Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Reference gene"”.
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A Functional Analysis of microRNAs in Nicotiana tabacum
… class of endogenous post-transcriptional gene regulators that are typically 20-22 nucleotides in length that do not code for proteins. MiRNAs regulate gene expression by either inhibiting protein translation, or by targeting messenger RNAs (mRNAs) for cleavage. MiRNAs are highly …
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An evaluation of genetic markers for forensic identification of human body fluids
… fluids, and are prone to contamination. Various genes are expressed in different body fluids that could be used as genetic markers for body fluid identification, and are used in forensic investigations. The aim of this study was to use mRNA markers to identify human body fluids, which included …
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Quantitative Real-Time PCR Analysis of Colchicine Pathway and Rhizome Developmental Genes
… of G. superba sequences have identified putative genes potentially involved in the colchicine biosynthesis pathway and rhizome development, respectively. Using quantitative real-time polymerase chain reaction (qRT-PCR), a comparative analysis of gene expression in G. superba may reveal …
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Equine Trophectoderm Cells and Their Role in Fetal-Maternal Recognition
… changes in cell proliferation and expression of genes likely involved in maternal recognition. The objectives of this experiment were to evaluate the effect of these GFs on iTr mitotic response and regulation of genes involved in steroidogenesis. Equine iTr cells (n = 3) were cultured with 10 …
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Three Generations, One Future: A Systematic Analysis on Nicotine's Effect across generations in C. elegans.
… but are also inherited to the subsequent generations. With respect to nicotine, a wealth of studies have investigated the dose and time-dependent effects of this chemical on multiple systems including cell lines and model organisms. However, the transgenerational effect of nicotine exposed …
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The Role of Lysophosphatidylcholine Acyltransferase (LPCAT) 3 in Macrophage Inflammatory Responses
… bacteria, are key factors in the pathogenesis of sepsis. The activation of macrophages with LPS results in rapid changes in the expression of genes encoding cytokines and other inflammatory mediators. The excessive, prolonged and unregulated activation of macrophages in sepsis leads to …
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Towards Mammalian Retinal Regeneration: Cell Signaling in Re-Differentiating Mouse Müller Glia and Transcriptional Regulation of the Axonal Guidance Receptor EPHA5
… blindness because the mammalian retina cannot regenerate. For stem cell therapies to regenerate a functional retina, multiple challenges must be overcome. These include identification of stem cell sources, targeted differentiation into particular retinal neuronal cell types, delivery to the …
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Efficient gene set analysis of high-throughput data : From omics to pathway architecture of health and disease
… different species are caused by alterations in gene regulation. The study of gene expression is thus crucial for understanding both normal physiology and disease mechanisms. High-throughput mea- surement technologies allow the profiling of tens of thousands of genes simultaneously. However, the …
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Thyroid hormone action and disruption in the brain: Xenopus as a model to study disruption of thyroid hormone availability on early brain development
… Disruption of TH action, either due to genetic and/or environmental factors, has been implicated in neurological defects such as autism, attention deficit hyperactivity disorders (ADHD) and IQ loss. On average, over 30 anthropogenic chemicals are present in all American women, with 15 …
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Host Cytokines and Immune Responses in Pregnancy Associated Transmission of Arrested Hookworm Larvae
Over one billion people worldwide are infected with blood-feeding intestinal hookworms. The life cycle of A. duodenale (humans) and A. caninum (dogs) includes the propensity for L3 to undergo a temporary state of developmental arrest in the host. In female hosts, tissue-arrested L3 reactivate …
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Heat stress: A risk factor for skin carcinogenesis
… (UV) is a major risk factor for skin carcinogenesis. UV, particularly the UVB spectrum, causes formation of cyclobutane pyrimidine dimers (CPD) in cellular DNA. Persistent and incorrectly repaired CPDs lead to DNA mutations and consequently, formation of cutaneous lesions. Interestingly, …