Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Recombinant Vaccine"”.
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Approaches towards vaccine development against Neospora caninum
… A commercially available, inactivated vaccine induces the undesirable Th2 type of immunity against N. caninum. Therefore, two approaches towards vaccine development against N. caninum that were designed to induce potent cell mediated immunity have been explored in this dissertation. The …
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Development of plant-produced Bluetongue virus vaccines
… rates of livestock were reported. The only vaccines currently approved and commercially available for use are live-attenuated or inactivated virus strains and although these are effective, there is the risk of reversion in the case of live-attenuated strains to more virulent forms by …
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Phylogenetics and New Approaches to Vaccine Development for West Nile
… indicating a virus with a competitive edge. Recombinant vesicular stomatitis virus (rVSV) based vaccines cleverly incorporate reverse genetics to recover a recombinant virus expressing a foreign antigen of interest. rVSV vectored vaccines expressing the LSU-AR01 envelope (E) glycoprotein were …
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Characterization of Avirulent Turkey Hemorrhagic Enteritis Virus: A Study of the Molecular Basis for Variation in Virulence and the Occurrence of Persistent Infection
… lesions and mortality are used in live-virus vaccines that protect turkeys from virulent field challenge. The cause for the difference in phenotype between virulent and avirulent strains is unknown. The full-length genome of the Virginia Avirulent Strain (VAS) of THEV was sequenced and …
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Immunologic and Protective Effects of Vaccines for Mycobacterium marinum in Morone sp
Recombinant and DNA vaccines utilizing Mycobacterium sp. antigen 85A (Ag85A) were assessed for immunostimulatory and protective effects against M. marinum. Because of their known susceptibility to piscine mycobacteriosis, Morone sp. were utilized as the models for these studies. The first study …
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Baculovirus surface display of influenza virus haemagglutinin and its potential as a vaccine
… regime. To date, the vast majority of influenza vaccines are manufactured using conventional technology based on embryonated hen’s eggs that takes several months to produce. However, the threat of influenza virus outbreaks emphasizes the need for a novel, rapid vaccine technology that can respond …
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Strategy for speedy field diagnosis and control of avian influenza viruses (AIV) outbreak at the point of contact/care (POC)
… from viral detection to the release of the vaccine for that particular strain. A rapid and cost effective diagnostic method for the early detection of AI viruses, as well as a more effective vaccine that can be produced quickly, are urgently needed as tools for AI outbreak management. …
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Development and Characterization of a Modified Vaccinia Ankara Vaccine Candidate Expressing the SARS-CoV-2 Spike Glycoprotein
… of the virus to escape host immunity, new vaccines and refinement of first-generation vaccines to improve protection against SARS-CoV-2 variants of concern is vital. In Africa, the cost of vaccine manufacturing as well as the scarcity in resources for storage and distribution have all …
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Prophylaxis of disease caused by bacterial pathogens of man
… investigated and methods for the expression of recombinant proteins in E. coli have been devised This information has been used to develop improved PCR-based diagnostic tests, and to investigate structure-function relationships. A high resolution crystal structure of a-toxin (phospholipase C) is …
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Development of Virus-like particles (VLPs) Based Vaccines Against Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Porcine Epidemic Diarrhea Virus (PEDV)
… heterogeneity over the years, making a vaccine solution ever so challenging. Modified live-attenuated vaccines (MLVs) have been the most common approach, but the long-term safety regarding their potential for pathogenic reversion still needs to be addressed. Subunit based vaccines have …