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Showing 1 to 13 of 13 for “"Reductive Cyclization"”.
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SYNTHESIS OF N-HETEROCYCLES VIA PALLADIUM-CATALYZED REDUCTIVE CYCLIZATION REACTIONS OF NITROARENES AND NITROALKENES USING FORMIC ACID DERIVATIVES AS CO SURROGATES
The reductive cyclization reaction of nitroarenes to produce N-heterocycles has been investigated for more than four decades using CO as a cheap reductant, but it is still a fascinating area for research and advancements. On the other hand, using toxic CO gas is accompanied by many …
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Studies directed towards the total synthesis of (+)-sieboldine A
… approach uses a nickel-catalyzed alkyne-ketone reductive cyclization to form the hydrindane core of the natural product in good yield and with excellent diastereoselectivity about the newly formed tertiary allylic alcohol ... The hydrindane product from this reductive cyclization can be …
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I The tandem chain extension-acylation reaction II Synthesis of papyracillic acid A: Application of the tandem homologation-acylation reaction III Synthesis of tetrahydrofuran-based peptidomimetics
… chain extension-aldol reaction, followed by a reductive cyclization, allowed for the synthesis of tetrahydrofuran-based peptidomimetics. A variety of amino acid derived beta-keto imides and aldehydes were used during the initial tandem homologation-aldol reaction. High diastereocontrol was …
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Cross-Coupling Chemistry as a Tool for the Synthesis of Diverse Heterocyclic Systems and Natural Products
… o-Halonitroarenes or o-Iodobenzonitriles and Reductive Cyclization of the Resulting Products To Give Diverse Heterocyclic Systems'. The third publication has the title 'Reductive Cyclization of o-Nitroarylated-alpha,beta-Unsaturated Aldehydes and Ketones with TiCl3/HCl or Fe/HCl Leading to …
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Cross-Coupling Chemistry as a Tool for the Synthesis of Diverse Heterocyclic Systems and Natural Products
… o-Halonitroarenes or o-Iodobenzonitriles and Reductive Cyclization of the Resulting Products To Give Diverse Heterocyclic Systems'. The third publication has the title 'Reductive Cyclization of o-Nitroarylated-alpha,beta-Unsaturated Aldehydes and Ketones with TiCl3/HCl or Fe/HCl Leading to …
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Studies on a catalytic cadogan cyclization by PI̳I̳I̳/PV̳=O redox cycling
… successfully adapted this concept to the Cadogan reductive cyclization by using a strained 4-membered phosphetane precatalyst, which proved to be more competent than acyclic and 5-membered analogs for P(III)/P(V)=O redox cycling. A variety of substrates were found to successfully undergo catalytic …
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PALLADIUM-BASED SYSTEMS IN HOMOGENEOUS CATALYSIS: EXPLORING NITROGEN LIGANDS FOR CO-MEDIATED REACTIONS
… of palladium-phenanthroline catalytic system in reductive cyclization of nitroarenes, the study investigates CO and its surrogates as reductant for the synthesis of different nitrogen-containing heterocycles. Furthemore, the use of guanidines as ligands in carbonylation and alkoxycarbonylation of …
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[4+2] cycloadditions of iminoacetonitriles : a general strategy for the synthesis of quinolizidines, indolizidines, and piperidines
… by stereoselective alkylation, reduction, reductive cyclization, and Bruylants reactions. The first part of this thesis describes the full details of our studies on the synthesis of iminoacetonitriles, the scope of their Diels-Alder reactions, and the synthetic elaboration of the a-amino …
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Studies toward the total syntheses of tamulamides A and B
… has been achieved through an intramolecular reductive cyclization reaction. With successful routes to the ABC and EFG cores in hand, current work is focused on elaboration of these intermediates to the desired Wittig coupling partners en route to the first total syntheses of tamulamides A and …
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Applications of titanium-mediated reductive coupling and cyclocarbonylation reactions toward natural product synthesis
… not only a synthetic value of tandem reductive cyclization - carbonylation reactions in the preparation of complex molecules but also the interesting stereoselectivity observed therein. The first part of this work employs the titanium-mediated cyclocarbonylation of tethered dienals for …
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Palladium -catalyzed synthesis of carbazole derivatives and formal total syntheses of several naturally occurring carbazole alkaloids
… Stille coupling followed by an intramolecular reductive N-heteroannulation. For example, 1,2-dihydro-4(3H)-carbazolone was prepared in good isolated yield (74%) by the reductive cyclization of 2-(2-nitrophenyl)-2-cyclohexen-1-one using Pd(dba)2 (6 mol%), 1,3-bis(diphenylphosphino)propane (6 …