellular functions as well as abnormal cellular activities in human diseases like inflammatory diseases and cancers. The bromodomain-containing protein 4 (BRD4), one of the BET (bromodomain and extra terminal) …
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An Imaging Approach to Examine Telomere Dynamics and Regulation of Gene Expression with Aging
… nucleotide sequences (TTAGGG)n capping the ends of chromosomes. Improved methods to measure the shortest (not just average) telomere lengths (TLs) are needed. Progressive telomere shortening with increasing age has been associated with shifts in gene expression through models such as the telomere …
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Ethylene response and phytohormone-mediated regulation of gene expression in Komagataeibacter xylinus ATCC 53582
… This thesis elaborates on the ecophysiology of K. xylinus. Responses to indole-3-acetic acid (IAA), abscisic acid (ABA) and ethylene, produced in situ from ethephon, were of particular focus. The effect of these phytohormones on K. xylinus cellulose production and expression of cellulose …
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Computational Approaches to Predict Effect of Epigenetic Modifications on Transcriptional Regulation of Gene Expression
This dissertation presents applications of machine learning and statistical approaches to infer protein-DNA bindings in the presence of epigenetic modifications. Epigenetic modifications are alterations to the DNA resulting in gene expression regulation where the structure of the DNA remains …
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The role of DNA supercoiling in the coordinated regulation of gene expression in Helicobacter pylori
Summary Mechanisms of global gene regulation in bacteria are not well characterized yet. Changes in global or local supercoiling of chromosomal DNA are thought to play a role in global gene silencing and gene activation. In Helicobacter pylori, a bacterium with few dedicated transcriptional …
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