Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Reelin"”.
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Role of Reelin-Dab1 Signaling in the Neuritogenesis
Reelin is a secreted extracellular glycoprotein in the Cajal-Retzius cell that binds to the very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2), inducing tyrosine phosphorylation of Dab1, a cytoplasmic adaptor protein of receptors. The Reelin-Dab1 signaling is …
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The crucial role of reelin in a preclinical model of depression
… CORT treated rats have shown a downregulation in reelin. Reelin is a large glycoprotein that has been implicated in many psychiatric illnesses. Reelin is involved in stimulating the growth of dendrites, guiding neuronal migration, and regulating synaptogenesis. The goal of these experiments was to …
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Examining Hippocampal Reelin Expression and Neural Plasticity in an Animal Model of Depression
… one candidate molecule of particular interest is reelin, an extracellular matrix protein responsible for regulating neuronal maturation and synaptic plasticity in the adult brain. Interestingly, recent post- mortem analyses indicate that reelin expression is decreased in depressed patients. …
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Cell death of reelin secreting nNOS positive GABAergic interneurons in the hippocampus of P301L trangenic mice
Reelin은 세포외 기질 당단백질로서 초기 뇌의 발달 과정에서 신경세포의 이동에 있어서 중요한 역할을 한다. 또한, 성인 뇌의 겉질과 해마에 있는 GABA성 신경세포에서 발현하여 시냅스 가소성과 기억을 조절한다. Reelin을 발현하는 GABA성 신경세포의 subtype들 중에서 해마에서는 neuronal nitric oxide synthases (nNOS)를 발현하는 GABA성 신경세포가 가장 높은 비율로 존재하고 있다. 이러한 GABA성 신경세포의 생존에 있어서 Tau의 인산화가 중요한 역할을 담당하고 있으며, 그렇기 때문에 …
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Amelioration of Alzheimer's Disease Pathology in 12-Month-Old hAPP(SweInd) Transgenic Mice After Treatment with a Cysteine Rich Whey Supplement, Immunocal®
<p>Deficits in Reelin expression and signaling play a pathogenic role in Alzheimer’s disease (AD). Thus, strategies aimed at correcting Reelin deficits may provide a novel therapeutic approach to treating AD. The cysteine-rich, whey protein supplement, Immunocal®, has recently been shown to rescue …
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Expression of Apolipoprotein E Receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR), Reelin Receptors in Development of Cerebellar Cortex
During brain development, reelin, an extracellular matrix protein regulates neuronal migration in the cerebral cortex, hippocampus, cerebellum and many other regions of mammalian brain. In the cortex, reelin is secreted by cajal-Retzius cells in the developing marginal zone and is required for …
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Fas-associated factor 1 is involved in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice
… 30 PART II 31 ABSTRACT 32 Ⅰ. INTRODUCTION 34 A. Reelin expression in GABAergic neurons 34 B. Reelin structure 36 C. Reelin fragments 38 D. Reelin receptors and reelin signaling 39 E. The involvement of Reelin signaling in neuropsychiatric disorders 41 F. Astrogliosis 41 Ⅱ. MATERIALS AND METHODS …
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Regulatory Role of ApoE and Apoer2 in Synaptic Activity: A New Insight into Alzheimer's Disease
… (SFKs) upon binding to the extracellular ligand Reelin. Here, we show that this Reelin-Apoer2-Dab1-SFKs signaling complex greatly enhances the tyrosine phosphorylation as well as the calcium conductance of NMDA receptor, a calcium-permeable postsynaptic glutamate receptor that is critical for …
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Vergleichende Untersuchung des Reelinsignalweges bei Wildtyp- und Presenilin-1-Knockoutmäusen während der embryonalen Hirnentwicklung
… Lissenzephalie Typ 2. Es ist bekannt, dass die Reelinexpression in Presenilin-1-Knockoutmäusen vermindert ist. In dieser Arbeit wurde untersucht, ob der Reelin-Dab1-Signaltransduktionsweg ebenfalls beeinflusst ist. Dazu wurden die Veränderungen der cortikalen Reelin- und Dab1- Expression im …
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ApoE Receptors in Alzheimer's and CNS Function
… to the neuromodulator and ApoE receptor ligand Reelin, which enhances synaptic plasticity and protects against amyloid β (Aβ) oligomer-induced synaptic toxicity in vitro. Here, mice with reduced Reelin expression were more sensitive to amyloid-induced synaptic suppression, and had memory and …
