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Showing 1 to 20 of 297 for “"Red blood cells"”.
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Depletant induced attractions in red blood cells
Red blood cells suspended in plasma are able to aggregate into linearly stacked rouleau. The aggregations can form complex clusters and branching networks which cause complications in various pathological cases. The self assembly and biophysics behind the aggregation of red blood cells into rouleau …
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Engineered red blood cells and their applications
The humble red blood cell (RBC) is the most abundant cell in the human body. Every second, a normal adult generates some 2.5 million RBCs, which subsequently circulate through the blood vessels for a lifespan of 50 or 120 days in mouse and human, respectively. RBCs are also unique in that they are …
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Numerical Simulation of Red Blood Cells in Capillaries
… to simulate the skeleton structure of the red blood cell (RBC) membrane and to study the RBC rheology with an immersed boundary method. We combine the above methodology with a distributed Lagrange multiplier/fictitious domain method to simulate the motion of a compound vesicle in a …
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Deformability of Plasmodium falciparum parasitized red blood cells
The biophysical properties of the human red blood cell (RBC) permit large deformations required for passage through narrow capillaries and spleen sinusoids. Several pathologic conditions alter RBC deformability that can result in abnormal circulation behavior. In the present work, altered RBC …
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EFFECTS OF RED BLOOD CELLS ON NITRIC OXIDE BIOACTIVITY
Red blood cells (RBCs) as one of important cells in human blood vessel are abundant in hemoglobin (Hb). Hb has four heme ferrous sites for binding oxygen, nitric oxide (NO), carbon monoxide (CO) and other small molecules. NO as an endothelial derived relaxing factor is involved in many …
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Characterization of apoptotic cell death in bovine red blood cells
Red blood cells (RBCs) in mammalian species display phenotypic variations in cellular functions and metabolism ascribed to their compositional and morphological differences. After accruing stress-induced damages, organelle-free human RBCs display a specialized apoptotic cell death process …
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Dynamic behavior of healthy and malaria infected human red blood cells
Hereditary hematological disorders and foreign organisms often introduce changes to the spectrin molecular network and membrane of human red blood cells (RBCs). These structural changes lead to altered cell shape, deformability, cytoadherence and rheology which may in turn, promote the onset of …
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Forces on a wall-bound leukocyte due to flowing red blood cells
As part of the inflammation response, white blood cells (leukocytes) bind nearly statically to blood vessel walls before they transmigrate through the endothelium and exit the vessel. The inter-cellular interactions between the wall-adhered leukocyte and flowing red blood cells (erythrocytes) play …
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Modeling and Simulation of Shape Changes of Red Blood Cells in Shear Flow
… description of the biomechanical character of red blood cells is given, along with an introduction to current computational schemes which use deformable capsules to simulate red blood cell shape change. A comprehensive two- and three-dimensional framework for the fluid-structure interaction …
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Genomics-Based Analysis of Antibody Response to Sheep Red Blood Cells in Chickens
… an important mechanism to fight pathogens and to reduce the incidence of diseases. Defining the molecular basis of antibody response may facilitate genetic improvement in the immune response of animals to pathogens. For almost 4 decades, antibody titers in response to challenge by sheep red blood …
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Variability of Cholesterol Accessibility in Human Red Blood Cells Measured Using a Bacterial Cholesterol Binding Toxin
… partitions into accessible and sequestered pools in cell membranes. Here, we describe a new assay using fluorescently-tagged anthrolysin O, a cholesterol-binding bacterial toxin, to measure accessible cholesterol in human red blood cells (RBCs). Accessible cholesterol levels were stable …
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Bedside Washing of Stored Red Blood Cells: A Simple Apparatus Based on Microscale Sedimentation in Normal Gravity
… a short period without any alteration to current blood collection and storage practices. Washing pRBC units prior to transfusion is recommended for hypersensitive patients who have a higher susceptibility towards Allergic Transfusion Reactions (ATR) due to residual plasma proteins. Unfortunately, …
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Interactions between integral membrane proteins and the cytoskeleton in red blood cells studied by measured molecular lateral diffusion
… system. The model system chosen was the red blood cell membrane because it contains several well characterized integral membrane proteins plus a peripheral cytoskeletal network. The major integral proteins are band 3 and several different types of glycophorin. The major cytoskeletal …
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Applying a microfluidic 'deformability cytometry' to measure stiffness of malaria-infected red blood cells at body and febrile temperatures
Red blood cells (RBCs) undergo repeated deformation as they traverse blood vessel, capillaries and splenic cords; RBC deformability is therefore crucial in maintaining normal blood circulation. During falciparum malaria, parasite proteins interact with the spectrin network of host RBCs, moderately …
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Amiloride-sensitive components of sodium transport in guinea pig red blood cells: A cause of imbalance of sodium ion at low temperature
… has previously been found that gaining of Na in red cells of guinea pig is faster than in those of ground squirrel during cold storage at 5$\sp\circ$C in vitro and amiloride can partially inhibit the accumulation. Also, amiloride-sensitive Na influx in guinea pig red cells is known to be larger …
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The Rational Design and Use of Novel Small-Molecule Ice Recrystallization Inhibitors for the Cryopreservation of Hematopoietic Stem Cells and Red Blood Cells
… requiring transfusion and transplantation of cells has resulted in a need to preserve these cellular therapy products. Cryopreservation is the only currently used method for the long-term storage of cells. The most commonly used cryoprotectants are 10% dimethyl sulfoxide (DMSO) for …
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Forward programming of human pluripotent stem cells to a megakaryocyte-erythrocyte bi-potent progenitor population: an in vitro system for the production of platelets and red blood cells for transfusion medicine.
… Our lab uses human induced pluripotent stem cells (iPSCs), as an attractive alternative supply, as iPSCs can be cultured indefinitely and differentiate into almost any cell type. Using a technique called forward programming, we over express three key haematological transcription factors …
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Red blood cell pathophysiology : comparative and diagnostic aspects
… the haemolytic anaemia. Since black rhinoceros red blood cells were shown to be susceptible to oxidative stress, the first stage of the work focused on the characterisation of the hexose monophosphate shunt in these cells. Results were compared to human red blood cells. To determine how these …
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