Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Redox Biology"”.
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Redox biology of myeloid leukaemias
Internal tandem duplication of FMS-like receptor tyrosine kinase (FLT3-ITD) has been associated with an aggressive AML phenotype. FLT3-ITD expressing cell lines have been shown to generate increased levels of reactive oxygen species (ROS) and DNA double strand breaks (dsbs). However, the molecular …
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Redox biology in retinal degeneration
… for the first time the implication of redox biology in the Norgestrel-mediated neuroprotection against retinal degeneration.
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UNDERSTANDING SULFUR BASED REDOX BIOLOGY THROUGH ADVANCEMENTS IN CHEMICAL BIOLOGY
… formation is crucial to understanding cellular redox regulation.
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Drug Discovery in Redox Biology: From Natural Products to Structural Biology
Redox-regulating systems play essential roles in maintaining cellular homeostasis and represent important therapeutic targets in cancer and infectious diseases. Natural products provide structurally diverse redox-active scaffolds capable of modulating oxidative stress and redox sensitive signaling …
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Towards next-generation enzymatic generators of hydrogen peroxide in quantitative redox biology
… can be approximated by accounting for only peroxiredoxin as the sole H₂O₂ scavenger that does not become depleted by H₂O₂ oxidation. We thus reduced the model to a single equation, allowing us to use the finite Fourier Transform (FFT) method to develop an analytical transport model. This should …
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Applications of Engineered Proteins in Redox Biology and Biomarker Detection Assay Development
… primary respondent of cytosolic H₂O₂ is peroxiredoxin 1 and the H₂O₂ induced apoptosis initiates before the collapse of Prx/Trx/TR antioxidant network. Then, a genetically encoded FRET sensor was used to design a high-throughput screening assay that identified three small-molecule drugs from …
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AN INVESTIGATION OF THE REDOX REGULATION OF THE DEOXYNUCLEOTIDE TRIPHOSPHOHYDROLASE SAMHD1 AND ITS ROLE IN NUCLEOTIDE HOMEOSTASIS
… with regards to SAMHD1 regulation is redox biology. Redox biology is emerging as a central regulator in myriad cellular processes including cell cycle progression, cellular metabolism, and cell signaling. Given the role that nucleotide metabolism plays in these processes, this study …
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Methodologies for the mechanistic study of compartment-specific hydrogen peroxide perturbations
… will be more susceptible to toxicity via a redox-based mechanism than their surrounding healthy counterparts, and provides an attractive target for those studying redox biology. In order to effectively leverage this strategy, quantitative knowledge of intracellular ROS, specifically hydrogen …
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Interplay of Iron and Hydrogen Sulfide in Pathophysiology of Vascular Damage
… (H₂S) and iron are fundamental regulators of redox biology, exerting opposing influences on oxidative stress and vascular homeostasis, yet their mechanistic interplay remains unresolved. This dissertation addresses this gap through a series of studies spanning molecular, mitochondrial, …
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Development of Novel Molecular Imaging Contrast Agents for Detection of Oxidative Stress
… Our understanding of how ROS influence disease biology is currently limited by our inability to perform sensitive and specific assessment of ROS levels with high spatial and temporal resolution in living systems. The goal of the research described in this thesis was to overcome the challenge of …
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Microenvironmental and metabolic influences in tumor cell redox homeostasis
Redox reactions dictate protein shape, regulate enzyme activity, and underscore cellular metabolism. When redox poise fails and cells are overcome by oxidation, cellular death soon follows. Redox biology is an especially important aspect of cancer cell biology, because oncogene-induced …
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A quantitative analysis of chemotherapy-induced reactive oxidative species using genetically encoded sensors and generators
… H₂O₂ in particular, to answer these important redox biology questions. We began by developing a deeper understanding of how to use these protein-based peroxide sensors in a quantitative manner. We created a technique quantifying intracellular peroxide levels by converting the fluorescence …
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Disruption of mitochondrial redox homeostasis as a cellular signal.
… Mitochondria are emerging as an important redox signalling node and are involved in a myriad of signalling pathways, which have a redox component, either through a response to a particular ROS or the shift of the redox state of a responsive group. It is not surprising that mitochondria are …
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Electrogenetic pathways in cyanobacteria
… the subsequent emergence of aerobic life forms. Redox-active molecules form the basis for these bioenergetic processes inside living cells, which, entwined with their environment, must constantly modulate intracellular electron fluxes in response to metabolic needs and external conditions through …