Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Recovery of Function"”.
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EFFECTS OF HYPERTONIC SALINE ON RECOVERY OF FUNCTION FOLLOWING CONTROLLED CORTICAL IMPACT BRAIN INJURY
… that nicotinamide (NAM) is beneficial for recovery of function following TBI. The first study compared the behavioral and cognitive consequences of HS and NAM as competitive therapeutic agents for the treatment of TBI. Following controlled cortical impact (CCI), bolus administrations of NAM …
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Transplantation of the Mammalian Pineal Gland: Studies of Survival, Revascularization, Reinnervation and Recovery of Function
… survival, revascularization, reinnervation, and recovery of function of transplanted newborn rat pineal glands were studied following grafting into four different locations in pinealectomized rats. These locations were the third cerebral ventricle, in situ (where the pineal gland is normally …
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Axotomy and Regeneration of the Rat Facial Nerve: A Histomorphometric Study of the Facial Nucleus, Nerve and Orbicularis Oculi Muscle in an Experimental Model of Facial Paralysis
<p>One of the most unsettling sequela of facial paralysis (FP) is the loss of eye sphincter function and the blink response, leading to functional, psychological and aesthetic deficits. A medley of restorative microsurgery approaches have been employed in treating these deficits, however full …
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A COMBINATION THERAPY OF NICOTINAMIDE AND PROGESTERONE FOR FUNCTIONAL RECOVERY FOLLOWING TRAUMATIC BRAIN INJURY
Traumatic Brain Injury (TBI) is a leading cause of death and disability in the United States for which there are no federally approved pharmacological treatments. Preclinical trials with nicotinamide (NAM) and progesterone (Prog) treatment demonstrate beneficial neuroprotection and recovery of …
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Dysfunctional but viable myocardium - ischemic heart disease assessed by magnetic resonance imaging and single photon emission computed tomography
The assessment of ischemic heart disease (IHD) often focuses on the detection of dysfunctional but viable myocardium which may improve in function following revascularization. Dysfunctional but viable myocardium is identified by distinct characteristics with regards to function, perfusion and …
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A Keratin Biomaterial for Treatment Following Spinal Cord Hemisection Injury and Investigation of Secondary Damage Mechanisms
… The only current treatment options include use of steroids, spinal fixation surgery, and rehabilitation, none of which provide any significant recovery of function. SCIs are particularly difficult to treat because of the inhibitory nature of the lesion site and overcoming it to allow for repair …
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The Role of Glutamate Transporters in Early Postnatal Hippocampal Neurogenesis
… well-characterized in the subgranular zone (SGZ) of the hippocampal dentate gyrus however, early postnatal development of the dentate gyrus and changes in the neurogenic niche during this time have not been well-studied. Using a well-characterized transgenic mouse that labels early neural …
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A Comparison of Post-Injury Symptomatology and Recovery Following Concussion Versus Orthopedic Injury
… influence post-concussion symptom reporting and recovery. The first aim of this dissertation (Study 1) was to conduct a review of the literature on post-injury symptoms and outcomes following concussion versus OI in children and adolescents, focusing on study design and synthesizing conclusions …
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Cognitive Functioning of Male Adult Children of Alcoholics and Control Subjects While Under the Influence of Acute Alcohol Intoxication
… research has suggested that adult children of alcoholics (ACAs) are at increased risk for the development of alcoholism. Differences between ACA and control subjects have been reported for a range of cognitive, affective and behavioral measures in addition to certain components of the …
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Functional role of NMDA receptor subunit composition in metaplasticity
Modification of synapses by neural activity has been proposed to be the substrate for experience-dependent brain development, learning, and recovery of function after brain damage. In the visual cortex, the strength of cortical synapses can be bidiredionally modified, where in response to a …
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AMPA-receptor mediated plasticity within the rat spinal cord
… has demonstrated that the spinal cord is capable of a simple form of instrumental learning. In this instrumental learning paradigm, rats typically receive a complete spinal transection at the second thoracic vertebra, and are tested 24 hours after surgery. Subjects that receive shock to a hind leg …
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Movement velocity effect on cortical reorganization and finger function in stroke.
Paralysis of limb movement after stroke is a major cause of disability. Recovery of function is linked to favorable brain reorganization. The brain is primed for neuroplastic reorganization after stroke but the rehabilitation interventions must be well designed. Forced use of the paretic limb as a …
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Occupational Therapy Treatments and Upper Extremity Motor and Self-Care Outcomes of Patients Post-CVA
… U.S. citizens live with the disabling effects of strokes, which can limit function in one or more of the following areas: mobility, basic activities of daily living, bowel or bladder control, cognition, emotional functioning, among other disabling conditions (Gresham et al., 1995). Occupational …
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Novel Use of Dual Anti-Inflammatory Therapy to Overcome Drug Resistance and Improve Functional Recovery Following Spinal Cord Injury
… no proven effective treatments that can improve recovery of function in SCI patients. Many therapeutic compounds have shown promise in preclinical models of SCI, but all of these have fallen short in clinical trials.</p> <p>P-glycoprotein (Pgp) is an active transporter expressed on capillary …
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Pharmacological activation of pro-survival pathways as a strategy for improving donor heart preservation
Despite the development and use of specialised cardiac preservation solutions, the quality of the donor heart may still be compromised by its obligatory exposure to periods of ischaemia (both cold and warm) followed by reperfusion upon reintroduction of the recipient circulation. This is reflected …
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Wearable robotics for rehabilitation
Robots have become an integral part of modern industrial manufacturing. In healthcare, the impact of robotic devices has not yet been established but there has been considerable discussion on their use as assistive devices and as products or systems that aid in rehabilitation of disabled people. I …
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Recovery of Ambulation in Medically Managed Thoracolumbar Disc Extrusions in Non-Ambulatory Small Dogs
… present to referral practices the consequences of which range along a spectrum from spinal hyperaesthesia without concurrent neurological deficits to paraplegia with absent pelvic limb and tail deep nociception, something usually termed “deep pain negative”. Although we have been aware of this …
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Predictors of Persistent Neurobehavioral Symptoms in Adolescents with Mild Traumatic Brain Injury Using a Novel Clinical Tool
… and poorly understood. A small percentage of adolescents (roughly 20%) will experience persistent symptoms following mTBI that can be disruptive in many areas of daily functioning. Including measures in assessment that are specific to adolescents but capture symptoms beyond injury may lead …
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Investigating molecular mechanisms of neuronal regeneration: a microarray approach.
… response that generally leads to some recovery of function. In contrast, the response to injury in the adult mammalian central nervous system (CNS) is abortive and adult CNS neurons do not normally regenerate. We used a microarray approach to identify putative regeneration-associated …
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Assessment and improvement of access and quality in lower gastrointestinal endoscopy
… an increasing demand for LGE. The overall aims of this thesis were to identify methods of improving both the availability and the technical quality of LGE in the National Health Service, United Kingdom.This thesis attempts to bring some of these concepts together in a series of studies as listed …
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