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Characterization of subtypes of precursor cells in the developing central nervous system
… show that radial morphology is impaired in the Reelin-deficient cerebral cortex of the reeler mouse correlated to a decrease in the content of BLBP in radial glial cells. These defects were restricted to the cerebral cortex, but did not occur in the basal ganglia that exhibit normal migration …
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The identification of candidate genes using cDNA microarray and the analysis of two SNPs of the reelin gene in a South African austistic population
… brain functioning. Studies have identified the reelin (RELN) gene as necessary for proper formation of brain, which indicates that RELN abnormalities could contribute to the aetiology of several neurogenetic diseases such as schizophrenia, bipolar and autism. The aims of the study were (i) to …
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Targeting Ion Channels to Distal Dendrites
… evidence that the extracellular matrix protein reelin acts as this non-cell autonomous factor regulating ion channel composition of the distal dendrites. Blocking reelin signaling in organotypic culture results in reduction of HCN1 in the dendrites and distal HCN1 levels are reduced in reeler …
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Regulation and Function of Apoer2 and Vidlr in the Central Nervous and Reproductive Systems
… similar receptors and are both involved in the Reelin signaling pathway. This pathway controls neuronal migration and organization of the brain during development as well as synaptic function in adulthood. Although both receptors partially compensate for one another during Reelin signaling, the …
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Identifizierung differentiell exprimierter Gene mit potentiellem Einfluß auf die Entwicklung transitionaler B-Zellen zu reifen B-Zellen der Milz
… befindet sich das Transkript für Reelin. Die Expressionsstudien zeigen, daß Reelin in den frühen B-Zell-Stadien des Knochenmarks und in T1 B-Zellen um mehr als zehnfach höher transkribiert vorliegt als in reifen B-Zellen. Die durchgeführten durchflußzytometrischen Untersuchungen …
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Hitzeschockproteine in neuralen Zellen: entwicklungsabhängige Expression und differentielle Regulation nach Stress
… an der Hirnentwicklung beteiligte ECM-Protein Reelin für die normale Differenzierung von Neuronen in vitro nicht notwendig war. Zudem wurde nachgewiesen, dass sich Neurone und Gliazellen in Kultur in ihrer Stressantwort unterschieden. Astrozyten wiesen sowohl konstitutiv wie auch nach Stress …
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The roles of the Robo2 and Robo3 receptors in the development of cortical interneurons and Cajal-Retzius cells
… has a role in determining the total numbers of (reelin immunopositive) Cajal-Retzius cells within the hippocampal cortex.
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Characterisation of genetic and epigenetic aberrations in paediatric high grade glioma
… BRAFV600E in 1/17 (6%) case. Genes involved in reelin/PI3K signaling (DAB1), RTK signaling (PTPRE), and arginine biosynthesis (ASS1 and ASL) were frequently deregulated by methylation in these tumours. The anti-growth and anti-migratory properties of DAB1 and PTPRE were demonstrated in vitro. …
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Novel Therapeutic Targets Identified By High-Throughput Technologies For Triple-Negative Breast Cancer
… (VLDLR). Exposure to their cognate ligands, reelin and apolipoprotein E isoform 4 (ApoE4), stimulated the growth of TNBC cells in vitro. Suppression of the expression of either LRP8 or VLDLR or exposure to RAP (an inhibitor of ligand binding to LRP8 and VLDLR) abolished this ligand-induced …
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Die Körnerzellposition beeinflusst die Faserschichtung der Fascia dentata der Maus : eine Studie an Reeler, Apolipoprotein E Receptor 2 defizienten und Very Low Density Lipoprotein Receptor defizienten Mäusen
Die Aufklärung von Entwicklungsprozessen, die zu spezifischen Verbindungen zwischen Nervenzellen führen, ist ein fundamentales Ziel der modernen Entwicklungsneurobiologie. Für diese Untersuchungen ist die Fascia dentata der Hippokampusformation aufgrund ihrer überschaubaren Struktur und …