Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Regulated secretion"”.
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New stimulators and a new mechanism of regulated secretion in pituitary gonadotropes
… LH; and follicle-stimulating hormone, FSH) secretion is the peptide gonadotropin-releasing hormone (GnRH). It acts via a rise in intracellular Ca$\sp{2+}$ concentration ( (Ca$\sp{2+}\rbrack\sb{\rm i}$). I used cultured pituitary gonadotropes of male rats to seek other possible agents and …
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Structure and Function of Proteins Involved in Regulated Secretion: Synaptotagmins and Complexin
… of neurotransmitter from neurons is a tightly regulated process. There are a number of proteins required for membrane fusion to occur, and then there are regulatory proteins that allow membrane fusion to proceed at incredible speed with the precise timing necessary for complex functions such as …
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LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF POST-TRANSLATIONAL MODIFICATIONS TO HMGB1 AND ITS REGULATED SECRETION IN LUNG CANCER
… HMGB1. Cisplatin, but not carboplatin, induced secretion of HMGB1 from human non-small cell lung cancer (NSCLC) A549 cells in a necrosis-independent mechanism. Cisplatin-mediated HMGB1 secretion was dose-dependent and was regulated by nuclear exportin 1 (XPO1) also known as chromosomal …
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A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion
… a transmembrane (tm) sequence, and constitutive secretion was overcome by incorporating a tyrosine-base cytosolic sorting signal (Y) taken from CD63. This signal directed sTNFR1-tm-Y from the trans-Golgi network (TGN) to secretory lysosomes, followed by generation of membrane-free soluble sTNFR1. …
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Sorting of Cargo Proteins Within the Regulated Secretory Pathway: the Peripheral Membrane Protein HID-1 as a Sorting and Vesicle Biogenesis Factor
… at the trans-Golgi network (TGN) and mediate the regulated release of neuropeptides and peptide hormones. Despite their central role to physiology, the mechanisms controlling biogenesis and sorting to LDCVs is not well understood. Optimizing the retention using selective hooks (RUSH) method in …
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Notch Regulates Vascular Collagen IV Basement Membrane Through Modulation of Lysyl Hydroxylase 3 Trafficking
… the intracellular transport and selective secretion of Col IV in response to angiogenic cues, leaving a void in our understanding of this process. Our aim was to identify trafficking pathways that regulate Col IV deposition during angiogenic blood vessel development. We have identified the …
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Vesicle-associated Membrane Proteins in Airway Mucin Secretion
… mucin production and hydration, the process of secretion is not yet fully comprehended.</p> <p>Mucin undergoes regulated secretion at two rates: a low baseline rate and a high stimulated rate. Over the past 25 years, our lab has discovered and defined that these two rates involve distinct …
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Mechanisms for Targeting of Proteins to Secretory Lysosomes of Haematopoietic Cells
… neutrophil granules for subsequent release by regulated secretion in an inflammatory process. However, the granule content is very potent and may cause tissue damage when released. Basic knowledge about biosynthesis, targeting and secretion of these proteins is therefore important for the …
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Novel Roles of PACS-1 Within the Nucleus and the Regulated Secretory Pathway
… of membrane protein trafficking within the regulated secretory pathway. First, our results establish PACS-1 motifs that regulate nuclear localization through the classical nuclear trafficking pathway. Moreover, we have identified a novel interaction between PACS-1 and the nucleocytoplasmic …
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REGENERATION OF ELECTROSPUN BIORESORBABLE VASCULAR GRAFTS: A PHENOMENON ASSOCIATED WITH VASCULAR GRAFT PROPERTIES AND MACROPHAGE PHENOTYPES (M1/M2)
… by the process of degranulation; the process of regulated secretion in which preformed contents stored in their granules are rapidly released by exocytosis. Some of these cytokines such as IL-4, IL-13 and TNF-α can modulate the MФ phenotype. Macrophages (MΦ) are innate immune cells, crucial for …