Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Redox homeostasis"”.
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Redox Homeostasis in Cyanobacteria
… electron transfer chains comprised of redox active intermediates and light harvesting complexes. While oxygen is a necessary byproduct of water oxidation and the source of photosynthetic electrons, its presence is also dangerous because leakage of electrons and excitation energy can …
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Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
… insults, and this coincided with preserved thiol redox homeostasis and greater stability in mitochondrial bioenergetics. The maintenance of mitochondria thiol was demonstrated through preservation of glutathione, which is a key redox control point in cardiac bioenergetics. When the thiol pool …
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Disruption of mitochondrial redox homeostasis as a cellular signal.
… antioxidant systems to help maintain thiol homeostasis. Mitochondria are emerging as an important redox signalling node and are involved in a myriad of signalling pathways, which have a redox component, either through a response to a particular ROS or the shift of the redox state of a …
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Microenvironmental and metabolic influences in tumor cell redox homeostasis
Redox reactions dictate protein shape, regulate enzyme activity, and underscore cellular metabolism. When redox poise fails and cells are overcome by oxidation, cellular death soon follows. Redox biology is an especially important aspect of cancer cell biology, because oncogene-induced …
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Regulation of the redox homeostasis during polyglutamine misfolding in Huntington’s Disease
… oxidative stress. While several changes in the redox homeostasis have been shown to occur in HD animal models and HD brains, the formal relationships between intracellular protein misfolding that occurs in HD, redox dysregulation and cellular toxicity are unknown. Therefore, several cellular …
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REDOX HOMEOSTASIS IN THE DROSOPHILA TESTIS STEM CELL SELF-RENEWAL AND MAINTENANCE
… and aging. Here, I examined the effects of redox states on stem cell maintenance, and identified the downstream effectors of ROS that control stem cell behaviour, using the Drosophila testis germline stem cell (GSC) model. High ROS resulted in the activation of EGFR signaling, which …
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The Role of Oxygen and Oxygen-Dependent Enzymes in Protein Folding, Metabolism, and Redox Homeostasis
… elicit a metabolic imbalance leading to loss of redox homeostasis. Taken together, this thesis explores the role and the importance of oxygen and oxygen dependent enzymes that drive acute responses such as affecting the disulfide bond formation of protein folding and deregulation of the cancer …
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An Intermediate Heme Threshold is Necessary for the Activation of the Stress Response and Redox Homeostasis in Yeast
… activation of the stress response to maintain homeostasis. The activation of the stress response includes the expression of molecular heat shock proteins (HSPs) and the antioxidant defence system mediated by the transcription factors Msn2/4, Gis1 and Hsf1. Here, we reveal that an intermediate …
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The Current Role of Kynurenine Pathway Interventions in Oxidative Stress and Redox Homeostasis in the Context of Aging and Cancer
… in the kynurenine pathway have immunological and redox properties that have been associated with cancer initiation, progression, and metastasis. Increased flux of tryptophan metabolism towards the kynurenine pathway has been positively correlated with age and age-related diseases. The necessity of …
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The role of DAXX in the selective autophagy receptor SQSTM1/p62 phase condensation
… oxidative stress and maintaining the cellular redox homeostasis. To examine whether DAXX has an effect on redox homeostasis, Reactive Oxygen Species (ROS) assays and Dual-luciferase assays were applied, and results showed that the DAXX-induced p62 phase condensation promotes p62 recruitment of …
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SYNTHESIS OF SMALL MOLECULE PROBES FOR PROTEIN SULFENIC ACIDS
… and its metabolites participate in cellular redox homeostasis and have become well documented in recent years as messengers in signal transduction. One important mechanism by which redox-based signaling happens is reversible oxidation of cysteine residues forming cysteine sulfenic acids …
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Molecular Mechanisms of Programmed Necrotic Death Initiated by Intrinsic Death Signals
… death is critical for tissue development and homeostasis, with deregulation implicated in many illnesses. Cell death is morphologically categorised as apoptosis, autophagy, and necrosis, with apoptosis being the best studied. BCL-2 family members are critical apoptosis regulators. Death …
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HcpE, a potential immuno-modulatory protein from Helicobacter pylori that is dependent on the Disulfide bond protein DsbHP
… DsbG, and that DsbHP is involved in maintaining redox homeostasis in H. pylori.
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Genomic studies of oocyte physiology reveal mechanisms critical to oocyte competence
… focused on the genes that are related to redox homeostasis. Using same oocyte competence models (prepubertal versus adult, in vivo versus in vitro) we found that GLRX2, PDIA4, PDIA6 and TRXR1 may be functionally relevant to oocyte competence. By maturing oocytes in different redox …
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The Tca Cycle As A Nexus of Metabolic Vulnerabilities In Cancer
… demands of proliferation and fortify redox homeostasis. An increasing body of literature suggests that mitochondrial metabolism (tricarboxylic acid cycle (TCA) and oxidative phosphorylation) is imperative for cancer cell growth and proliferation. The scope of the works presented in …
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The expression profile of cytoglobin in human fibrotic lung, and the protective role of cytoglobin in hypoxia and oxidative stress in vitro
… CYGB is likely to have a role in oxygen and redox homeostasis.
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Unraveling Molecular Mechanisms Underlying the Development of Unconventional T Cells
… T cells have emerging roles in tissue homeostasis and disease, but the molecular mechanisms underpinning their development remain elusive. In this study, we uncovered the roles of the molecules RAPTOR and PTEN in the thymic development of unconventional T cells. Capitalizing on genetic …
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Transcriptomic study of evolution and gene expression in diploid and allotetraploid glycine subgenus glycine
… thaliana has been implicated in the mediation of redox homeostasis. Changes in distribution of this BolA4-like protein due to the 24-base-pair deletion in the soybean lineage would likely make this protein differently distributed in soybean compared to its perennial wild relatives. Whether the …
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Drug Discovery in Redox Biology: From Natural Products to Structural Biology
Redox-regulating systems play essential roles in maintaining cellular homeostasis and represent important therapeutic targets in cancer and infectious diseases. Natural products provide structurally diverse redox-active scaffolds capable of modulating oxidative stress and redox sensitive signaling …
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Development of Dual-Electrode Amperometric Detectors for Liquid Chromatography and Capillary Electrophoresis
… detection schemes were developed to investigate redox chemistries for endogenous and exogenous antioxidants that play key roles in maintaining tissue redox homeostasis under oxidative stress conditions. A parallel adjacent dual electrode detector was first proposed for liquid chromatography in …
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