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Showing 1 to 1 of 1 for “"Regioisomeric replacements"”.
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Pyrrolo[2,3-d]pyrimidine Classical Antifolates for Targeted Cancer Chemotherapy- Applications of Bioisosteric and Regioisomeric Substitutions for Improved Tumor-Selectivity and Potency
… dissertation discusses the bioisosteric and regioisomeric optimization of 5-and/or 6-substituted pyrrolo[2,3-<em>d</em>]pyrimidine antifolates for improved tumor-targeted activity. Molecular modeling with the help of known X-ray crystal structures of the transporters and the intracellular …