Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Reexpression"”.
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Charakterisierung der Funktion des Tight Junction Proteins hu-CLDN1 und seine Bedeutung bei der Tumorgenese
… Tumoren- und Normalgewebe untersucht. Für die Reexpression von hu-CLDN1 in Brusttumorzellen wurden retrovirale Genshuttlesysteme hergestellt. Die retroviralen Genshuttlesysteme basieren auf dem MoMuLV Grundgerüst und als Besonderheit wurde der l-NGFR Rezeptor zur schnellen und sicheren …
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Aberrante DNA-Methylierung des Transkriptionsfaktors C/EBP[alpha] bei akuter myeloischer Leukämie
… demethylating agent DAC resulted in C/EBP alpha reexpression and promotor demethylation. C/EBP alpha has been shown to regulate cell cycle progression through inhibition of cyclin-dependent-kinase (CDK) 2 and 4. Therefore we investigated a possible relationship between the methylation patterns of …
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Therapie der Spondylitis ankylosans mit dem monoklonalen chimären anti-TNF-Antikörper Infliximab (Remicade®):Klinische Wirksamkeit und Einfluss auf die HLA-Oberflächenexpression auf Lymphozyten mit besonderer Berücksichtigung von HLA-B27
… erhöhten Zelldepletion assoziiert. Durch die Reexpression trimolekularer HLA-B27-Moleküle wird die Interaktion zwischen immunkompetenten Zellen und HLA-B27-positiven Zellen beeinflusst, wodurch das Zellüberleben begünstigt wird. Dieser Erklärungsansatz ist vereinbar mit dem gegenwärtig …
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Zur epigenetischen Inaktivierung der Wnt-Antagonisten SFRP-1, -2, -4 und -5 bei der Akuten Myeloischen Leukämie
… agent 5-aza-2’deoxycytidine led to a reexpression of SFRP-1 and SFRP-2 in real-time RT-PCR analysis. By MSP, we analyzed the methylation status of SFRP-1,-2,-4 and -5 in 97 specimens obtained from AML patients at diagnosis. The frequencies of aberrant methylation among the primary …
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Axon Degeneration and the Schwann Cell Early Injury Response: A Study in Mouse and Zebrafish
… is normal. I then performed cell specific reexpression experiments with human SARM1 and show that neuronal SARM1 is sufficient to rescue axon degeneration. In a more traditional mouse model of peripheral nervous system injury, I performed a bulk RNA sequencing study of the distal tibial …
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When good synapses go bad: dendritic spine dysgenesis in a mouse model of Fragile X mental retardation
… adeno-associated viral vector (rAAV) to induce reexpression of FMRP in the brain. Analysis by Golgi staining showed that expression of FMRP altered the spine phenotype towards a profile resembling the phenotype in WT animals injected with control vector. Together, these findings support a …
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Diet in the promotion or prevention of colorectal cancer
… showing increase in apoptosis, and effects on reexpression of MLH1 protein levels by western blot. We also tested a few natural compounds with the model and found that EGCG, which is well-known that it has demethylating ability, induced similar levels of DNA damage as 5-azacitidine, suggesting …
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Moesin in Thrombozyten interagiert mit PECAM-1 : Bedeutung für die Atherosklerose und Restenose
Moesin is a member of the Ezrin/Radixin/Moesin (ERM) protein family, which is located in cellular protrusions such as filopoda. Members of this family form a cross-link between the actin cytoskeleton and the plasma membrane. They participate in signal transduction between the extrecellular matrix, …